Potential Association Between Bacterial Infections and Ischemic Stroke Based on Fifty Case-Control Studies: A Systematic Review and Meta-Analysis

doi:10.21203/rs.3.rs-44791/v1

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Potential Association Between Bacterial Infections and Ischemic Stroke Based on Fifty Case-Control Studies: A Systematic Review and Meta-Analysis

https://doi.org/10.21203/rs.3.rs-44791/v1

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Background: Stroke is considered as one of the most concerns in health services facilities worldwide, and occurs in two types, ischemic stroke and hemorrhagic stroke. However, almost the three quarters of stroke cases are ischemic stroke which occur in effect of several risk factors such as hypertension, obesity, atherosclerosis, diabetes mellitus, arteritis, and inflammatory response. In recent years, infectious diseases are considered as one of the most important risk factors of ischemic stroke. In this regard, some bacteria causing the chronic infections in particular Chlamydia pneumonia, Helicobacter pylori, Mycoplasma pneumonia, and Mycobacterium tuberculosis get more attended.

Methods: In the present meta-analysis, we studied 50 case-control studies and evaluated potential relevance of these infections with creation and development of ischemic stroke.

Results: We surveyed the information of 33,978 participants in several nested case-control studies and demonstrated that bacterial infections can increase the risk of ischemic stroke.

Conclusions: In this meta-analysis we demonstrated a meaningful relationship between infection by three bacteria C. pneumoniae, H. pylori, and M. tuberculosis with occurrence of ischemic stroke.

Neurology

Neurosurgery

Ischemic stroke

Chlamydia pneumonia

Helicobacter pylori

Mycoplasma pneumonia

Mycobacterium tuberculosis

Meta-analysis

Bacterial infection

Nowadays stroke is accounted as one of the most striking complications of cardiovascular disorders, and is classified into the two groups, ischemic stroke and hemorrhagic stroke. The frequency of ischemic stroke is more that the hemorrhagic stroke, so that about 71% of strokes are ischemic and others are hemorrhagic (1). In general, strokes (ischemic and hemorrhagic) are known as the second most common cause of death in the world, and have affected 13.7 million worldwide (2). This disease is turn to one of the global health concerns, so that it is estimated that one out of four people would be experienced it during life (3). Several risk factors play a fundamental role in stroke occurrence which include obesity, hypertension, smoking, dyslipidemia, diabetes mellitus, alcohol consumption, atrial fibrillation, carotid stenosis, inflammation, and epigenetic events of host (4). Lately the role of inflammatory process in forming and promoting atherosclerotic plaques, carotid intima-media thickness (CIMT), arterial wall disruption, and vascular wall instability has been well documented (5). However, it is not well known the role of infectious agents as inflammatory response, but there are various documents regarding microorganisms such as Cytomegalovirus (CMV), Hepatitis C virus (HCV), Human immunodeficiency virus (HIV), Herpes simplex virus type 1–2 (HSV 1–2), Epstein Barr virus (EBV), Influenza virus, periodontal microflora, Helicobacter pylori, Chlamydia pneumoniae, Haemophilus influenza, Mycoplasma pneumoniae, Mycobacterium tuberculosis, Streptococcus pneumonia, Tannerella forsythia, and their role in formation of atherosclerotic lesions, metabolism disorders, hypertension, and promotion of cardiovascular disease (CVD) indexes (6–11). It seems that human pathogenic bacteria can be assumed as risk factors in developing CVD through mechanisms such as toxins, enzymes, influence on host immune response during chronic infections, and infective endocarditis (3, 6). According to review of the literature, endocarditis and septicemia increase the risk of infection to stroke (12); Nevertheless, information is limit in this context. The present study was done for the purpose of plausible relationship between ischemic stroke and infection by H. pylori, C. pneumoniae, M. pneumoniae, and M. tuberculosis. Also, potential risk for affecting to stroke was estimated for each group of infective agents.

