Optical skyrmions are an emerging class of structured light with sophisticated particle-like topologies with great potential for revolutionizing modern informatics. However, the current generation of optical skyrmions involves complex or bulky systems, hindering the development of practical applications. Here, exploiting the emergent “lab-on-fiber” technology, we demonstrate the design of a metafiber-integrated photonic skyrmion generator. We not only successfully generated high-quality optical skyrmions from metafibers, but also experimentally verified their remarkable properties, such as topology switchable and topological stability with subwavelength features beyond the diffraction limits. Our flexible and fiber-integrated optical skyrmions platform paves the avenue for future applications of topologically-enhanced remote super-resolution microscopy and super-robust information transfer.