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Research article
Kuanrong Li
Guangzhou Women and Children's Medical Center
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Coronavirus disease 2019 (COVID-19) share similar symptoms with influenza A (IA), but it is more worthwhile to understand the disparities of the two infections regarding their clinical characteristics on admission.
Methods: A total of 71 age-matched pediatric IA and COVID-19 patient pairs were formed and their clinical data on admission were compared.
Results: Fever, cough, nasal congestion and nausea/vomiting were the most common symptoms on admission for both infections but occurred less often in COVID-19. The IA patients were more likely to have lower-than-normal levels of lymphocyte count and percentage and to have higher-than-normal levels of activated partial thromboplastin time, prothrombin time, serum C-reactive protein, and serum procalcitonin, while the COVID-19 patients had higher odds of having lower-than-normal levels of neutrophil count and percentage.
Conclusions: This study suggests that influenza A is more symptomatic than COVID-19 for children and might be an overall more severe infection at the time of admission.
Keywords
Coronavirus disease 2019, influenza A, pediatrics, retrospective study
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CURRENT STATUS: Published
View the published article at BMC Infectious Diseases.
No community comments so far
Review #1 received
Received 03 Jan, 2021
Review #2 received
Received 03 Jan, 2021
Reviewer #2 agreed
On 14 Dec, 2020
Reviewer #1 agreed
On 14 Dec, 2020
Reviewers invited
Invitations sent on 13 Dec, 2020
Editor assigned
On 24 Nov, 2020
Submission checks complete
On 24 Nov, 2020
Editor invited
On 24 Nov, 2020
Version 1
Posted 10 Aug, 2020
No comments provided
Editorial decision: Minor revision
On 17 Nov, 2020
Review #2 received
Received 07 Nov, 2020
Review #1 received
Received 29 Oct, 2020
Reviewer #3 agreed
On 25 Oct, 2020
Reviewer #2 agreed
On 21 Oct, 2020
Reviewer #1 agreed
On 08 Oct, 2020
Reviewers invited
Invitations sent on 17 Aug, 2020
Editor assigned
On 20 Jul, 2020
Submission checks complete
On 19 Jul, 2020
Editor invited
On 19 Jul, 2020
First submitted
On 17 Jul, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
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A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
See the published version of this preprint at BMC Infectious Diseases.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Kuanrong Li
Guangzhou Women and Children's Medical Center
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Infectious Diseases.
No community comments so far
Review #1 received
Received 03 Jan, 2021
Review #2 received
Received 03 Jan, 2021
Reviewer #2 agreed
On 14 Dec, 2020
Reviewer #1 agreed
On 14 Dec, 2020
Reviewers invited
Invitations sent on 13 Dec, 2020
Editor assigned
On 24 Nov, 2020
Submission checks complete
On 24 Nov, 2020
Editor invited
On 24 Nov, 2020
Version 1
Posted 10 Aug, 2020
No comments provided
Editorial decision: Minor revision
On 17 Nov, 2020
Review #2 received
Received 07 Nov, 2020
Review #1 received
Received 29 Oct, 2020
Reviewer #3 agreed
On 25 Oct, 2020
Reviewer #2 agreed
On 21 Oct, 2020
Reviewer #1 agreed
On 08 Oct, 2020
Reviewers invited
Invitations sent on 17 Aug, 2020
Editor assigned
On 20 Jul, 2020
Submission checks complete
On 19 Jul, 2020
Editor invited
On 19 Jul, 2020
First submitted
On 17 Jul, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Infectious Diseases.
Background: Coronavirus disease 2019 (COVID-19) share similar symptoms with influenza A (IA), but it is more worthwhile to understand the disparities of the two infections regarding their clinical characteristics on admission.
Methods: A total of 71 age-matched pediatric IA and COVID-19 patient pairs were formed and their clinical data on admission were compared.
Results: Fever, cough, nasal congestion and nausea/vomiting were the most common symptoms on admission for both infections but occurred less often in COVID-19. The IA patients were more likely to have lower-than-normal levels of lymphocyte count and percentage and to have higher-than-normal levels of activated partial thromboplastin time, prothrombin time, serum C-reactive protein, and serum procalcitonin, while the COVID-19 patients had higher odds of having lower-than-normal levels of neutrophil count and percentage.
Conclusions: This study suggests that influenza A is more symptomatic than COVID-19 for children and might be an overall more severe infection at the time of admission.
Figure 1
This is a list of supplementary files associated with this preprint. Click to download.
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