Araki A, Nara H, Rahman M, Onoda T, Li J, Juliana FM, et al. (2013) Role of interleukin-21 isoform in dextran sulfate sodium (DSS)- induced colitis, Cytokine 62:262–271. DOI: 10.1016/j.cyto.2013.03.006
Ariotti S, Hogenbirk MA, Dijkgraaf FE, Visser LL, Hoekstra ME, Song JY, et al. (2014) T cell memory: skin-resident memory CD8+ T cells trigger a state of tissue-wide pathogen alert. Science 346:101–105. DOI: 10.1126/science.1254803
Barker BR, Gladstone MN, Gillard GO, Panas MW, Letvin NL. (2010) Critical role for IL-21 in both primary and memory anti-viral CD8+ T-cell responses. Eur J Immunol 40:3085–3096. DOI: 10.1002/eji.200939939
Cui W, Liu Y, Weinstein JS, Craft J, Kaech SM. (2011) An interleukin- 21-interleukin-10-STAT3 pathway is critical for functional maturation of memory CD8+ T cells. Immunity 35:792–805. DOI: 10.1016/j.immuni.2011.09.017
Elsaesser H, Sauer K, Brooks DG. (2009) IL-21 is required to control chronic viral infection. Science 324:1569–1572. DOI: 10.1126/science.1174182
Fröhlich A, Kisielow J, Schmitz I, Freigang S, Shamshiev AT, Weber J, et al. (2009) IL-21R on T cells is critical for sustained functionality and control of chronic viral infection. Science 324:1576–1580. DOI: 10.1126/science.1172815
Gebhardt T, Wakim LM, Eidsmo L, Reading PC, Heath WR, Carbone FR. (2009) Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus. Nat Immunol 10:524–530. DOI: 10.1038/ni.1718
Hansen SG, Ford JC, Lewis MS, Ventura AB, Hughes CM, CoyneJohnson L, et al. (2011) Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine. Nature 473:523–527. DOI: 10.1038/nature10003
Hansen SG, Piatak MJr, Ventura AB, Hughes CM, Gilbride RM, Ford JC, et al. (2013) Immune clearance of highly pathogenic SIV infection. Nature 502:100–104. DOI: 10.1038/nature22984
Hansen SG, Vieville C, Whizin N, Coyne-Johnson L, Siess DC, Drummond DD, et al. (2009) Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge. Nat Med 15:293–299. DOI: 10.1038/nm.1935
Hinrichs CS, Spolski R, Paulos CM, Gattinoni L, Kerstann KW, Palmer DC, et al. (2008) IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy. Blood 111:5326–5333. DOI: 10.1182/blood-2007-09-113050
Iijima N, Iwasaki A. (2014) T cell memory: a local macrophage chemokine network sustains protective tissue-resident memory CD4 T cells. Science 346:93–98. DOI: 10.1126/science.1257530
Kaech SM, Cui W. (2012) Transcriptional control of effector and memory CD8+ T cell differentiation. Nat Rev Immunol 12:749–761. DOI: 10.1038/nri3307
Masopust D, Vezys V, Marzo AL, Lefrancois L. (2001) Preferential localization of effector memory cells in nonlymphoid tissue. Science 291:2413–2417. DOI: 10.1126/science.1058867
Moretto MM, Khan IA. (2016) IL-21 is important for induction of KLRG1+ effector CD8 T cells during acute intracellular infection. J Immunol 196:375–384. DOI: 10.4049/jimmunol.1501258
Mueller SN, Gebhardt T, Carbone FR, Heath WR. (2013) Memory T cell subsets, migration patterns, and tissue residence. Annu Rev Immunol 31:137–161. DOI: 10.1146/annurev-immunol-032712-095954
Nara H, Rahman M, Araki A, Jin L, Takeda Y, Asao H. (2013) IL-21 isoform is a membrane-bound ligand and activates directly interacted cells. Cytokine 61:656-663. DOI: 10.1016/j.cyto.2012.12.010
Novy P, Huang X, Leonard WJ, Yang Y. (2011) Intrinsic IL-21 signaling is critical for CD8 T cell survival and memory formation in response to vaccinia viral infection. J Immunol 186:2729–2738. DOI: 10.4049/jimmunol.1003009
Parrish-Novak J, Dillon SR, Nelson A, Hammond A, Sprecher C, Gross JA, et al. (2000) Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature 408:57–63. DOI: 10.1038/35040504
Rahman M, Nara H, Onoda T, Araki A, Li J, Hoshino T, et al. (2007) Cloning and characterization of an isoform of interleukin-21. FEBS Lett 581:4001–4009. DOI: 10.1016/j.febslet.2007.07.034
Reyes-Sandoval A, Wyllie DH, Bauza K, Milicic A, Forbes EK, Rollier CS, et al. (2011) CD8+ T effector memory cells protect against liver-stage malaria. J Immunol 187:1347–1357. DOI: 10.4049/jimmunol.1100302
Sallusto F, Lenig D, Fӧrster R, Lipp M, Lanzavecchia A. (1999) Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401:708–712. DOI: 10.1038/44385
Sheridan BS, Pham QM, Lee YT, Cauley LS, Puddington L, Lefrancois L. (2014) Oral infection drives a distinct population of intestinal resident memory CD8+ T cells with enhanced protective function. Immunity 40:747-757. DOI: 10.1016/j.immuni.2014.03.007
Spolski R, Leonard WJ. (2008) Interleukin-21: basic biology and implications for cancer and autoimmunity. Annu Rev Immunol 26:57–79. DOI: 10.1146/annurev.immunol.26.021607.090316
Spolski R, Leonard WJ. (2014) Interleukin-21: a double-edged sword with therapeutic potential. Nat Rev Drug Discov 13:379–395. DOI: 10.1038/nrd4296
Wherry EJ, Teichgräber V, Becker TC, Masopust D, Kaech SM, Antia R, et al. von Andrian U.H., Ahmed R. (2003) Lineage relationship and protective immunity of memory CD8 T cell subsets. Nat Immunol 4:225–234. DOI: 10.1038/ni889
Wollert T, Pasche B, Rochon M, Deppenmeier S, van den Heuvel J, Gruber AD, et al. (2007) Extending the host range of Listeria monocytogenes by rational protein design. Cell 129:891-902. DOI: 10.1016/j.cell.2007.03.049
Yi JS, Du M, Zajac AJ. (2009) A vital role for interleukin-21 in the control of a chronic viral infection. Science 324:1572–1576. DOI: 10.1126/science.1175194
Yi JS, Ingram JT, Zajac AJ. (2010) IL-21 deficiency influences CD8 T cell quality and recall responses following an acute viral infection. J Immunol 185:4835–4845. DOI: 10.4049/jimmunol.1001032
Zeng R, Spolski R, Finkelstein SR, Oh S, Kovanen PE, Hinrichs CS, et al. (2005) Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function. J Exp Med 201:139–148. DOI: 10.1084/jem.20041057