This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research article
Nguyen Ngoc Anh
Hanoi Medical University
Corresponding Author
ORCiD: https://orcid.org/0000-0001-7383-0652
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
This study aims to identify normal HRAM values and related factors in healthy Vietnamese adults.
Methods
This cross-sectional study was conducted at Viet Duc hospital, Hanoi, Vietnam, during April and May, 2019. Healthy volunteers were recruited to participate in the study. Anorectal measurement values including pressure and an electromyographical signal from the digestive tract were recorded. Differences between groups were analyzed using paired t-tests, and linear regression models was used to compare anorectal values between men and women.
Results
A total of the 76 healthy volunteers was recruited. The mean functional anal canal length was 4.2 ± 0.5 cm while the mean anal high-pressure zone (HPZ) length was 3.4 ± 0.5 cm. The mean defecation index was 1.4 ± 0.8, with values ranging from 0.3 to 5.0. The mean threshold volume to elicit RAIR was 18.1 mL. Mean rectal sensation values were 32.4 mL, 81.6 mL, and 159 mL at the first sensation, the desire to defecate, and the urge to defecate, respectively. Dyssynergic patterns occurred in approximately 50% of study participants and included mainly types I (27.6%) and III (14.6%). There were significant differences between males and females in maximum anal squeeze pressure, maximum anal cough pressure, maximum anal strain pressure, maximum rectal cough pressure, and maximum rectal strain pressure (all p < 0.01).
Conclusions
This study establishes normal HRAM values in healthy Vietnamese adults, particularly with regards to normal values of anorectal pressure and rectal sensation. Further studies that include larger sample sizes should be conducted in order to further confirm the constants and their relationships.
Keywords
High-resolution anorectal manometry, Anorectal manometry, Normal Values, Healthy people, Vietnam
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research article
Nguyen Ngoc Anh
Hanoi Medical University
Corresponding Author
ORCiD: https://orcid.org/0000-0001-7383-0652
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 20 Jul, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Gastroenterology & Hepatology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
This study aims to identify normal HRAM values and related factors in healthy Vietnamese adults.
Methods
This cross-sectional study was conducted at Viet Duc hospital, Hanoi, Vietnam, during April and May, 2019. Healthy volunteers were recruited to participate in the study. Anorectal measurement values including pressure and an electromyographical signal from the digestive tract were recorded. Differences between groups were analyzed using paired t-tests, and linear regression models was used to compare anorectal values between men and women.
Results
A total of the 76 healthy volunteers was recruited. The mean functional anal canal length was 4.2 ± 0.5 cm while the mean anal high-pressure zone (HPZ) length was 3.4 ± 0.5 cm. The mean defecation index was 1.4 ± 0.8, with values ranging from 0.3 to 5.0. The mean threshold volume to elicit RAIR was 18.1 mL. Mean rectal sensation values were 32.4 mL, 81.6 mL, and 159 mL at the first sensation, the desire to defecate, and the urge to defecate, respectively. Dyssynergic patterns occurred in approximately 50% of study participants and included mainly types I (27.6%) and III (14.6%). There were significant differences between males and females in maximum anal squeeze pressure, maximum anal cough pressure, maximum anal strain pressure, maximum rectal cough pressure, and maximum rectal strain pressure (all p < 0.01).
Conclusions
This study establishes normal HRAM values in healthy Vietnamese adults, particularly with regards to normal values of anorectal pressure and rectal sensation. Further studies that include larger sample sizes should be conducted in order to further confirm the constants and their relationships.
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