See the published version of this preprint at Cancer Cell International.
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Primary research
Yuefeng Lu
Guangxi Medical University First Affiliated Hospital
Corresponding Author
License:
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Background
To date, no study has investigated the association of the WNT1 inducible signaling pathway protein-1 (WISP1) polymorphisms with susceptibility to gastric cancer. Therefore, we conducted this study to explore their relation.
Methods
204 gastric cancer patients and 227 normal controls were enrolled. The WISP1 SNPs rs2929973, rs7843546 and rs10956697 were selected, and their genotypic distributions were determined through PCR-RFLP
Results
In overall, we could not identify a significant association between WISP1 SNP rs2929973, rs7843546 and rs10956697) and gastric cancer risk. However, subgroup analysis demonstrated that the presence of the rs7843546 T allele was associated with a significantly decreased risk of gastric cancer in Han Chinese ethnicity (CT vs. CC: OR= 0.33, 95%CI = 0.14-0.78; TT vs. CC: OR = 0.29, 95%CI = 0.11-0.76; dominant model CT+TT vs. CC: OR = 0.32, 95%CI = 0.14-0.74). In addition, patients with the rs7843546 TT genotype were around one-third as 0.34 likely (OR = 0.34; 95% CI: 0.14-0.84) than those with the CC genotype to develop stage I/II gastric cancer. Furthermore, individuals ≥50 years old who carried the rs10956697 AC genotype represented significantly decreased risk for gastric cancer (AC vs. CC: OR = 0.58, 95%CI = 0.35-0.98). Smokers with the rs10956697 AC and AC+AA genotype were around one-third likely to develop gastric cancer (OR = 0.28, 95% CI= 0.09-0.82 and OR = 0.32, 95% CI = 0.12-0.89, respectively)
Conclusions
WISP1 SNPs rs7843546 and rs10956697 polymorphisms were the first time discovered to reduce the susceptibility to gastric cancer in different subgroup in Guangxi Chinese.
Keywords
WISP1, polymorphism, gastric cancer, risk
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View the published article at Cancer Cell International.
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On 02 Jun, 2021
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Received 01 Jun, 2021
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Received 18 May, 2021
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On 04 May, 2021
Reviewer #4 agreed
On 01 May, 2021
Reviewer #2 agreed
On 30 Apr, 2021
Reviewer #3 agreed
On 30 Apr, 2021
Editor invited
On 30 Apr, 2021
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Received 30 Apr, 2021
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Received 30 Apr, 2021
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On 30 Apr, 2021
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A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
See the published version of this preprint at Cancer Cell International.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Primary research
Yuefeng Lu
Guangxi Medical University First Affiliated Hospital
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at Cancer Cell International.
Version 1
Posted 04 May, 2021
No community comments so far
Review #10 received
Received 19 Jun, 2021
Editorial decision: Major revision
On 19 Jun, 2021
Review #9 received
Received 09 Jun, 2021
Review #8 received
Received 06 Jun, 2021
Review #6 received
Received 06 Jun, 2021
Review #7 received
Received 06 Jun, 2021
Reviewer #10 agreed
On 05 Jun, 2021
Reviewer #9 agreed
On 03 Jun, 2021
Reviewer #7 agreed
On 02 Jun, 2021
Reviewer #8 agreed
On 02 Jun, 2021
Reviewer #6 agreed
On 02 Jun, 2021
Review #4 received
Received 01 Jun, 2021
Review #2 received
Received 18 May, 2021
Review #3 received
Received 16 May, 2021
Review #5 received
Received 16 May, 2021
Reviewer #5 agreed
On 04 May, 2021
Reviewer #4 agreed
On 01 May, 2021
Reviewer #2 agreed
On 30 Apr, 2021
Reviewer #3 agreed
On 30 Apr, 2021
Editor invited
On 30 Apr, 2021
Review #1 received
Received 30 Apr, 2021
Reviews received
Received 30 Apr, 2021
Reviewers invited
Invitations sent on 30 Apr, 2021
Reviewer #1 agreed
On 30 Apr, 2021
Editor assigned
On 26 Apr, 2021
Submission checks complete
On 26 Apr, 2021
First submitted
On 19 Apr, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at Cancer Cell International.
Background
To date, no study has investigated the association of the WNT1 inducible signaling pathway protein-1 (WISP1) polymorphisms with susceptibility to gastric cancer. Therefore, we conducted this study to explore their relation.
Methods
204 gastric cancer patients and 227 normal controls were enrolled. The WISP1 SNPs rs2929973, rs7843546 and rs10956697 were selected, and their genotypic distributions were determined through PCR-RFLP
Results
In overall, we could not identify a significant association between WISP1 SNP rs2929973, rs7843546 and rs10956697) and gastric cancer risk. However, subgroup analysis demonstrated that the presence of the rs7843546 T allele was associated with a significantly decreased risk of gastric cancer in Han Chinese ethnicity (CT vs. CC: OR= 0.33, 95%CI = 0.14-0.78; TT vs. CC: OR = 0.29, 95%CI = 0.11-0.76; dominant model CT+TT vs. CC: OR = 0.32, 95%CI = 0.14-0.74). In addition, patients with the rs7843546 TT genotype were around one-third as 0.34 likely (OR = 0.34; 95% CI: 0.14-0.84) than those with the CC genotype to develop stage I/II gastric cancer. Furthermore, individuals ≥50 years old who carried the rs10956697 AC genotype represented significantly decreased risk for gastric cancer (AC vs. CC: OR = 0.58, 95%CI = 0.35-0.98). Smokers with the rs10956697 AC and AC+AA genotype were around one-third likely to develop gastric cancer (OR = 0.28, 95% CI= 0.09-0.82 and OR = 0.32, 95% CI = 0.12-0.89, respectively)
Conclusions
WISP1 SNPs rs7843546 and rs10956697 polymorphisms were the first time discovered to reduce the susceptibility to gastric cancer in different subgroup in Guangxi Chinese.
This is a list of supplementary files associated with this preprint. Click to download.
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