Cesium, strontium, and iodine radionuclides are produced from uranium fission and easily soluble in water through accidents or leakages, as those occurred at Chernobyl, Three Mile Island, and Fukushima. Thus, developing an economical and effective process for removing these radioisotopes from real water is a progressively important issue. Hence, adsorption of 137Cs, 85Sr, and 131I radionuclides was achieved using solid waste adsorbent. The solid waste adsorbent is granular activated carbon (GAC) gained from the wasted household water filters (from the second stage). After the adsorption process, the gained data illustrated that the percentages of uptake for 137Cs, 85Sr, and 131I were 87.6, 85.6, and 82.7 %, respectively. Application of GAC for the decontamination of real water as groundwater, river water, tap water, and seawater was achieved. The findings revealed that GAC has the ability to be employed effectively as a hopeful material for the decontamination of radioactive 137Cs, 85Sr, and 131I from the environmental water.