This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
Research
honggang liu
department of pathology, key laboratory of head and neck molecular diagnosis pathology,beijing tongren hospital ,capital medical university
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: This study aimed to investigate the expression levels of chemokine-like factor-like MARVEL transmembrane domain-containing family member 6 (CMTM6) and PD-L1 in cervical squamous cell carcinoma and their clinical significance.
Methods: We used immunohistochemistry to detect the expression of CMTM6 and PD-L1 in 41 cases of normal cervical squamous mucosa tissue and 76 cervical squamous cell carcinomas. Chi-square test was used to analyze the difference of CMTM6 between cervical squamous carcinoma and normal squamous mucosa.
Results: The results showed that the expression of CMTM6 and PD-L1 in cervical squamous carcinoma was significantly higher than that in normal squamous mucosa (p<0.05). There is a positive correlation between the expression of CMTM6 and PD-L1 in cervical squamous carcinoma (p<0.05). There is no correlation between CMTM6 and HPV infection in cervical squamous carcinoma. In addition, CMTM6 expression is positively correlated with lymph node metastasis and nerve invasion for cervical squamous carcinoma (p<0.05). PD-L1 expression is positively correlated with the differentiation of cervical squamous carcinoma.
Conclusions: The expression of CMTM6 and PD-L1 is closely correlated in cervical squamous carcinoma , and may be used as a molecular target for cervical cancer in the future.
Keywords
CMTM6, PD-L1, cervical squamous cell carcinoma, metastasis, prognosis
Figure 1
Loading...
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 16 Apr, 2021
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Pathology
Learn more about our company.
A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research
honggang liu
department of pathology, key laboratory of head and neck molecular diagnosis pathology,beijing tongren hospital ,capital medical university
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 16 Apr, 2021
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Pathology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: This study aimed to investigate the expression levels of chemokine-like factor-like MARVEL transmembrane domain-containing family member 6 (CMTM6) and PD-L1 in cervical squamous cell carcinoma and their clinical significance.
Methods: We used immunohistochemistry to detect the expression of CMTM6 and PD-L1 in 41 cases of normal cervical squamous mucosa tissue and 76 cervical squamous cell carcinomas. Chi-square test was used to analyze the difference of CMTM6 between cervical squamous carcinoma and normal squamous mucosa.
Results: The results showed that the expression of CMTM6 and PD-L1 in cervical squamous carcinoma was significantly higher than that in normal squamous mucosa (p<0.05). There is a positive correlation between the expression of CMTM6 and PD-L1 in cervical squamous carcinoma (p<0.05). There is no correlation between CMTM6 and HPV infection in cervical squamous carcinoma. In addition, CMTM6 expression is positively correlated with lymph node metastasis and nerve invasion for cervical squamous carcinoma (p<0.05). PD-L1 expression is positively correlated with the differentiation of cervical squamous carcinoma.
Conclusions: The expression of CMTM6 and PD-L1 is closely correlated in cervical squamous carcinoma , and may be used as a molecular target for cervical cancer in the future.
Figure 1
Loading...