2.1. Literature search strategy

The comprehensive systematic search up to May 2020 was used databases Scopus, PubMed, Cochrane Library, Embase, and Google scholar. For searching, we used keywords “Helicobacter pylori” AND “Ischemic Stroke” OR “Chlamydia pneumonia” AND “Ischemic Stroke” OR “Mycoplasma pneumonia” AND “Ischemic Stroke” OR “Mycobacterium tuberculosis” AND “Ischemic stroke” OR “Bacterial infection” AND “Ischemic stroke”. Without limitation in date of publication, all published English article were retrieved. Searching strategy was done by two authors, separately; in disagreements, the third author judged and made decision.

2.2. Study selection criteria

In the present meta-analysis inclusion criteria were contained four items: 1) case-control studies on the role of bacterial infections in developing to ischemic stroke; 2) the only included studies on the role of infection by H. pylori, C. pneumoniae, M. pneumoniae, and M. tuberculosis; 3) accordance of methods based on standard protocols including ELISA and other immunoassays, conventional microbiology methods, PCR, blotting assay, and finally urease breath test; 4) clarity in the results of studies. In addition, the studies consist of case-report, letter to editor, review, congress abstract, non-English, prospective or cohort, and also other studies such post-stroke infections, repetitive results, and unclear studies, were considered as exclusion criteria. The flowchart of included studies is presented in Fig. 1.

2.3. Quality assessment and data collection

The quality assessment of included studies was evaluated by The Newcastle-Ottawa Scale (NOS). Required information include first author, publication year, location of each studies, type of infection agents, diagnostic methods for infection, age, gender, case group, control group, and number of infected cases in both case and control groups (Table 1).

