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In the present study, we have in situ synthesized polypyrrole (PPy) on the hydroxyethyl cellulose/soy protein isolate (HEC/SPI) sponges to construct electro-conductive HEC/SPI/PPy composite sponges (EHSS-Pn, n༞0). The composite sponges were characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), conductivity and mechanical tests. The results indicated that EHSS-Pn still exhibit homogenous inter-connected macroporous structure for cell adhesion, proliferation and metabolism, indicating that the incorporation of PPy didn’t break the original HEC/SPI sponge structure. The electrical conductivity and mechanical properties of the HEC/SPI sponge were improved significantly by the incorporation of PPy. Cytocompatibility and hemocompatibility of all the sponges were evaluated by a series of in vitro experiments. The results of MTT assay and cell direct contact tests showed that the introduction of PPy didn’t cause any cytotoxicity and EHSS-Pn had good biocompatibility. Moreover, EHSS-Pn had good hemocompatibility and no significant side effects on the anticoagulant whole blood with the introduction of PPy. Therefore, the electro-conductive EHSS-Pn showed potential application in the tissue engineering field that requires electrical conductivity for stimulation or sensing such as neural tissue restoration.
Keywords
hydroxyethyl cellulose, soy protein isolate, sponges, polypyrrole, electro-conductive, biocompatibility
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View the published article at Cellulose.
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Posted 03 May, 2021
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See the published version of this preprint at Cellulose.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at Cellulose.
Version 1
Posted 03 May, 2021
No community comments so far
Reviewers invited
Invitations sent on 29 Apr, 2021
Reviews received
Received 28 Apr, 2021
Editor invited
On 27 Apr, 2021
Editor assigned
On 25 Apr, 2021
First submitted
On 10 Apr, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Materials Chemistry
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at Cellulose.
In the present study, we have in situ synthesized polypyrrole (PPy) on the hydroxyethyl cellulose/soy protein isolate (HEC/SPI) sponges to construct electro-conductive HEC/SPI/PPy composite sponges (EHSS-Pn, n༞0). The composite sponges were characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), conductivity and mechanical tests. The results indicated that EHSS-Pn still exhibit homogenous inter-connected macroporous structure for cell adhesion, proliferation and metabolism, indicating that the incorporation of PPy didn’t break the original HEC/SPI sponge structure. The electrical conductivity and mechanical properties of the HEC/SPI sponge were improved significantly by the incorporation of PPy. Cytocompatibility and hemocompatibility of all the sponges were evaluated by a series of in vitro experiments. The results of MTT assay and cell direct contact tests showed that the introduction of PPy didn’t cause any cytotoxicity and EHSS-Pn had good biocompatibility. Moreover, EHSS-Pn had good hemocompatibility and no significant side effects on the anticoagulant whole blood with the introduction of PPy. Therefore, the electro-conductive EHSS-Pn showed potential application in the tissue engineering field that requires electrical conductivity for stimulation or sensing such as neural tissue restoration.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
Figure 9
This is a list of supplementary files associated with this preprint. Click to download.
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