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Protocol
Hong Zhang
Chengdu University of Traditional Chinese Medicine
Corresponding Author
ORCiD: https://orcid.org/0000-0002-6417-8399
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Background: Posttraumatic stress disorder (PTSD) is a debilitating mental disorder that occurs after exposure to traumatic events. This disorder can result in a interference to personal and family functioning, causing great threat to people's life and public health. Animal models remain the effective tools to the pathophysiological study of PTSD, There are many model paradigms of PTSD, and the purpose of this study is to evaluate the effect of different model paradigms of PTSD on depression-like and fear-like behavior using systematic review and network meta-analysis (NMA).
Methods: The authors will retrieve a total of seven electronic databases by April 2020. After a series of screening, the two researchers will use Aggregate Data Drug Information System (ADDIS) and Stata software to analyze the data extracted from randomized controlled animal studies in PTSD rats . Ultimately, the evidence grade of the results will be evaluated.
Discussion: The results of this study will provide references for evaluating the influence of different rats models of PTSD on depression-like and fear-like behavior, and provide decision-making references for clinical practice.
Systematic review registration: PROSPERO CRD42020182389.
Keywords
network meta analysis, protocol, animal model, PTSD, behavior
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Peer Review Timeline
CURRENT STATUS: Under Revision
Version 1
Posted 14 Jul, 2020
No community comments so far
Editorial decision: Revise before peer review
On 01 Dec, 2021
Reviewers invited
Invitations sent on 07 Feb, 2021
Editor assigned
On 10 Sep, 2020
Editor invited
On 09 Sep, 2020
Submission checks complete
On 10 Jul, 2020
First submitted
On 09 Jul, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Psychology
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A new preprint design is coming!
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This preprint is under consideration at Systematic Reviews. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Protocol
Hong Zhang
Chengdu University of Traditional Chinese Medicine
Corresponding Author
ORCiD: https://orcid.org/0000-0002-6417-8399
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Revision
Version 1
Posted 14 Jul, 2020
No community comments so far
Editorial decision: Revise before peer review
On 01 Dec, 2021
Reviewers invited
Invitations sent on 07 Feb, 2021
Editor assigned
On 10 Sep, 2020
Editor invited
On 09 Sep, 2020
Submission checks complete
On 10 Jul, 2020
First submitted
On 09 Jul, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Psychology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Posttraumatic stress disorder (PTSD) is a debilitating mental disorder that occurs after exposure to traumatic events. This disorder can result in a interference to personal and family functioning, causing great threat to people's life and public health. Animal models remain the effective tools to the pathophysiological study of PTSD, There are many model paradigms of PTSD, and the purpose of this study is to evaluate the effect of different model paradigms of PTSD on depression-like and fear-like behavior using systematic review and network meta-analysis (NMA).
Methods: The authors will retrieve a total of seven electronic databases by April 2020. After a series of screening, the two researchers will use Aggregate Data Drug Information System (ADDIS) and Stata software to analyze the data extracted from randomized controlled animal studies in PTSD rats . Ultimately, the evidence grade of the results will be evaluated.
Discussion: The results of this study will provide references for evaluating the influence of different rats models of PTSD on depression-like and fear-like behavior, and provide decision-making references for clinical practice.
Systematic review registration: PROSPERO CRD42020182389.
This is a list of supplementary files associated with this preprint. Click to download.
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