This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Original investigation
C Sun
Harbin Medical University
Corresponding Author
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This work is licensed under a CC BY 4.0 License. Read Full License
Background: This study aimed to elucidate whether dietary amino acids (AAs) composition is associated with type 2 diabetes mellitus (T2DM), and to investigate whether and how serum AAs profiles mediated this association.
Methods: Two prospective cohorts of 1750 and 4024 adults aged 20-74 year-old were enrolled with mean values of 4.2 and 5.3 years follow-up. Dietary AAs compositions index (AACI) was developed to reflect the overall quality of dietary AAs composition with the lower the AACI value, the higher quality of dietary AAs compositions. Multivariate linear regression and logistic regression models were used to examine associations of AACI with serum AAs profiles and incidence of T2DM.
Results: The AACI was associated with the incidence of T2DM with the relative risk and 95%CI from the bottom to the top tertiles being 1.00, 1.39 (0.85-2.26) and 1.68 (1.01-2.91), and 1.00, 1.30 (0.98-1.34) and 1.63 (1.19-2.23) in the two cohorts, respectively. The AACI was positively associated with serum valine, isoleucine, glutamic acid and phenylalanine, and it was negatively associated with serum glycine and histidine in both cohorts (P<0.01). Among these serum AAs, valine, glutamic acid and histidine consistently and partially mediated the association between the AACI and incidence of T2DM in the two cohorts, with total mediation effects of 33.4% and 54.6%, respectively.
Conclusion: Dietary AAs composition was associated with the incidence of T2DM through influencing its serum profiles. Future dietary strategies for prevention and treatment of T2DM should focus on improvement of overall quality of dietary AAs compositions.
Keywords
Amino acids, compositions, quality index, type 2 diabetes mellitus
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Original investigation
C Sun
Harbin Medical University
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 24 Jul, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: This study aimed to elucidate whether dietary amino acids (AAs) composition is associated with type 2 diabetes mellitus (T2DM), and to investigate whether and how serum AAs profiles mediated this association.
Methods: Two prospective cohorts of 1750 and 4024 adults aged 20-74 year-old were enrolled with mean values of 4.2 and 5.3 years follow-up. Dietary AAs compositions index (AACI) was developed to reflect the overall quality of dietary AAs composition with the lower the AACI value, the higher quality of dietary AAs compositions. Multivariate linear regression and logistic regression models were used to examine associations of AACI with serum AAs profiles and incidence of T2DM.
Results: The AACI was associated with the incidence of T2DM with the relative risk and 95%CI from the bottom to the top tertiles being 1.00, 1.39 (0.85-2.26) and 1.68 (1.01-2.91), and 1.00, 1.30 (0.98-1.34) and 1.63 (1.19-2.23) in the two cohorts, respectively. The AACI was positively associated with serum valine, isoleucine, glutamic acid and phenylalanine, and it was negatively associated with serum glycine and histidine in both cohorts (P<0.01). Among these serum AAs, valine, glutamic acid and histidine consistently and partially mediated the association between the AACI and incidence of T2DM in the two cohorts, with total mediation effects of 33.4% and 54.6%, respectively.
Conclusion: Dietary AAs composition was associated with the incidence of T2DM through influencing its serum profiles. Future dietary strategies for prevention and treatment of T2DM should focus on improvement of overall quality of dietary AAs compositions.
Figure 1
Figure 2
This is a list of supplementary files associated with this preprint. Click to download.
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