Table 1

Characteristics of included studies
First Author	Year	Area	Age (year)		Gender (F/M)		Case group (n)	Control group (n)	Microorganism type	Number of bacterial infections (n)		Method	Ref
First Author	Year	Area	case	control	case	control	Case group (n)	Control group (n)	Microorganism type	case	control	Method	Ref
Masoud	2005	Iran	64.3	61.7	43/48	40/40	91	80	H. pylori	59	36	ELISA	(13)
Srivastava	2014	India	43.6	43.2	NA	NA	80	80	C. pneumoniae	42	26	ELISA	(14)
Muller	2003	Denmark	69	45	84/109	125/243	193	368	C. pneumoniae	20	29	PCR	(15)
Jozwiak	2007	Poland	44	40	40/54	44/59	94	103	C. pneumoniae	63	15	ELISA	(16)
Kongoji	2005	Japan	63.5	62.7	7/6	2/5	13	7	C. pneumoniae	5	0	PCR	(17)
Kawamoto	2003	Japan	75	74	17/23	48/37	40	85	C. pneumoniae	29	52	ELISA	(18)
Gabrielli	2003	Italy	68	66	56/49	66/64	105	130	H. pylori	75	81	ELISA	(19)
Sagar	2016	India	47.8	46.6	14/25	8/22	39	30	H. pylori	26	12	ELISA	(20)
Majka	2002	Germany	NA	NA	NA	NA	80	80	H. pylori	69	54	ELISA	(21)
Mrđen	2017	Croatia	72.8	72.8	34/32	34/32	82	93	H. pylori	21	32	ELISA	(22)
Ashtari	2008	Iran	65.4	60.2	43/38	24/19	81	43	H. pylori	57	29	ELISA	(23)
Lin	2008	Taiwan	64.2	63.2	202/248	198/252	450	450	C. pneumoniae	334	257	ELISA	(24)
Ponzetto	2002	Italy	56.7	57.4	22/58	88/232	80	320	H. pylori	64	190	UBT	(25)
Bandaru	2008	India	47.8	47.8	149/51	149/51	200	200	C. pneumoniae	72	35	ELISA	(26)
Mousavi	2011	Iran	65.6	62.9	46/50	36/57	96	93	H. pylori	44	39	ELISA	(27)
Hassanein	2014	Egypt	53	52.6	35/55	25/35	90	60	H. pylori	70	32	ELISA	(28)
Rasura	2013	Italy	NA	NA	NA	NA	101	101	C. pneumoniae	26	8	ELISA	(29)
Eini	2014	Iran	68.9	66.9	60/81	60/81	141	141	C. pneumoniae	111	74	ELISA	(30)
Cook	2016	UK	67.9	56.5	73/103	674/844	176	1518	C. pneumoniae	81	280	MIF	(31)
Bastiani	2008	Italy	76.6	76.5	51/55	51/55	106	106	H. pylori	67	57	UBT	(32)
Elkind	2000	USA	68.5	68.5	47/42	47/42	89	89	C. pneumoniae	72	74	ELISA	(33)
Elkind	2006	USA	72.3	72.3	125/121	219/38	246	474	C. pneumoniae	156	257	ELISA	(34)
Ebrahimi-Rad	2014	Iran	NA	NA	NA	NA	27	25	C. pneumoniae	20	13	ELISA	(35)
Hasan	2011	Iraq	58.02	56.1	18/32	18/22	50	40	C. pneumoniae	36	21	ELISA	(36)
Wincup	1996	UK	54	53.5	NA	NA	137	136	H. pylori	93	78	ELISA	(37)
Park	2006	Korea	66.7	66.8	62/63	62/63	125	125	H. pylori	100	75	ELISA	(38)
Heuschmann	2016	Germany	74.6	74.6	77/68	138/122	145	260	H. pylori	67	117	ELISA	(39)
Salmasi	2017	Iran	66.7	65.9	38/32	39/31	70	70	H. pylori	61	51	ELISA	(40)
Madre	2002	Spain	70	70	46/45	53/59	91	112	C. pneumoniae	40	34	IFI	(41)
Ķēniņa	2011	Latvia	65.8	64.3	41/61	22/26	102	48	C. pneumoniae	64	17	ELISA	(42)
Moayyedi	2003	UK	70.5	70.2	228/239	227/161	467	388	H. pylori	274	206	ELISA	(43)
Ngeh	2003	UK	NA	NA	59/41	60/27	100	87	C. pneumoniae	71	57	ELISA	(44)
Roham	2016	Iran	69.1	67.2	61/36	51/46	97	97	M. pneumoniae	4	0	ELISA	(45)
Ngeh	2004	UK	80	80	59/41	57/25	100	82	M. pneumoniae	95	82	ELISA	(46)
Njamnshi	2006	Cameroon	NA	NA	64/0	64/0	64	64	C. pneumoniae	41	35	ELISA	(47)
Rai	2011	India	53.6	38.6	16/35	14/34	51	48	C. pneumoniae	32	38	ELISA	(48)
Pietroiusti	2002	Italy	63.2	63.9	11/50	89/62	61	151	H. pylori	43	106	PCR	(49)
Wu	2014	Taiwan	53	53.2	1922/3882	1925/3879	5804	5804	M. tuberculosis	176	207	Culture	(50)
Bandaru	2009	India	35.3	35.3	30/90	30/90	120	120	C.pneumoniae	35	15	ELISA	(51)
Sheu	2014	Taiwan	33.5	42.4	824/1459	2939/3910	2283	6849	M. tuberculosis	136	256	Culture	(52)
Bandaru	2012	India	74	71	30/70	32/68	100	100	C.pneumoniae	29	16	ELISA	(53)
Tanne	2003	Israel	61	61	8/126	8/126	134	134	C. pneumoniae	115	110	ELISA	(54)
Gagliardi	2009	Brazil	NA	NA	25/40	37/22	65	59	C. pneumoniae	0	1	PCR	(55)
Voorend	2004	Netherlands	43.9	39.4	22/19	31/24	41	55	C. pneumoniae	28	38	ELISA	(56)
Grau	2001	Germany	62	59.5	36/73	27/55	109	82	H. pylori	57	34	ELISA	(57)
Wohlschlaeger	2005	Germany	65.1	73.3	5/5	16/7	7	21	C. pneumoniae	4	1	PCR	(58)
Anzini	2004	Italy	34.6	36.5	60/81	90/102	141	192	C. pneumoniae	2.9 (95% CI: 1.77–4.76)		ELISA	(59)
Johnsen	2005	Denmark	60.4	60.5	99/155	99/155	254	254	C. pneumoniae	1.28 (95% CI: 0.83–1.95)		ELISA	(60)
Sawayama	2005	Japan	71.5	69	22/40	95/48	62	143	H. pylori	9.68 (95% CI: 3.56–33.08)		UBT	(61)
Tarnacka	2002	Poland	74	66	91/88	66/56	179	122	C. pneumoniae	6.00 (95% CI: 1.61–22.29)		ELISA	(62)

