This preprint is under consideration at Trials. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research
Timothy Ryan Smith
University of Kansas Medical Center
Corresponding Author
ORCiD: https://orcid.org/0000-0001-9607-8985
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
Clinical trials are the gold standard for assessing the effectiveness and safety of treatments. The objective of the current study was to assess provider opinions regarding implementing pediatric clinical trials in various practice settings across Kansas.
Methods
The study was completed within the Sunflower Pediatric Clinical Trials Research Extension (SPeCTRE), an affiliate of the IDeA States Pediatric Clinical Trials Network (ISPCTN). A cross-sectional, 36-item survey was administered to a state-wide convenience sample targeting health care providers and clinic staff.
Results
A total of 119 health care providers and clinic staff completed surveys; 31% were physicians. Physicians were more likely than other clinic staff to have experience with clinical trials (correlation coefficient [CC]=0.270, p=0.004). When compared to urban respondents, rural providers were less supportive of recruitment for clinical trials in their practices (CC=-0.251, p=0.008) and more likely to feel comfortable referring patients for clinical trials involving treatments that their insurance did not cover (CC=0.302, p=0.001).
Conclusion
A range of rural and urban health care professionals support the performance of pediatric clinical trials but identify several barriers as well. These results will support future pediatric clinical trials across the country including Kansas.
TRIAL REGISTRATION: NA
Keywords
clinical trials, pediatrics, providers, engagement, enrollment
Figure 1
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CURRENT STATUS: Under Review
Version 1
Posted 14 Jun, 2021
No community comments so far
Review #1 received
Received 06 Jul, 2021
Reviewer #3 agreed
On 04 Jul, 2021
Reviewer #2 agreed
On 04 Jul, 2021
Reviewer #1 agreed
On 01 Jul, 2021
Reviews received
Received 01 Jul, 2021
Reviewers invited
Invitations sent on 16 Jun, 2021
Editor assigned
On 16 Jun, 2021
Submission checks complete
On 12 Jun, 2021
First submitted
On 20 Sep, 2020
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This preprint is under consideration at Trials. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research
Timothy Ryan Smith
University of Kansas Medical Center
Corresponding Author
ORCiD: https://orcid.org/0000-0001-9607-8985
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 14 Jun, 2021
No community comments so far
Review #1 received
Received 06 Jul, 2021
Reviewer #3 agreed
On 04 Jul, 2021
Reviewer #2 agreed
On 04 Jul, 2021
Reviewer #1 agreed
On 01 Jul, 2021
Reviews received
Received 01 Jul, 2021
Reviewers invited
Invitations sent on 16 Jun, 2021
Editor assigned
On 16 Jun, 2021
Submission checks complete
On 12 Jun, 2021
First submitted
On 20 Sep, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
Clinical trials are the gold standard for assessing the effectiveness and safety of treatments. The objective of the current study was to assess provider opinions regarding implementing pediatric clinical trials in various practice settings across Kansas.
Methods
The study was completed within the Sunflower Pediatric Clinical Trials Research Extension (SPeCTRE), an affiliate of the IDeA States Pediatric Clinical Trials Network (ISPCTN). A cross-sectional, 36-item survey was administered to a state-wide convenience sample targeting health care providers and clinic staff.
Results
A total of 119 health care providers and clinic staff completed surveys; 31% were physicians. Physicians were more likely than other clinic staff to have experience with clinical trials (correlation coefficient [CC]=0.270, p=0.004). When compared to urban respondents, rural providers were less supportive of recruitment for clinical trials in their practices (CC=-0.251, p=0.008) and more likely to feel comfortable referring patients for clinical trials involving treatments that their insurance did not cover (CC=0.302, p=0.001).
Conclusion
A range of rural and urban health care professionals support the performance of pediatric clinical trials but identify several barriers as well. These results will support future pediatric clinical trials across the country including Kansas.
TRIAL REGISTRATION: NA
Figure 1
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