1 Center, M. M. et al. International variation in prostate cancer incidence and mortality rates. European urology 61, 1079-1092, doi:10.1016/j.eururo.2012.02.054 (2012).
2 Siegel, R. L., Miller, K. D. & Jemal, A. Cancer statistics, 2015. CA: a cancer journal for clinicians 65, 5-29, doi:10.3322/caac.21254 (2015).
3 Coffelt, S. B. et al. Elusive identities and overlapping phenotypes of proangiogenic myeloid cells in tumors. The American journal of pathology 176, 1564-1576, doi:10.2353/ajpath.2010.090786 (2010).
4 Campbell, M. J. et al. The prognostic implications of macrophages expressing proliferating cell nuclear antigen in breast cancer depend on immune context. PloS one 8, e79114, doi:10.1371/journal.pone.0079114 (2013).
5 Su, C. Y., Fu, X. L., Duan, W., Yu, P. W. & Zhao, Y. L. High density of CD68+ tumor-associated macrophages predicts a poor prognosis in gastric cancer mediated by IL-6 expression. Oncology letters 15, 6217-6224, doi:10.3892/ol.2018.8119 (2018).
6 Murray, P. J. Nonresolving macrophage-mediated inflammation in malignancy. The FEBS journal 285, 641-653, doi:10.1111/febs.14210 (2018).
7 Van Overmeire, E., Laoui, D., Keirsse, J., Van Ginderachter, J. A. & Sarukhan, A. Mechanisms driving macrophage diversity and specialization in distinct tumor microenvironments and parallelisms with other tissues. Frontiers in immunology 5, 127, doi:10.3389/fimmu.2014.00127 (2014).
8 Qian, B. Z. & Pollard, J. W. Macrophage diversity enhances tumor progression and metastasis. Cell 141, 39-51, doi:10.1016/j.cell.2010.03.014 (2010).
9 Wilson, H. M. SOCS Proteins in Macrophage Polarization and Function. Frontiers in immunology 5, 357, doi:10.3389/fimmu.2014.00357 (2014).
10 Neuwirt, H. et al. Suppressor of cytokine signaling (SOCS)-1 is expressed in human prostate cancer and exerts growth-inhibitory function through down-regulation of cyclins and cyclin-dependent kinases. The American journal of pathology 174, 1921-1930, doi:10.2353/ajpath.2009.080751 (2009).
11 Mansoori, B. et al. miR-142-3p as tumor suppressor miRNA in the regulation of tumorigenicity, invasion and migration of human breast cancer by targeting Bach-1 expression. Journal of cellular physiology 234, 9816-9825, doi:10.1002/jcp.27670 (2019).
12 Muller, S. et al. IGF2BP1 enhances an aggressive tumor cell phenotype by impairing miRNA-directed downregulation of oncogenic factors. Nucleic acids research 46, 6285-6303, doi:10.1093/nar/gky229 (2018).
13 Lu, C. et al. miR-221 and miR-155 regulate human dendritic cell development, apoptosis, and IL-12 production through targeting of p27kip1, KPC1, and SOCS-1. Blood 117, 4293-4303, doi:10.1182/blood-2010-12-322503 (2011).
14 Zhao, B. et al. MicroRNA let-7c inhibits migration and invasion of human non-small cell lung cancer by targeting ITGB3 and MAP4K3. Cancer letters 342, 43-51, doi:10.1016/j.canlet.2013.08.030 (2014).
15 Wang, Y. et al. Genomic DNA copy-number alterations of the let-7 family in human cancers. PloS one 7, e44399, doi:10.1371/journal.pone.0044399 (2012).
16 Kumar, M. et al. MicroRNA let-7 modulates the immune response to Mycobacterium tuberculosis infection via control of A20, an inhibitor of the NF-kappaB pathway. Cell host & microbe 17, 345-356, doi:10.1016/j.chom.2015.01.007 (2015).
17 Wang, Z. et al. miRNA let-7b modulates macrophage polarization and enhances tumor-associated macrophages to promote angiogenesis and mobility in prostate cancer. Scientific reports 6, 25602, doi:10.1038/srep25602 (2016).
18 Murray, P. J. et al. Macrophage activation and polarization: nomenclature and experimental guidelines. Immunity 41, 14-20, doi:10.1016/j.immuni.2014.06.008 (2014).
19 Gollapudi, K. et al. Association between tumor-associated macrophage infiltration, high grade prostate cancer, and biochemical recurrence after radical prostatectomy. American journal of cancer research 3, 523-529 (2013).
20 Copeland, B. T. et al. Imaging and Characterization of Macrophage Distribution in Mouse Models of Human Prostate Cancer. Molecular imaging and biology 21, 1054-1063, doi:10.1007/s11307-019-01318-5 (2019).
21 Nonomura, N. et al. Infiltration of tumour-associated macrophages in prostate biopsy specimens is predictive of disease progression after hormonal therapy for prostate cancer. BJU international 107, 1918-1922, doi:10.1111/j.1464-410X.2010.09804.x (2011).
22 Calin, G. A. et al. Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proceedings of the National Academy of Sciences of the United States of America 101, 2999-3004, doi:10.1073/pnas.0307323101 (2004).
23 Kim, A., Saikia, P. & Nagy, L. E. miRNAs Involved in M1/M2 Hyperpolarization Are Clustered and Coordinately Expressed in Alcoholic Hepatitis. Frontiers in immunology 10, 1295, doi:10.3389/fimmu.2019.01295 (2019).
