This preprint is under consideration at Italian Journal of Pediatrics. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
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Research
Elisabetta Straface
Istituto Superiore Di Sanita
Corresponding Author
ORCiD: https://orcid.org/0000-0003-0784-9077
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Since December 2019 coronavirus disease (COVID-19) emerged in Wuhan and spread rapidly worldwide. Despite the high number of people affected, data on clinical features and prognostic factors in children and adolescents are limited. We propose a retrospective study aimed to evaluate clinical characteristics of children infected with SARS-CoV-2 in Italy.
Methods: A pediatric population admitted with COVID-19 to Bambino Gesù Children's Hospital of Rome (Italy) in the period from the end of February to May 2020 has been studied taking into account gender. Medical history, comorbidities, symptoms and laboratory findings were obtained from patients' electronic medical records.
Results: In 41 patients (21 males and 20 females) we found that: i) fever and cough were the dominant symptoms, while gastrointestinal symptoms were rare; and ii) all ages of childhood were susceptible to COVID-19. Moreover, we found that females with COVID-19, were significantly
(p = 0.04) older than males and required more days of hospitalization (p = 0.01).
Moreover, compared to females, a greater number of males had high values of C reactive protein (3 males vs 1 female) and erythrocyte sedimentation rate (2 males vs 1 female).
Conclusions: Compared to the adults we found that COVID-19 infection in children is a non-severe inflammatory disease in both males and females. In any case, many detailed studies should be conducted.
Keywords
sex differences, COVID-19, inflammation, thrombocytosis, pediatric population
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CURRENT STATUS: Under Review
Version (no preprint)
Posted 16 Feb, 2021
Editorial decision: Major revision
On 16 Feb, 2021
Reviewer #2 agreed
On 16 Feb, 2021
Review #2 received
Received 16 Feb, 2021
Review #1 received
Received 11 Feb, 2021
Editor assigned
On 10 Feb, 2021
Reviewers invited
Invitations sent on 10 Feb, 2021
Reviewer #1 agreed
On 10 Feb, 2021
Submission checks complete
On 10 Feb, 2021
Editor invited
On 10 Feb, 2021
This version was not preprinted
Version 3
Posted 13 Jan, 2021
No community comments so far
Editorial decision: Major revision
On 04 Jan, 2021
Reviewer #2 agreed
On 03 Jan, 2021
Reviewers invited
Invitations sent on 03 Jan, 2021
Reviewer #1 agreed
On 03 Jan, 2021
Review #1 received
Received 03 Jan, 2021
Review #2 received
Received 03 Jan, 2021
Editor assigned
On 01 Jan, 2021
Submission checks complete
On 01 Jan, 2021
Editor invited
On 01 Jan, 2021
No comments provided
Editorial decision: Major revision
On 18 Nov, 2020
Review #1 received
Received 17 Nov, 2020
Reviewer #2 agreed
On 11 Nov, 2020
Review #2 received
Received 11 Nov, 2020
Editor assigned
On 10 Nov, 2020
Reviewers invited
Invitations sent on 10 Nov, 2020
Reviewer #1 agreed
On 10 Nov, 2020
Submission checks complete
On 10 Nov, 2020
Editor invited
On 10 Nov, 2020
No comments provided
Editorial decision: Major revision
On 30 Sep, 2020
Review #3 received
Received 17 Sep, 2020
Reviewer #4 agreed
On 14 Sep, 2020
Review #2 received
Received 13 Sep, 2020
Reviewer #2 agreed
On 10 Sep, 2020
Reviewer #3 agreed
On 10 Sep, 2020
Review #1 received
Received 30 Jul, 2020
Reviewer #1 agreed
On 21 Jul, 2020
Reviewers invited
Invitations sent on 20 Jul, 2020
Editor assigned
On 16 Jul, 2020
First submitted
On 15 Jul, 2020
Submission checks complete
On 15 Jul, 2020
Editor invited
On 15 Jul, 2020
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This preprint is under consideration at Italian Journal of Pediatrics. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research
Elisabetta Straface
Istituto Superiore Di Sanita
Corresponding Author
ORCiD: https://orcid.org/0000-0003-0784-9077
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version (no preprint)
Posted 16 Feb, 2021
Editorial decision: Major revision
On 16 Feb, 2021
Reviewer #2 agreed
On 16 Feb, 2021
Review #2 received
Received 16 Feb, 2021
Review #1 received
Received 11 Feb, 2021
Editor assigned
On 10 Feb, 2021
Reviewers invited
Invitations sent on 10 Feb, 2021
Reviewer #1 agreed
On 10 Feb, 2021
Submission checks complete
On 10 Feb, 2021
Editor invited
On 10 Feb, 2021
This version was not preprinted
Version 3
Posted 13 Jan, 2021
No community comments so far
Editorial decision: Major revision
On 04 Jan, 2021
Reviewer #2 agreed
On 03 Jan, 2021
Reviewers invited
Invitations sent on 03 Jan, 2021
Reviewer #1 agreed
On 03 Jan, 2021
Review #1 received
Received 03 Jan, 2021
Review #2 received
Received 03 Jan, 2021
Editor assigned
On 01 Jan, 2021
Submission checks complete
On 01 Jan, 2021
Editor invited
On 01 Jan, 2021
No comments provided
Editorial decision: Major revision
On 18 Nov, 2020
Review #1 received
Received 17 Nov, 2020
Reviewer #2 agreed
On 11 Nov, 2020
Review #2 received
Received 11 Nov, 2020
Editor assigned
On 10 Nov, 2020
Reviewers invited
Invitations sent on 10 Nov, 2020
Reviewer #1 agreed
On 10 Nov, 2020
Submission checks complete
On 10 Nov, 2020
Editor invited
On 10 Nov, 2020
No comments provided
Editorial decision: Major revision
On 30 Sep, 2020
Review #3 received
Received 17 Sep, 2020
Reviewer #4 agreed
On 14 Sep, 2020
Review #2 received
Received 13 Sep, 2020
Reviewer #2 agreed
On 10 Sep, 2020
Reviewer #3 agreed
On 10 Sep, 2020
Review #1 received
Received 30 Jul, 2020
Reviewer #1 agreed
On 21 Jul, 2020
Reviewers invited
Invitations sent on 20 Jul, 2020
Editor assigned
On 16 Jul, 2020
First submitted
On 15 Jul, 2020
Submission checks complete
On 15 Jul, 2020
Editor invited
On 15 Jul, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Since December 2019 coronavirus disease (COVID-19) emerged in Wuhan and spread rapidly worldwide. Despite the high number of people affected, data on clinical features and prognostic factors in children and adolescents are limited. We propose a retrospective study aimed to evaluate clinical characteristics of children infected with SARS-CoV-2 in Italy.
Methods: A pediatric population admitted with COVID-19 to Bambino Gesù Children's Hospital of Rome (Italy) in the period from the end of February to May 2020 has been studied taking into account gender. Medical history, comorbidities, symptoms and laboratory findings were obtained from patients' electronic medical records.
Results: In 41 patients (21 males and 20 females) we found that: i) fever and cough were the dominant symptoms, while gastrointestinal symptoms were rare; and ii) all ages of childhood were susceptible to COVID-19. Moreover, we found that females with COVID-19, were significantly
(p = 0.04) older than males and required more days of hospitalization (p = 0.01).
Moreover, compared to females, a greater number of males had high values of C reactive protein (3 males vs 1 female) and erythrocyte sedimentation rate (2 males vs 1 female).
Conclusions: Compared to the adults we found that COVID-19 infection in children is a non-severe inflammatory disease in both males and females. In any case, many detailed studies should be conducted.
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