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Research Article
Francisco Jose Sanchez Torralvo
Unidad de Gestión Clínica de Endocrinología y Nutrición. Hospital Regional Universitario de Malaga
Corresponding Author
ORCiD: https://orcid.org/0000-0002-0739-2567
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This work is licensed under a CC BY 4.0 License. Read Full License
Background
Anxiety and depression are a common issue in patients with cancer, yet understudied among hospitalized patients. The aim of this study was to estimate the prevalence of anxiety and depression symptomatology in cancer inpatients and its relationship with malnutrition.
Methods
Cross-sectional study in hospitalized cancer patients. A nutritional assessment was done using GLIM criteria to diagnose malnutrition. Data regarding anxiety and depression symptomatology was obtained with the Hospital Anxiety and Depression Scale (HADS).
Results
A total of 282 inpatients were assessed. GLIM criteria found 20% (66) of well-nourished and 80% (216) with malnutrition. HADS presented an average score of 8.3±4.4 with respect to anxiety and an average score of 7.7 ± 4.6 with respect to depression. 54 % showed a possible presence of anxiety and 45.3% showed a possible presence of depression.
In malnourished patients, HADS score tended to be higher with respect to anxiety (8.5±4.3 in malnourished vs 7.1 ± 4.6 in well-nourished; p=0.06) and was significantly higher with respect to depression (8.2 ± 4.6 in malnourished vs 5.3 ± 4.0 in well-nourished; p<0.001).
After controlling for potential confounders, malnourished patients were 1.98 times more likely to present anxious symptomatology (95% CI 1.01-3.98; p=0.049) and 6.29 times more likely to present depressive symptomatology (95% CI 1.73-20.47; p=0.005).
Conclusions
The presence of anxiety and depression symptomatology in oncological inpatients is high. There is an association between malnutrition and presenting anxious and depressive symptomatology in hospitalized cancer patients.
Keywords
Cancer, Oncology, Anxiety, Depression, HADS, Malnutrition, GLIM Criteria
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This preprint is under consideration at Supportive Care in Cancer. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Francisco Jose Sanchez Torralvo
Unidad de Gestión Clínica de Endocrinología y Nutrición. Hospital Regional Universitario de Malaga
Corresponding Author
ORCiD: https://orcid.org/0000-0002-0739-2567
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 27 May, 2021
No community comments so far
Reviews received
Received 25 May, 2021
Reviewers invited
Invitations sent on 24 May, 2021
First submitted
On 14 Apr, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
Anxiety and depression are a common issue in patients with cancer, yet understudied among hospitalized patients. The aim of this study was to estimate the prevalence of anxiety and depression symptomatology in cancer inpatients and its relationship with malnutrition.
Methods
Cross-sectional study in hospitalized cancer patients. A nutritional assessment was done using GLIM criteria to diagnose malnutrition. Data regarding anxiety and depression symptomatology was obtained with the Hospital Anxiety and Depression Scale (HADS).
Results
A total of 282 inpatients were assessed. GLIM criteria found 20% (66) of well-nourished and 80% (216) with malnutrition. HADS presented an average score of 8.3±4.4 with respect to anxiety and an average score of 7.7 ± 4.6 with respect to depression. 54 % showed a possible presence of anxiety and 45.3% showed a possible presence of depression.
In malnourished patients, HADS score tended to be higher with respect to anxiety (8.5±4.3 in malnourished vs 7.1 ± 4.6 in well-nourished; p=0.06) and was significantly higher with respect to depression (8.2 ± 4.6 in malnourished vs 5.3 ± 4.0 in well-nourished; p<0.001).
After controlling for potential confounders, malnourished patients were 1.98 times more likely to present anxious symptomatology (95% CI 1.01-3.98; p=0.049) and 6.29 times more likely to present depressive symptomatology (95% CI 1.73-20.47; p=0.005).
Conclusions
The presence of anxiety and depression symptomatology in oncological inpatients is high. There is an association between malnutrition and presenting anxious and depressive symptomatology in hospitalized cancer patients.
Figure 1
Figure 2
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