24 Pobezinsky, L. A. & Wells, A. C. Let's fight cancer: let-7 is a tool to enhance antitumor immune responses. Future oncology 14, 1141-1145, doi:10.2217/fon-2018-0037 (2018).
25 Xiao, G. et al. The Long Noncoding RNA TTTY15, Which Is Located on the Y Chromosome, Promotes Prostate Cancer Progression by Sponging let-7. European urology 76, 315-326, doi:10.1016/j.eururo.2018.11.012 (2019).
26 Kang, M. et al. Concurrent treatment with simvastatin and NF-kappaB inhibitor in human castration-resistant prostate cancer cells exerts synergistic anti-cancer effects via control of the NF-kappaB/LIN28/let-7 miRNA signaling pathway. PloS one 12, e0184644, doi:10.1371/journal.pone.0184644 (2017).
27 Banerjee, S. et al. MicroRNA let-7c regulates macrophage polarization. Journal of immunology 190, 6542-6549, doi:10.4049/jimmunol.1202496 (2013).
28 Linossi, E. M. & Nicholson, S. E. Kinase inhibition, competitive binding and proteasomal degradation: resolving the molecular function of the suppressor of cytokine signaling (SOCS) proteins. Immunological reviews 266, 123-133, doi:10.1111/imr.12305 (2015).
29 Hu, J. et al. Suppressors of cytokine signalling (SOCS)-1 inhibits neuroinflammation by regulating ROS and TLR4 in BV2 cells. Inflammation research : official journal of the European Histamine Research Society ... [et al.], doi:10.1007/s00011-019-01289-x (2019).
30 McCormick, S. M., Gowda, N., Fang, J. X. & Heller, N. M. Suppressor of Cytokine Signaling (SOCS)1 Regulates Interleukin-4 (IL-4)-activated Insulin Receptor Substrate (IRS)-2 Tyrosine Phosphorylation in Monocytes and Macrophages via the Proteasome. The Journal of biological chemistry 291, 20574-20587, doi:10.1074/jbc.M116.746164 (2016).
31 Liau, N. P. D. et al. The molecular basis of JAK/STAT inhibition by SOCS1. Nature communications 9, 1558, doi:10.1038/s41467-018-04013-1 (2018).
32 Liang, Y. B. et al. Downregulated SOCS1 expression activates the JAK1/STAT1 pathway and promotes polarization of macrophages into M1 type. Molecular medicine reports 16, 6405-6411, doi:10.3892/mmr.2017.7384 (2017).
33 Yin, Z. et al. IL-6/STAT3 pathway intermediates M1/M2 macrophage polarization during the development of hepatocellular carcinoma. Journal of cellular biochemistry 119, 9419-9432, doi:10.1002/jcb.27259 (2018).
34 Maruoka, M., Kedashiro, S., Ueda, Y., Mizutani, K. & Takai, Y. Nectin-4 co-stimulates the prolactin receptor by interacting with SOCS1 and inhibiting its activity on the JAK2-STAT5a signaling pathway. The Journal of biological chemistry 292, 6895-6909, doi:10.1074/jbc.M116.769091 (2017).
35 Recio, C. et al. Gene delivery of suppressors of cytokine signaling (SOCS) inhibits inflammation and atherosclerosis development in mice. Basic research in cardiology 110, 8, doi:10.1007/s00395-014-0458-1 (2015).
36 Jacobsson, H. et al. Hypoxia-induced secretion stimulates breast cancer stem cell regulatory signalling pathways. Molecular oncology 13, 1693-1705, doi:10.1002/1878-0261.12500 (2019).
37 Lv, R., Bao, Q. & Li, Y. Regulation of M1type and M2type macrophage polarization in RAW264.7 cells by Galectin9. Molecular medicine reports 16, 9111-9119, doi:10.3892/mmr.2017.7719 (2017).
38 Dang, T. & Liou, G. Y. Macrophage Cytokines Enhance Cell Proliferation of Normal Prostate Epithelial Cells through Activation of ERK and Akt. Scientific reports 8, 7718, doi:10.1038/s41598-018-26143-8 (2018).
39 Wang, M., Hu, Y. & Stearns, M. E. A novel IL-10 signalling mechanism regulates TIMP-1 expression in human prostate tumour cells. British journal of cancer 88, 1605-1614, doi:10.1038/sj.bjc.6600855 (2003).
40 Stearns, M. E., Hu, Y. & Wang, M. IL-10 signaling via IL-10E1 is dependent on tyrosine phosphorylation in the IL-10R alpha chain in human primary prostate cancer cell lines. Oncogene 22, 3781-3791, doi:10.1038/sj.onc.1206579 (2003).
41 Gurusamy, D., Shoe, J., Hocker, J. & Hurwitz, A. A role for IL-13 in the progression of prostate tumors (TUM10P.1046). Journal of immunology 194 (2015).
42 Moore, R. J. et al. Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis. Nature medicine 5, 828-831, doi:10.1038/10552 (1999).
43 Pikarsky, E. et al. NF-kappaB functions as a tumour promoter in inflammation-associated cancer. Nature 431, 461-466, doi:10.1038/nature02924 (2004).
44 Akhtar, N. et al. Interleukin-12 inhibits tumor growth in a novel angiogenesis canine hemangiosarcoma xenograft model. Neoplasia 6, 106-116, doi:10.1593/neo.03334 (2004).
45 Yan, J., Smyth, M. J. & Teng, M. W. L. Interleukin (IL)-12 and IL-23 and Their Conflicting Roles in Cancer. Cold Spring Harbor perspectives in biology 10, doi:10.1101/cshperspect.a028530 (2018).