Surplus tetracycline (TC) in the water body causes damage to the ecology balance and human health. Therefore, an efficient strategy was proposed, namely, the UV-heterogeneous Fenton-like system with BiFeO3 (BFO) catalyst, to eliminate TC pollution. This work successfully integrated the photocatalytic oxidation system with the heterogeneous Fenton-like system, cooperating with the photolysis of H2O2. These coupled effects could boost the reduction of Fe (Ⅲ) to Fe (Ⅱ) and depress the recombination of photogenerated charges, further promoting the generation of reactive species, and ultimately facilitating the TC degradation and mineralization. The catalytic of the prepared BFO was stable with no secondary pollution, and BFO could be recovered by an extra magnet to reuse. Compared with other advanced oxidation processes, this system showed an outstanding performance in TC degradation and mineralization, and TC and TOC removal efficiencies could reach 100% and 74.92%, respectively. Moreover, the possible mechanisms for TC degradation involved that TC was degraded by oxidation species generated by the synergistic effect in this system, such as superoxide radicals (·O- 2), hydroxyl radicals (·OH), and positive holes (h+). Intermediate products in the TC degradation process mainly were products at m/z=459, m/z=445, and m/z=134.