See the published version of this preprint at BMC Medical Imaging.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
Research article
Zhaojun Li
Shanghai General Hospital, Shanghai Jiaotong University
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background Arterial remodeling reflects adaptation of the vessel wall to mechanical and hemodynamic stimuli and contributes to the progression of cardiovascular and cerebrovascular diseases. Tensile stress (TS) is one of the mechanical properties of the artery wall. We sought to investigate the effects of carotid viscoelasticity on its tensile stress (TS) in different age subjects.
Methods Forty-five subjects were recruited and divided into the group1 (≥50 years old) and the group2 (<50 years old) according to the median age. The carotid arteries were examined by ultrasonography, including shear wave elastography (SWE), shear wave dispersion (SWD) and radiofrequency (RF) technologies. The values were obtained, including the carotid elastic modulus (SWE R ) and viscous index (SWD R ), as well as the peak and mean TS of the left and right carotid arteries (L-PTS, R-PTS, L-MTS and R-MTS). The correlations between SWE R , SWD R and tensile stress were investigated, respectively.
Results In the group1, the carotid arteries had lower SWE R and SWD R than those in the group2 (SWE R , [10.29±9.57] kPa vs. [17.24±14.07] kPa; SWD R [11.99±3.51] (m/s)/kHz vs. [13.97±3.71] (m/s)/kHz, all P values < 0.05). In addition, the R-PTS was also lower in the group 1 ( P <0.05). Pearson correlation analysis showed that the carotid SWE R was positively correlated with tensile stress. R -values for R-PTS, R-MTS, L-PTS and L-MTS were r =0.218, r =0.359, r =0.209 and r =0.369, respectively (all P <0.05). However, the carotid SWD R was not significantly associated with TS.
Conclusion Ultrasonic shear wave imaging could be used to quantitatively assess carotid viscoelasticity. The carotid TS was related to its elasticity while little related to its viscosity, suggesting that mechanical properties of the arterial wall might be better revealed.
Keywords
Shear wave dispersion, shear wave elastography, Tensile stress, Carotid artery, Viscoelasticity, Ultrasonography
Figure 1
Figure 2
Figure 3
Loading...
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Medical Imaging.
No community comments so far
Submission checks complete
On 09 Nov, 2019
Editorial decision: Accept
On 08 Nov, 2019
No comments provided
Editorial decision: Minor revision
On 25 Oct, 2019
Editor assigned
On 08 Oct, 2019
Submission checks complete
On 07 Oct, 2019
Editor invited
On 07 Oct, 2019
Version 1
Posted 29 Aug, 2019
No comments provided
Editorial decision: Major revision
On 21 Sep, 2019
Review #1 received
Received 13 Sep, 2019
Review #3 received
Received 07 Sep, 2019
Review #2 received
Received 07 Sep, 2019
Reviewer #4 agreed
On 31 Aug, 2019
Reviewer #3 agreed
On 31 Aug, 2019
Reviewer #2 agreed
On 28 Aug, 2019
Reviewers invited
Invitations sent on 27 Aug, 2019
Reviewer #1 agreed
On 27 Aug, 2019
Submission checks complete
On 27 Aug, 2019
Editor invited
On 27 Aug, 2019
Editor assigned
On 27 Aug, 2019
First submitted
On 23 Aug, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Nuclear Medicine & Medical Imaging
Learn more about our company.
A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
See the published version of this preprint at BMC Medical Imaging.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Zhaojun Li
Shanghai General Hospital, Shanghai Jiaotong University
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Medical Imaging.
No community comments so far
Submission checks complete
On 09 Nov, 2019
Editorial decision: Accept
On 08 Nov, 2019
No comments provided
Editorial decision: Minor revision
On 25 Oct, 2019
Editor assigned
On 08 Oct, 2019
Submission checks complete
On 07 Oct, 2019
Editor invited
On 07 Oct, 2019
Version 1
Posted 29 Aug, 2019
No comments provided
Editorial decision: Major revision
On 21 Sep, 2019
Review #1 received
Received 13 Sep, 2019
Review #3 received
Received 07 Sep, 2019
Review #2 received
Received 07 Sep, 2019
Reviewer #4 agreed
On 31 Aug, 2019
Reviewer #3 agreed
On 31 Aug, 2019
Reviewer #2 agreed
On 28 Aug, 2019
Reviewers invited
Invitations sent on 27 Aug, 2019
Reviewer #1 agreed
On 27 Aug, 2019
Submission checks complete
On 27 Aug, 2019
Editor invited
On 27 Aug, 2019
Editor assigned
On 27 Aug, 2019
First submitted
On 23 Aug, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Nuclear Medicine & Medical Imaging
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Medical Imaging.
Background Arterial remodeling reflects adaptation of the vessel wall to mechanical and hemodynamic stimuli and contributes to the progression of cardiovascular and cerebrovascular diseases. Tensile stress (TS) is one of the mechanical properties of the artery wall. We sought to investigate the effects of carotid viscoelasticity on its tensile stress (TS) in different age subjects.
Methods Forty-five subjects were recruited and divided into the group1 (≥50 years old) and the group2 (<50 years old) according to the median age. The carotid arteries were examined by ultrasonography, including shear wave elastography (SWE), shear wave dispersion (SWD) and radiofrequency (RF) technologies. The values were obtained, including the carotid elastic modulus (SWE R ) and viscous index (SWD R ), as well as the peak and mean TS of the left and right carotid arteries (L-PTS, R-PTS, L-MTS and R-MTS). The correlations between SWE R , SWD R and tensile stress were investigated, respectively.
Results In the group1, the carotid arteries had lower SWE R and SWD R than those in the group2 (SWE R , [10.29±9.57] kPa vs. [17.24±14.07] kPa; SWD R [11.99±3.51] (m/s)/kHz vs. [13.97±3.71] (m/s)/kHz, all P values < 0.05). In addition, the R-PTS was also lower in the group 1 ( P <0.05). Pearson correlation analysis showed that the carotid SWE R was positively correlated with tensile stress. R -values for R-PTS, R-MTS, L-PTS and L-MTS were r =0.218, r =0.359, r =0.209 and r =0.369, respectively (all P <0.05). However, the carotid SWD R was not significantly associated with TS.
Conclusion Ultrasonic shear wave imaging could be used to quantitatively assess carotid viscoelasticity. The carotid TS was related to its elasticity while little related to its viscosity, suggesting that mechanical properties of the arterial wall might be better revealed.
Figure 1
Figure 2
Figure 3
Loading...