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Research Article
Chao Yan
Wuhan Textile University
Corresponding Author
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In this study, novel cellulose/carboxymethyl chitosan (CMCS) composite hydrogels were constructed by blending cellulose and CMCS in LiOH/urea aqueous solutions, and then cross-linking with epichlorohydrin. The structure and morphology of the composite hydrogels were characterized by Fourier transform infrared spectroscopy (FT-IR), wide-angle X-ray diffraction (WXRD), thermo-gravimetric analysis (TGA), and scanning electron microscopy (SEM). The results revealed that the chemical cross-linking reaction between cellulose and CMCS occurred in the hydrogel, and CMCS contributed to the enhancement of pore size, whereas cellulose as a strong backbone in the hydrogel to support the pore wall. The mechanical strength of the composite hydrogels increased with the cellulose content, while the equilibrium swelling ratio and antibacterial activity increased with the CMCS content. The composite hydrogels had no cytotoxicity towards L929 cells, suggesting good biocompatibility. All these results indicate that cellulose/CMCS composite hydrogels can be effectively used as a material in wound dressing.
Keywords
Cellulose, Carboxymethyl chitosan, LiOH/urea aqueous solutions, Hydrogels, Wound dressing
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CURRENT STATUS: Under Review
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Posted 12 Jul, 2021
Reviews received
Received 12 Jul, 2021
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Editor invited
On 12 Jul, 2021
First submitted
On 11 Jul, 2021
Version 1
Posted 30 Apr, 2021
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Reviews received
Received 27 Apr, 2021
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This preprint is under consideration at Cellulose. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Chao Yan
Wuhan Textile University
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version (no preprint)
Posted 12 Jul, 2021
Reviews received
Received 12 Jul, 2021
Reviewers invited
Invitations sent on 12 Jul, 2021
Editor invited
On 12 Jul, 2021
First submitted
On 11 Jul, 2021
Version 1
Posted 30 Apr, 2021
No community comments so far
Reviews received
Received 27 Apr, 2021
Reviewers invited
Invitations sent on 27 Apr, 2021
First submitted
On 13 Apr, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
In this study, novel cellulose/carboxymethyl chitosan (CMCS) composite hydrogels were constructed by blending cellulose and CMCS in LiOH/urea aqueous solutions, and then cross-linking with epichlorohydrin. The structure and morphology of the composite hydrogels were characterized by Fourier transform infrared spectroscopy (FT-IR), wide-angle X-ray diffraction (WXRD), thermo-gravimetric analysis (TGA), and scanning electron microscopy (SEM). The results revealed that the chemical cross-linking reaction between cellulose and CMCS occurred in the hydrogel, and CMCS contributed to the enhancement of pore size, whereas cellulose as a strong backbone in the hydrogel to support the pore wall. The mechanical strength of the composite hydrogels increased with the cellulose content, while the equilibrium swelling ratio and antibacterial activity increased with the CMCS content. The composite hydrogels had no cytotoxicity towards L929 cells, suggesting good biocompatibility. All these results indicate that cellulose/CMCS composite hydrogels can be effectively used as a material in wound dressing.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
Figure 9
Figure 10
Figure 11
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