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Research Article
Fernanda Vianna
Universidade Federal do Rio Grande do Sul
Corresponding Author
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Erythema Nodosum Leprosum (ENL) is an acute and systemic inflammatory reaction of leprosy characterized by painful nodules and involvement of various organs. Thalidomide is an immunomodulatory and anti-inflammatory drug currently used to treat conditions such as ENL and multiple myeloma (MM). Cereblon protein was described as the primary target of thalidomide teratogenicity. Moreover, it was postulated that CRBN is necessary for the efficacy of thalidomide and its analogs in the treatment of MM. In this study, we evaluate the influence of CRBN genetic variants on the dose of thalidomide used in the treatment of ENL and on the manifestation of adverse effects during treatment for ENL. Polymorphisms rs1620675, rs1672770 and rs4183 located in regions flanking the part of the gene encoding the portion of the protein that binds to thalidomide were evaluated. An association with adverse ocular and gastrointestinal effects was observed. These results show that CRBN polymorphisms could alter the expression or activity of the protein and influence the development of adverse effects in response to thalidomide in ENL.
Keywords
Cereblon, thalidomide, erythema nodosum leprosum, pharmacogenomics
No competing interests reported.
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A new preprint design is coming!
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research Article
Fernanda Vianna
Universidade Federal do Rio Grande do Sul
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 29 Apr, 2021
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Erythema Nodosum Leprosum (ENL) is an acute and systemic inflammatory reaction of leprosy characterized by painful nodules and involvement of various organs. Thalidomide is an immunomodulatory and anti-inflammatory drug currently used to treat conditions such as ENL and multiple myeloma (MM). Cereblon protein was described as the primary target of thalidomide teratogenicity. Moreover, it was postulated that CRBN is necessary for the efficacy of thalidomide and its analogs in the treatment of MM. In this study, we evaluate the influence of CRBN genetic variants on the dose of thalidomide used in the treatment of ENL and on the manifestation of adverse effects during treatment for ENL. Polymorphisms rs1620675, rs1672770 and rs4183 located in regions flanking the part of the gene encoding the portion of the protein that binds to thalidomide were evaluated. An association with adverse ocular and gastrointestinal effects was observed. These results show that CRBN polymorphisms could alter the expression or activity of the protein and influence the development of adverse effects in response to thalidomide in ENL.
No competing interests reported.
This is a list of supplementary files associated with this preprint. Click to download.
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