2.4. Quantitative synthesis

Analyzing of data was done by use of Comprehensive Meta-Analysis (CMA) software version 2.2 (Biostat, Englewood, NJ). For this purpose, first the frequency of either bacterial infection including H. pylori, C. pneumoniae, M. pneumoniae, and M. tuberculosis for both case and control groups was measured and reported according event rate (%). Next, potential role of bacterial infection in forming and developing to ischemic stroke was calculated using Odds ratio (OR) with 95% Confidence intervals (CIs). Moreover, by Cochran's Q and I² statistic parameters, we analyzed heterogeneity of included studies. Based on our default, the cases with Cochrane Q statistic p < 0.1 and I² > 25% were considered as high heterogeneity cases. According to the Dersimonian and Laird method, the random effect model and the fixed effect model were applied in high heterogeneity and low heterogeneity cases respectively. Finally, Egger’s regression was used for estimating asymmetry of funnel plot and also publication bias.

3.1. Characterization of included studies

Regarding primary searching, 238 documents of 1996–2017 was identified and finally in accordance with inclusion criteria 50 studies were selected. Of these studies, 28, 18, 2, and 2 studies were related to C. pneumoniae, H. pylori, M. pneumoniae, and M. tuberculosis respectively. In addition, the diagnostic methods were included ELISA, PCR, UBT, MIF, IFI, and conventional microbiology. In the present study the information of 33,978 individuals including 13,652 patients (case) and 20,326 healthy (control) was investigated. Average of age in case and control groups was 61.7 and 59.8 respectively. The frequency of men in both case and control groups was measured 62.6% and 56.1% respectively. According to statistical analysis, the bacterial infection in both case (ischemic stroke) and control groups was 38% (37–39 with 95% CIs) and 26% (25–27 with 95% CIs) respectively. We also found a meaningful relationship between bacterial infections and progression into the ischemic stroke (OR: 1.704; 1.57–1.84 with 95% CIs; p value = 0.01; I² = 78.55; Q-value: 219.11; df = 47; Egger’s intercept = 1.23).

3.2. The possible association between C. pneumonia infection and ischemic stroke

We found twenty articles which were about the role of infection by C. pneumonia in progression to stroke. The rate of infection was estimated in both stroke and healthy groups 57% (54–59 with 95% CIs) and 36% (34–37 with 95% CIs) respectively. A significant relevance was observed between infection by C. pneumonia and stroke (OR: 2.14; 1.91–2.38 with 95% CIs; p-value = 0.001; I² = 71; Q-value = 93.29; df = 27; Egger’s intercept = 0.06).

3.3. The possible association between H. pylori infection and ischemic stroke

Of total of fifty case-control articles which was been included to this meta-analysis, eighteen articles were about the relevance of infection by H. pylori and stroke. The infection rate in both patient and healthy groups was 63% (60–65 with 95% CIs) and 55% (52–57 with 95% CIs) respectively. In accordance with statistical results, it seems that there is a meaningful relationship between infection by H. pylori and ischemic stroke (OR: 1.64; 1.44–1.87 with 95% CIs; p value = 0.001; I2 = 72.88; Q-value = 59; df = 16; Egger’s intercept = 1.87).

3.4. The possible association between M. pneumonia infection and ischemic stroke

In relating of plausible role of infection by M. pneumonia and occurrence of ischemic stroke we found only two eligible studies. The incidence rate of infection in both case and control groups was 55% (39–70 with 95% CIs) and 47% (11–86 with 95% CIs) respectively. We did not find any significant relationship between M. pneumonia infection with ischemic stroke (OR: 0.97; 0.12–7.69 with 95% CIs; p-value = 0.98; I2 = 77.94; Q-value = 4.53; df = 1).

