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Research Article
Mustafa Cellat
Mustafa Kemal Universitesi: Hatay Mustafa Kemal Universitesi
Corresponding Author
ORCiD: https://orcid.org/0000-0003-2559-096X
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Purpose
Asthma is an inflammatory disease that affects many people around the world, especially individuals of pediatric age. The effectiveness of tyrosol, a natural phenolic compound, was examined in the asthma model induced by ovalbumin (OVA).
Methods
For this purpose, 4 groups, each consisting of 8 rats, were formed. Serum physiological was given to the control group for 21 days. OVA was given to OVA, OVA + Dexamethasone (Dexa) and OVA + tyrosol groups intraperitoneally and by inhalation. Additionally, 0.25 mg/kg Dexa was administered to the OVA + Dexa group and 20 mg/kg tyrosol to the OVA + Tyrosol group by oral gavage. Serum, blood, BALF fluid and lung tissues of the rats were examined.
Results
it was observed that the MDA level decreased, GSH level and GPx activity increased, and there was no change in CAT activity in the tyrosol treatment groups. It was also observed that NF-κB, TNF-α, IL-4, IL-5, IL-13, IFN-𝛾, and IgE levels decreased compared to the OVA group. However, no effect on IL-1 β level was observed. In addition, it was determined that tyrosol treatment increased the IL-10 level. The results of the histopathological investigation of lung tissue showed that tyrosol significantly ameliorated OVA-induced histopathological lesions. Additionally, PAS staining showed that mucus hypersecretion was significantly reduced with the use of tyrosol. In addition, it was determined that the number of eosinophils decreased significantly.
Conclusions
The obtained results showed that tyrosol presented antioxidant and anti-inflammatory features on OVA-induced rats and preserved tissue architecture.
Keywords
Asthma, Tyrosol, Antioxidant, Anti-inflammatory, Anti-allergic
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CURRENT STATUS: Under Review
Version 1
Posted 30 Apr, 2021
No community comments so far
Reviews received
Received 26 Apr, 2021
Editor assigned
On 21 Apr, 2021
Reviewers invited
Invitations sent on 21 Apr, 2021
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Subject Areas
Clinical Pharmacology
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This preprint is under consideration at Naunyn-Schmiedeberg's Archives of Pharmacology. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Mustafa Cellat
Mustafa Kemal Universitesi: Hatay Mustafa Kemal Universitesi
Corresponding Author
ORCiD: https://orcid.org/0000-0003-2559-096X
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 30 Apr, 2021
No community comments so far
Reviews received
Received 26 Apr, 2021
Editor assigned
On 21 Apr, 2021
Reviewers invited
Invitations sent on 21 Apr, 2021
First submitted
On 20 Apr, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Clinical Pharmacology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Purpose
Asthma is an inflammatory disease that affects many people around the world, especially individuals of pediatric age. The effectiveness of tyrosol, a natural phenolic compound, was examined in the asthma model induced by ovalbumin (OVA).
Methods
For this purpose, 4 groups, each consisting of 8 rats, were formed. Serum physiological was given to the control group for 21 days. OVA was given to OVA, OVA + Dexamethasone (Dexa) and OVA + tyrosol groups intraperitoneally and by inhalation. Additionally, 0.25 mg/kg Dexa was administered to the OVA + Dexa group and 20 mg/kg tyrosol to the OVA + Tyrosol group by oral gavage. Serum, blood, BALF fluid and lung tissues of the rats were examined.
Results
it was observed that the MDA level decreased, GSH level and GPx activity increased, and there was no change in CAT activity in the tyrosol treatment groups. It was also observed that NF-κB, TNF-α, IL-4, IL-5, IL-13, IFN-𝛾, and IgE levels decreased compared to the OVA group. However, no effect on IL-1 β level was observed. In addition, it was determined that tyrosol treatment increased the IL-10 level. The results of the histopathological investigation of lung tissue showed that tyrosol significantly ameliorated OVA-induced histopathological lesions. Additionally, PAS staining showed that mucus hypersecretion was significantly reduced with the use of tyrosol. In addition, it was determined that the number of eosinophils decreased significantly.
Conclusions
The obtained results showed that tyrosol presented antioxidant and anti-inflammatory features on OVA-induced rats and preserved tissue architecture.
Figure 1
Figure 2
Figure 3
Figure 4
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