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Research article
Shaoshan Tang
Corresponding Author
ORCiD: https://orcid.org/0000-0003-1376-3712
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background:
To summarize the characteristics of solitary necrotic nodules (SNN) in the liver observed under contrast-enhanced ultrasonography (CEUS), and to improve the differential diagnoses value of CEUS on liver focal lesions.
Methods:
Conventional ultrasonography (US) and CEUS were performed in 24 patients who were confirmed to have SNN by pathological assessment. The US data and dynamic enhancement patterns of CEUS were recorded and retrospectively analyzed.
Results:
All patients underwent CEUS, and of these, 10 patients underwent surgical resection, while 14 patients underwent a puncture biopsy to confirm SNN. Among the 24 patients, 13 patients had a single lesion and 11 patients had multiple lesions. Eleven patients presented no enhancement in all three phases, while the other 13 patients presented with a peripheral thin rim-like enhancement in the arterial phase, an iso-enhancement in the portal phase and delayed phase, and no enhancement in the interior of the lesions.
Conclusions:
SNN has characteristic findings on the CEUS, which play an important role in the differential diagnoses of liver focal lesions.
Keywords
solitary necrotic nodules of liver; ultrasonography; contrast agent; diagnosis; differentiation
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CURRENT STATUS: Published
View the published article at BMC Gastroenterology.
No community comments so far
Submission checks complete
On 15 Jan, 2021
Editorial decision: Accept
On 10 Jan, 2021
No comments provided
Review #2 received
Received 10 Nov, 2020
Review #1 received
Received 08 Nov, 2020
Reviewer #2 agreed
On 22 Oct, 2020
Reviewer #1 agreed
On 20 Oct, 2020
Reviewers invited
Invitations sent on 19 Oct, 2020
Editor assigned
On 12 Oct, 2020
Submission checks complete
On 11 Oct, 2020
Editor invited
On 11 Oct, 2020
Version 1
Posted 20 Jul, 2020
No comments provided
Review #2 received
Received 29 Sep, 2020
Editorial decision: Major revision
On 29 Sep, 2020
Reviewer #2 agreed
On 11 Sep, 2020
Review #1 received
Received 28 Aug, 2020
Reviewers invited
Invitations sent on 30 Jul, 2020
Reviewer #1 agreed
On 30 Jul, 2020
Editor assigned
On 12 Jul, 2020
Submission checks complete
On 11 Jul, 2020
Editor invited
On 11 Jul, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Gastroenterology & Hepatology
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A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
See the published version of this preprint at BMC Gastroenterology.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Shaoshan Tang
Corresponding Author
ORCiD: https://orcid.org/0000-0003-1376-3712
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Gastroenterology.
No community comments so far
Submission checks complete
On 15 Jan, 2021
Editorial decision: Accept
On 10 Jan, 2021
No comments provided
Review #2 received
Received 10 Nov, 2020
Review #1 received
Received 08 Nov, 2020
Reviewer #2 agreed
On 22 Oct, 2020
Reviewer #1 agreed
On 20 Oct, 2020
Reviewers invited
Invitations sent on 19 Oct, 2020
Editor assigned
On 12 Oct, 2020
Submission checks complete
On 11 Oct, 2020
Editor invited
On 11 Oct, 2020
Version 1
Posted 20 Jul, 2020
No comments provided
Review #2 received
Received 29 Sep, 2020
Editorial decision: Major revision
On 29 Sep, 2020
Reviewer #2 agreed
On 11 Sep, 2020
Review #1 received
Received 28 Aug, 2020
Reviewers invited
Invitations sent on 30 Jul, 2020
Reviewer #1 agreed
On 30 Jul, 2020
Editor assigned
On 12 Jul, 2020
Submission checks complete
On 11 Jul, 2020
Editor invited
On 11 Jul, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Gastroenterology & Hepatology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Gastroenterology.
Background:
To summarize the characteristics of solitary necrotic nodules (SNN) in the liver observed under contrast-enhanced ultrasonography (CEUS), and to improve the differential diagnoses value of CEUS on liver focal lesions.
Methods:
Conventional ultrasonography (US) and CEUS were performed in 24 patients who were confirmed to have SNN by pathological assessment. The US data and dynamic enhancement patterns of CEUS were recorded and retrospectively analyzed.
Results:
All patients underwent CEUS, and of these, 10 patients underwent surgical resection, while 14 patients underwent a puncture biopsy to confirm SNN. Among the 24 patients, 13 patients had a single lesion and 11 patients had multiple lesions. Eleven patients presented no enhancement in all three phases, while the other 13 patients presented with a peripheral thin rim-like enhancement in the arterial phase, an iso-enhancement in the portal phase and delayed phase, and no enhancement in the interior of the lesions.
Conclusions:
SNN has characteristic findings on the CEUS, which play an important role in the differential diagnoses of liver focal lesions.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
Figure 9
Figure 10
Figure 11
Figure 12
Figure 13
Figure 14
Figure 15
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