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Research Article
Yara Ahmed muhammed
October University for Modern Sciences and Arts Faculty of Biotechnology
Corresponding Author
ORCiD: https://orcid.org/0000-0002-1350-9581
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Background: A cluster of many risk factors for type 2 diabetes and cardiovascular disease is used to describe the metabolic syndrome (MetS). Moreover, genetic differences associated with metabolic syndrome play a key role in its prevalence and side effects. This study aims to investigate the expression of DYRK1B and its association with metabolic syndrome in a small cohort of Egyptian.
Materials and methods: A total of 100 adult Egyptians (50 with MetS and 50 healthy control subjects) were included to this study. Clinical, biochemical and anthropometric analysis were assessed. Relative gene expressions of DYRK1B were compared between two groups of subjects using real time PCR.
Results: We observed marked overexpression in DYRK1B (p<0.05) in MetS subjects when compared with the healthy control subjects.
Conclusion: This is the first study to provide evidence that DYRK1B is highly expressed among the MetS subjects.
Keywords
Metabolic syndrome, Gene expression, DYRK1B, Real Time PCR
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Editorial decision: Minor Revisions Needed
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This preprint is under consideration at Molecular Biology Reports. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Yara Ahmed muhammed
October University for Modern Sciences and Arts Faculty of Biotechnology
Corresponding Author
ORCiD: https://orcid.org/0000-0002-1350-9581
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 02 Jul, 2021
No community comments so far
Reviewers invited
Invitations sent on 28 Jun, 2021
Reviews received
Received 28 Jun, 2021
Editor assigned
On 26 Jun, 2021
First submitted
On 26 Jun, 2021
Editorial decision: Minor Revisions Needed
On 09 Jun, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Molecular Biology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: A cluster of many risk factors for type 2 diabetes and cardiovascular disease is used to describe the metabolic syndrome (MetS). Moreover, genetic differences associated with metabolic syndrome play a key role in its prevalence and side effects. This study aims to investigate the expression of DYRK1B and its association with metabolic syndrome in a small cohort of Egyptian.
Materials and methods: A total of 100 adult Egyptians (50 with MetS and 50 healthy control subjects) were included to this study. Clinical, biochemical and anthropometric analysis were assessed. Relative gene expressions of DYRK1B were compared between two groups of subjects using real time PCR.
Results: We observed marked overexpression in DYRK1B (p<0.05) in MetS subjects when compared with the healthy control subjects.
Conclusion: This is the first study to provide evidence that DYRK1B is highly expressed among the MetS subjects.
Figure 1
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