This preprint is under consideration at BMC Musculoskeletal Disorders. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
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Research Article
Yang Zhang
Nanfang Hospital
Corresponding Author
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Background
To study the impact of valvular heart disease (VHD) on joint replacement, particularly the clinical impactions of aortic stenosis before total/partial hip arthroplasty.
Methods
This was a retrospective cohort study. Data on patients who had undergone joint replacement from 2005 to 2014 were extracted from the NIS database. Linear regression was used to analyze the essential characteristics of patients. Multivariate regression was used to estimate the correlation among demographics, comorbidities, complications, hospitalization costs, and time.
Results
Of the hip replacement surgeries, VHDs accounted for 5.56% and aortic stenosis (AS) accounted for 0.03% before surgery. VHD patients are related to the following characteristics: female patients (odds ratio [OR]=1.15 [1.12–1.18]), elective admission (OR=0.78 [0.76–0.80]), Charlson Comorbidity Index ≥3 (OR=1.06 [1.03–1.08]), large-volume hospitals (OR=1.13 [1.1–1.2]), teaching hospitals (OR=5 4.4 [2.9–6.7]), and hospital location in urban areas (OR=1.22 [1.2–1.3]). In addition, VHD is a risk factor for mortality and some acute postoperative medical complications, such as acute cardiac event (OR=2.96 [2.87–3.04]), acute pulmonary edema (OR=1.13 [1.06–1.21]), acute cerebrovascular event (OR=1.22 [1.16–1.74]), and acute renal failure (OR=1.22 [1.17–1.27]). It also has an impact on DVT/PE (OR=0.89 [0.8–0.99]). Patients with AS before hip replacement have basic demographic characteristics similar to those of TJA patients with valvular disease. Patients with AS are older (≥80 years) than those without AS before surgery (OR=3.28 [2.27–4.75) and have the following characteristics: female patients (OR=1.92 [1.32–2.8]) and elective admission (OR=0.51 [0.36–0.75]). The perioperative period is limited to acute postoperative complications, such as acute cardiac events (OR=2.50 [1.76–3.53]) and acute hepatic failure (OR=7.69 [1.8–32.89]). Both valvular diseases and AS are associated with a higher mortality rate and hospitalization cost.
Conclusion
Valvular heart disease (VHD) independently predicted mortality rate and surgical and medical complications after total/partial hip arthroplasty.
Keywords
Valvular Heart Disease, Hip Replacement, aortic stenosis
Figure 1
Figure 2
Figure 3
No competing interests reported.
This is a list of supplementary files associated with this preprint. Click to download.
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CURRENT STATUS: Under Review
Version 1
Posted 23 Apr, 2021
No community comments so far
Editorial decision: Major revision
On 10 Jul, 2021
Reviews received
Received 20 May, 2021
Reviews received
Received 08 May, 2021
Reviewers agreed
On 06 May, 2021
Reviewers agreed
On 21 Apr, 2021
Reviewers invited
Invitations sent on 21 Apr, 2021
Editor assigned
On 21 Apr, 2021
Editor invited
On 20 Apr, 2021
Submission checks complete
On 20 Apr, 2021
First submitted
On 14 Apr, 2021
Metrics
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PDF Downloads: ...
HTML Views: ...
Subject Areas
Orthopedics
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This preprint is under consideration at BMC Musculoskeletal Disorders. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Yang Zhang
Nanfang Hospital
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 23 Apr, 2021
No community comments so far
Editorial decision: Major revision
On 10 Jul, 2021
Reviews received
Received 20 May, 2021
Reviews received
Received 08 May, 2021
Reviewers agreed
On 06 May, 2021
Reviewers agreed
On 21 Apr, 2021
Reviewers invited
Invitations sent on 21 Apr, 2021
Editor assigned
On 21 Apr, 2021
Editor invited
On 20 Apr, 2021
Submission checks complete
On 20 Apr, 2021
First submitted
On 14 Apr, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Orthopedics
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
To study the impact of valvular heart disease (VHD) on joint replacement, particularly the clinical impactions of aortic stenosis before total/partial hip arthroplasty.
Methods
This was a retrospective cohort study. Data on patients who had undergone joint replacement from 2005 to 2014 were extracted from the NIS database. Linear regression was used to analyze the essential characteristics of patients. Multivariate regression was used to estimate the correlation among demographics, comorbidities, complications, hospitalization costs, and time.
Results
Of the hip replacement surgeries, VHDs accounted for 5.56% and aortic stenosis (AS) accounted for 0.03% before surgery. VHD patients are related to the following characteristics: female patients (odds ratio [OR]=1.15 [1.12–1.18]), elective admission (OR=0.78 [0.76–0.80]), Charlson Comorbidity Index ≥3 (OR=1.06 [1.03–1.08]), large-volume hospitals (OR=1.13 [1.1–1.2]), teaching hospitals (OR=5 4.4 [2.9–6.7]), and hospital location in urban areas (OR=1.22 [1.2–1.3]). In addition, VHD is a risk factor for mortality and some acute postoperative medical complications, such as acute cardiac event (OR=2.96 [2.87–3.04]), acute pulmonary edema (OR=1.13 [1.06–1.21]), acute cerebrovascular event (OR=1.22 [1.16–1.74]), and acute renal failure (OR=1.22 [1.17–1.27]). It also has an impact on DVT/PE (OR=0.89 [0.8–0.99]). Patients with AS before hip replacement have basic demographic characteristics similar to those of TJA patients with valvular disease. Patients with AS are older (≥80 years) than those without AS before surgery (OR=3.28 [2.27–4.75) and have the following characteristics: female patients (OR=1.92 [1.32–2.8]) and elective admission (OR=0.51 [0.36–0.75]). The perioperative period is limited to acute postoperative complications, such as acute cardiac events (OR=2.50 [1.76–3.53]) and acute hepatic failure (OR=7.69 [1.8–32.89]). Both valvular diseases and AS are associated with a higher mortality rate and hospitalization cost.
Conclusion
Valvular heart disease (VHD) independently predicted mortality rate and surgical and medical complications after total/partial hip arthroplasty.
Figure 1
Figure 2
Figure 3
No competing interests reported.
This is a list of supplementary files associated with this preprint. Click to download.
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