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Research Article
Ping Liu
Liyuan Hospital of Tongji Medical College of Huazhong University of Science and Technology
Corresponding Author
ORCiD: https://orcid.org/0000-0002-7103-1790
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Abnormalities in serum lipids and lipoproteins have been documented to be associated with the risk of various cancers in recent years, but its prognostic value for cancer is not known. This study retrospectively evaluated the prognostic significance of preoperative serum lipids and lipoproteins for non-small cell lung cancer (NSCLC).
Methods: A retrospective review was conducted of 551 patients with NSCLC. A receiver operative characteristic (ROC) curve was utilized to determine the optimal cut-off value and area under the ROC curve. Kaplan-Meier curves and a Cox proportional hazards model were used to perform survival analysis.
Results: Serum lipids and lipoproteins had significant difference between NSCLC patients and healthy controls. Moreover, with a median follow-up of 42 months, the NSCLC patients in high triglycerides (TG) group and low High-density lipoprotein cholesterol (HDL-C) group exhibited shorter overall survival (OS) and disease-free survival (DFS). In multivariable analysis, preoperative TG and HDL-C can be identified as independent prognostic factors for OS and DFS in patients with NSCLC.
Conclusion: Abnormalities of serum lipids and lipoproteins metabolism were associated with the survival outcomes of NSCLC. Preoperative serum TG and HDL-C may be promising biomarkers to predict prognosis for NSCLC patients.
Keywords
non-small cell lung cancer, triglycerides, high-density lipoprotein cholesterol, prognosis
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CURRENT STATUS: Under Review
Version 1
Posted 19 Apr, 2021
No community comments so far
Editorial decision: Major revision
On 16 May, 2021
Review #6 received
Received 15 May, 2021
Review #5 received
Received 08 May, 2021
Reviewer #7 agreed
On 04 May, 2021
Review #7 received
Received 04 May, 2021
Reviewer #6 agreed
On 03 May, 2021
Review #3 received
Received 01 May, 2021
Review #4 received
Received 28 Apr, 2021
Reviewer #5 agreed
On 26 Apr, 2021
Reviewer #4 agreed
On 26 Apr, 2021
Review #1 received
Received 18 Apr, 2021
Review #2 received
Received 18 Apr, 2021
Reviewer #2 agreed
On 15 Apr, 2021
Reviewer #3 agreed
On 15 Apr, 2021
Reviews received
Received 15 Apr, 2021
Reviewer #1 agreed
On 15 Apr, 2021
Reviewers invited
Invitations sent on 15 Apr, 2021
Editor assigned
On 14 Apr, 2021
Submission checks complete
On 14 Apr, 2021
Editor invited
On 14 Apr, 2021
First submitted
On 14 Apr, 2021
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This preprint is under consideration at Lipids in Health and Disease. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Ping Liu
Liyuan Hospital of Tongji Medical College of Huazhong University of Science and Technology
Corresponding Author
ORCiD: https://orcid.org/0000-0002-7103-1790
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 19 Apr, 2021
No community comments so far
Editorial decision: Major revision
On 16 May, 2021
Review #6 received
Received 15 May, 2021
Review #5 received
Received 08 May, 2021
Reviewer #7 agreed
On 04 May, 2021
Review #7 received
Received 04 May, 2021
Reviewer #6 agreed
On 03 May, 2021
Review #3 received
Received 01 May, 2021
Review #4 received
Received 28 Apr, 2021
Reviewer #5 agreed
On 26 Apr, 2021
Reviewer #4 agreed
On 26 Apr, 2021
Review #1 received
Received 18 Apr, 2021
Review #2 received
Received 18 Apr, 2021
Reviewer #2 agreed
On 15 Apr, 2021
Reviewer #3 agreed
On 15 Apr, 2021
Reviews received
Received 15 Apr, 2021
Reviewer #1 agreed
On 15 Apr, 2021
Reviewers invited
Invitations sent on 15 Apr, 2021
Editor assigned
On 14 Apr, 2021
Submission checks complete
On 14 Apr, 2021
Editor invited
On 14 Apr, 2021
First submitted
On 14 Apr, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Abnormalities in serum lipids and lipoproteins have been documented to be associated with the risk of various cancers in recent years, but its prognostic value for cancer is not known. This study retrospectively evaluated the prognostic significance of preoperative serum lipids and lipoproteins for non-small cell lung cancer (NSCLC).
Methods: A retrospective review was conducted of 551 patients with NSCLC. A receiver operative characteristic (ROC) curve was utilized to determine the optimal cut-off value and area under the ROC curve. Kaplan-Meier curves and a Cox proportional hazards model were used to perform survival analysis.
Results: Serum lipids and lipoproteins had significant difference between NSCLC patients and healthy controls. Moreover, with a median follow-up of 42 months, the NSCLC patients in high triglycerides (TG) group and low High-density lipoprotein cholesterol (HDL-C) group exhibited shorter overall survival (OS) and disease-free survival (DFS). In multivariable analysis, preoperative TG and HDL-C can be identified as independent prognostic factors for OS and DFS in patients with NSCLC.
Conclusion: Abnormalities of serum lipids and lipoproteins metabolism were associated with the survival outcomes of NSCLC. Preoperative serum TG and HDL-C may be promising biomarkers to predict prognosis for NSCLC patients.
Figure 1
Figure 2
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