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Research article
Guohao Xie
the First Affiliated Hospital, School of Medicine, Zhejiang University
Corresponding Author
ORCiD: https://orcid.org/0000-0001-9793-021X
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Confocal laser endomicroscopy (CLE) has advantages in detecting gastric neoplastic lesions, meanwhile it requires strict patient cooperation. Sedation could improve patient cooperation and quality of endoscopy. However, sedation is still not very popular in some resource-limited countries and regions. The purpose of this study was to compare propofol-based sedated versus un-sedated CLE in the value of diagnosing early gastric cancer (EGC) and precancerous lesions.
Methods: A retrospective, cohort, single center study of 226 patients who underwent CLE between January 1, 2015 and December 31, 2017 was performed. Patients enrolled were allocated into the propofol-based sedated group (n=126) and the un-sedated group (n=100). The comparison of validity and reliability of CLE for identifying EGC and precancerous lesions between the two groups was performed through analyzing CLE diagnosis and pathological diagnosis. Reporting followed the STROBE guidelines.
Results: The area under receiver operating characteristic curve (AUROC) of diagnosing EGC in the sedated group was 0.97 (95% CI: 0.95 to 0.99), which was higher than that in the un-sedated group (0.88 (95% CI: 0.80 to 0.97), P =0.0407). CLE with sedation performed better than without sedation in diagnosing intraepithelial neoplasia and intestinal metaplasia (P =0.0008 and P =0.0001, respectively).
Conclusion: Propofol based sedation was associated with improved diagnostic value of CLE for detecting EGC as well as precancerous lesions (intraepithelial neoplasia OR intestinal metaplasia).
Keywords
propofol-based sedation, confocal laser endomicroscopy, early gastric cancer, precancerous lesions
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CURRENT STATUS: Published
View the published article at BMC Anesthesiology.
Version 3
Posted 31 Dec, 2020
No community comments so far
Editorial decision: Minor revision
On 03 Jan, 2021
Editor assigned
On 15 Dec, 2020
Submission checks complete
On 15 Dec, 2020
Editor invited
On 15 Dec, 2020
No comments provided
Editorial decision: Minor revision
On 28 Nov, 2020
Editor assigned
On 17 Nov, 2020
Submission checks complete
On 17 Nov, 2020
Editor invited
On 17 Nov, 2020
No comments provided
Reviewer #2 agreed
On 20 Sep, 2020
Review #2 received
Received 20 Sep, 2020
Editorial decision: Major revision
On 20 Sep, 2020
Review #1 received
Received 13 Aug, 2020
Reviewer #1 agreed
On 24 Jul, 2020
Reviewers invited
Invitations sent on 19 Jul, 2020
Editor assigned
On 16 Jul, 2020
Submission checks complete
On 12 Jul, 2020
Editor invited
On 10 Jul, 2020
First submitted
On 08 Jul, 2020
Metrics
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Subject Areas
Anesthesiology & Pain Medicine
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A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
See the published version of this preprint at BMC Anesthesiology.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Guohao Xie
the First Affiliated Hospital, School of Medicine, Zhejiang University
Corresponding Author
ORCiD: https://orcid.org/0000-0001-9793-021X
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Anesthesiology.
Version 3
Posted 31 Dec, 2020
No community comments so far
Editorial decision: Minor revision
On 03 Jan, 2021
Editor assigned
On 15 Dec, 2020
Submission checks complete
On 15 Dec, 2020
Editor invited
On 15 Dec, 2020
No comments provided
Editorial decision: Minor revision
On 28 Nov, 2020
Editor assigned
On 17 Nov, 2020
Submission checks complete
On 17 Nov, 2020
Editor invited
On 17 Nov, 2020
No comments provided
Reviewer #2 agreed
On 20 Sep, 2020
Review #2 received
Received 20 Sep, 2020
Editorial decision: Major revision
On 20 Sep, 2020
Review #1 received
Received 13 Aug, 2020
Reviewer #1 agreed
On 24 Jul, 2020
Reviewers invited
Invitations sent on 19 Jul, 2020
Editor assigned
On 16 Jul, 2020
Submission checks complete
On 12 Jul, 2020
Editor invited
On 10 Jul, 2020
First submitted
On 08 Jul, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Anesthesiology & Pain Medicine
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Anesthesiology.
Background: Confocal laser endomicroscopy (CLE) has advantages in detecting gastric neoplastic lesions, meanwhile it requires strict patient cooperation. Sedation could improve patient cooperation and quality of endoscopy. However, sedation is still not very popular in some resource-limited countries and regions. The purpose of this study was to compare propofol-based sedated versus un-sedated CLE in the value of diagnosing early gastric cancer (EGC) and precancerous lesions.
Methods: A retrospective, cohort, single center study of 226 patients who underwent CLE between January 1, 2015 and December 31, 2017 was performed. Patients enrolled were allocated into the propofol-based sedated group (n=126) and the un-sedated group (n=100). The comparison of validity and reliability of CLE for identifying EGC and precancerous lesions between the two groups was performed through analyzing CLE diagnosis and pathological diagnosis. Reporting followed the STROBE guidelines.
Results: The area under receiver operating characteristic curve (AUROC) of diagnosing EGC in the sedated group was 0.97 (95% CI: 0.95 to 0.99), which was higher than that in the un-sedated group (0.88 (95% CI: 0.80 to 0.97), P =0.0407). CLE with sedation performed better than without sedation in diagnosing intraepithelial neoplasia and intestinal metaplasia (P =0.0008 and P =0.0001, respectively).
Conclusion: Propofol based sedation was associated with improved diagnostic value of CLE for detecting EGC as well as precancerous lesions (intraepithelial neoplasia OR intestinal metaplasia).
Figure 1
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