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Research article
Tamara Joy Phiri
Queen Elizabeth Central Hospital
Corresponding Author
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Aims This study aimed to establish the prevalence of gestational diabetes mellitus (GDM) among urban women in Blantyre where the prevalence was previously unknown. A comparison was made between the prevalence determined using WHO criteria and that using the recent International Association of Diabetes in Pregnancy Study Group (IADPSG) criteria. Methods 2274 consecutive women presenting to five antenatal clinic sites in Blantyre had a screening random blood glucose (RBG). Of these, a subsample of 250 women were randomly selected for an oral glucose tolerance test (OGTT). Logistic regression was used to quantify the association between various exposure variables and prevalence of diabetes. Results Mean age was 25 years (range 14 – 43 years), 66% were in the third trimester. Mean RBG was 5.1mmol/L (range 2.4 - 10.6). Overall prevalence of GDM was 1.6% and 24% using the WHO and IADPSG criteria respectively. GDM was associated with older maternal age, high parity and attendance at government antenatal clinics but not with MUAC, BMI, positive family history of diabetes or previous poor neonatal outcome. There was no correlation between random blood glucose and gestational diabetes diagnosed on the oral glucose tolerance test. Conclusions The prevalence of GDM in Blantyre using WHO criteria was low in the predominantly young population that was screened. A much higher proportion had GDM based on the IADPSG criteria and these may warrant long term follow up. GDM was not associated with some previously described risk factors for GDM suggesting a different risk factor profile compared to high income countries.
Keywords
gestational diabetes mellitus, diabetes mellitus, non-communicable diseases, pregnancy, sub-Saharan Africa, Malawi
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A new preprint design is coming!
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research article
Tamara Joy Phiri
Queen Elizabeth Central Hospital
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 23 Aug, 2019
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Maternal & Fetal Medicine
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Aims This study aimed to establish the prevalence of gestational diabetes mellitus (GDM) among urban women in Blantyre where the prevalence was previously unknown. A comparison was made between the prevalence determined using WHO criteria and that using the recent International Association of Diabetes in Pregnancy Study Group (IADPSG) criteria. Methods 2274 consecutive women presenting to five antenatal clinic sites in Blantyre had a screening random blood glucose (RBG). Of these, a subsample of 250 women were randomly selected for an oral glucose tolerance test (OGTT). Logistic regression was used to quantify the association between various exposure variables and prevalence of diabetes. Results Mean age was 25 years (range 14 – 43 years), 66% were in the third trimester. Mean RBG was 5.1mmol/L (range 2.4 - 10.6). Overall prevalence of GDM was 1.6% and 24% using the WHO and IADPSG criteria respectively. GDM was associated with older maternal age, high parity and attendance at government antenatal clinics but not with MUAC, BMI, positive family history of diabetes or previous poor neonatal outcome. There was no correlation between random blood glucose and gestational diabetes diagnosed on the oral glucose tolerance test. Conclusions The prevalence of GDM in Blantyre using WHO criteria was low in the predominantly young population that was screened. A much higher proportion had GDM based on the IADPSG criteria and these may warrant long term follow up. GDM was not associated with some previously described risk factors for GDM suggesting a different risk factor profile compared to high income countries.
Figure 1
This is a list of supplementary files associated with this preprint. Click to download.
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