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najmaldin saki
Ahvaz Jundishapur University of Medical Sciences
Corresponding Author
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Objective: Chronic lymphocytic leukemia (CLL) is an adult leukemia presented with clonal accumulation of lymphocytes. Immunophenotypic changes can be effective in predicting clinical course, the survival of patients, and determining first-line treatment. This is a study of the association between immunophenotypic markers with complete blood cell count (CBC) values and clinical parameters.
Results: Peripheral blood samples were collected from 35 newly diagnosed CLL patients. The expression of immunophenotypic markers and CBC were evaluated. Platelet counts and hemoglobin concentration had a significant, inverse association with Rai staging, modified Rai staging, Binet staging systems (all p< 0.001 in both parameters), and splenomegaly (p = 0.001 and 0.007, respectively). The platelet/lymphocyte ratio (PLR) had a significant, inverse association with Rai staging (p = 0.014), modified Rai staging (p = 0.024), Binet staging systems (p = 0.027), and splenomegaly (p = 0.033). However, CD38, CD25, and double-positive CD56/CD117 expression, group3 of innate lymphocyte cells (ILC3s), had no significant association with clinical parameters. In regression analysis, that ILC3s has an inverse correlation with neutrophil/lymphocyte ratio (r = -0.340, p = 0.046). Given that there is an inverse association between PLR and advanced clinical stages, it seems that PLR may have prognostic value in CLL.
Keywords
Chronic lymphocytic leukemia, Immunophenotypic markers, Clinical parameters, Blood cell count, Prognosis
This is a list of supplementary files associated with this preprint. Click to download.
- SupplementaryFig.1a.tif
Representative flow cytometry profiles of immunophenotypic markers expression in patients with CLL. a) Sample of CD38 and CD25 expression. b) Sample of double-positive CD56/CD117 expression.
- SupplementaryFig.1b.tif
Representative flow cytometry profiles of immunophenotypic markers expression in patients with CLL. a) Sample of CD38 and CD25 expression. b) Sample of double-positive CD56/CD117 expression.
- SupplementaryFig.2.tif
A significant, negative correlation between double-positive CD56/CD117 expression with neutrophil/lymphocyte ration (NLR) (r = -0.340, p = 0.046) in CLL patients.
- SupplementaryFig.3.tif
A non-significant, negative correlation between double-positive CD56/CD117 expression with platelet/lymphocyte ration (PLR) (r = -0.264, p = 0.125) in CLL patients.
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CURRENT STATUS: Published
View the published article at BMC Research Notes.
Version 2
Posted 18 Aug, 2020
No community comments so far
Editorial decision: Accept
On 17 Aug, 2020
Editor assigned
On 14 Aug, 2020
Submission checks complete
On 13 Aug, 2020
Editor invited
On 13 Aug, 2020
No comments provided
Editorial decision: Minor revision
On 09 Aug, 2020
Review #1 received
Received 01 Aug, 2020
Reviewer #1 agreed
On 24 Jul, 2020
Editor assigned
On 20 Jul, 2020
Reviewers invited
Invitations sent on 20 Jul, 2020
Submission checks complete
On 15 Jul, 2020
Editor invited
On 13 Jul, 2020
First submitted
On 11 Jul, 2020
Metrics
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PDF Downloads: ...
HTML Views: ...
Subject Areas
Oncology
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See the published version of this preprint at BMC Research Notes.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research note
najmaldin saki
Ahvaz Jundishapur University of Medical Sciences
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Research Notes.
Version 2
Posted 18 Aug, 2020
No community comments so far
Editorial decision: Accept
On 17 Aug, 2020
Editor assigned
On 14 Aug, 2020
Submission checks complete
On 13 Aug, 2020
Editor invited
On 13 Aug, 2020
No comments provided
Editorial decision: Minor revision
On 09 Aug, 2020
Review #1 received
Received 01 Aug, 2020
Reviewer #1 agreed
On 24 Jul, 2020
Editor assigned
On 20 Jul, 2020
Reviewers invited
Invitations sent on 20 Jul, 2020
Submission checks complete
On 15 Jul, 2020
Editor invited
On 13 Jul, 2020
First submitted
On 11 Jul, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Oncology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Research Notes.
Objective: Chronic lymphocytic leukemia (CLL) is an adult leukemia presented with clonal accumulation of lymphocytes. Immunophenotypic changes can be effective in predicting clinical course, the survival of patients, and determining first-line treatment. This is a study of the association between immunophenotypic markers with complete blood cell count (CBC) values and clinical parameters.
Results: Peripheral blood samples were collected from 35 newly diagnosed CLL patients. The expression of immunophenotypic markers and CBC were evaluated. Platelet counts and hemoglobin concentration had a significant, inverse association with Rai staging, modified Rai staging, Binet staging systems (all p< 0.001 in both parameters), and splenomegaly (p = 0.001 and 0.007, respectively). The platelet/lymphocyte ratio (PLR) had a significant, inverse association with Rai staging (p = 0.014), modified Rai staging (p = 0.024), Binet staging systems (p = 0.027), and splenomegaly (p = 0.033). However, CD38, CD25, and double-positive CD56/CD117 expression, group3 of innate lymphocyte cells (ILC3s), had no significant association with clinical parameters. In regression analysis, that ILC3s has an inverse correlation with neutrophil/lymphocyte ratio (r = -0.340, p = 0.046). Given that there is an inverse association between PLR and advanced clinical stages, it seems that PLR may have prognostic value in CLL.
This is a list of supplementary files associated with this preprint. Click to download.
- SupplementaryFig.1a.tif
Representative flow cytometry profiles of immunophenotypic markers expression in patients with CLL. a) Sample of CD38 and CD25 expression. b) Sample of double-positive CD56/CD117 expression.
- SupplementaryFig.1b.tif
Representative flow cytometry profiles of immunophenotypic markers expression in patients with CLL. a) Sample of CD38 and CD25 expression. b) Sample of double-positive CD56/CD117 expression.
- SupplementaryFig.2.tif
A significant, negative correlation between double-positive CD56/CD117 expression with neutrophil/lymphocyte ration (NLR) (r = -0.340, p = 0.046) in CLL patients.
- SupplementaryFig.3.tif
A non-significant, negative correlation between double-positive CD56/CD117 expression with platelet/lymphocyte ration (PLR) (r = -0.264, p = 0.125) in CLL patients.
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