3.5. The possible association between M. tuberculosis infection and ischemic stroke

Finally, for evaluating the relevance between infection by M. tuberculosis and stroke we used two studies. Based on statistical analysis, the rate of infection by M. tuberculosis in both ischemic and age-gender matched healthy groups was 4% (3.6–4.5 with 95% CIs) and 3% (3.3-4 with 95% CIs) respectively. However, we observed a significant relationship between infection by M. tuberculosis and development into the ischemic stroke (OR: 1.15; 0.99–1.34 with 95% CIs; p-value = 0.05; I2 = 94.73; Q-value = 18.98; df = 1). Generally in the present study we appraised the potential role of bacterial infections by C. pneumoniae, H. pylori, M. pneumoniae, M. tuberculosis, and progression to ischemic stroke. In this meta-analysis we demonstrated a meaningful relationship between infection by three bacteria C. pneumoniae, H. pylori, and M. tuberculosis with occurrence of ischemic stroke. Nevertheless, the high heterogeneity and low validity of studies affected on our results. In addition, due to the limitation of results we could not evaluate the role of underlying factors such as age and gender.

It is clear that the stroke is one of the most highlight cardiovascular disorders, and traditional risk factors including hypertension, diabetes mellitus, smoking, hyperlipidemia, atrial fibrillation, atherosclerosis, age, male sex, and positive family history can increase the risk of it (13). Predisposing risk factors for emerging and developing of stroke are different regarding differences in individuals, so that increase of stroke in the youth and its trend to autumn and winter shows some interfering modifiable risk factors that are not well known (14). In recent decades understanding of the role of acute and chronic infections in the occurrence of stroke is interested, so that various nested case-control studies have been conducted in this regard. Obviously infection can be lead to inflammation, which in turn triggers some complications such as formation of fatty plaques in the vessel wall, atherogenic reactions, and alteration in host metabolism (15). These changes are as underlying factors for affecting on CVDs especially ischemic stroke (Fig. 2). Of all, the infections caused by pathogens such as C. pneumonia, H. pylori, M. pneumonia, HIV, HSV 1–2, and CMV are more considerable, so that these infectious microorganisms have been frequently isolated from atherosclerosis plaque (16). On the other hand, induction of CIMT and high portion of seropositive population affected by CVD confirm this phenomenon (17). Nowadays there are several documents about the role of bacterial infections in increasing of stroke; for example, infective endocarditis causes to create emboli and arteritis. Moreover, bacterial meningitis and chronic brucellosis can be caused vasculitis and thrombosis in brain arteries, and likewise, rickettsial infections lead to damage of small vascular endothelial cells and the onset of ischemic stroke (14). In recent study the impressive role of bacterial infections in increasing of ischemic stroke was demonstrated, and using statistical analysis of fifty case-control studies we showed that there is a significant relationship between bacterial infection and ischemic stroke cases (OR: 1.7; CI: 1.5–1.8). C. pneumonia is a gram negative and obligate intracellular bacterium that was first introduced in 1980s. More than half of population is infected by this bacterium worldwide, and serological investigations has confirmed this fact (18, 19). In many studies researchers has isolated C. pneumonia from carotid plaques, atherosclerotic plaques, and circulating leukocytes (15). Sander et al. (2004) showed that eradication of C. pneumonia infection can be lead to stop CIMT (20). The clinical trial studies also have shown that the treatment of this infection can be caused reduction of vascular lesions in patients (21). In our study the rate of infection by C. pneumonia in both case and control groups was evaluated 57% and 36% respectively. Also, we showed that there is a meaningful relationship between infection by this bacterium and emergence of ischemic stroke (OR: 2.14; CI: 1.9–2.3). H. pylori is a spiral, gram negative, and microaerophilic bacterium which is colonized in human gastric sub-mucosa about half of the world’s population (22). The rate of infection by this bacterium in developing countries is more than developed countries, so that in some regions of Africa infection by this pathogen reaches about 100% (23, 24). The bacterium is accounted as etiologic agent in disorders such chronic gastritis, peptic ulcer, as well as gastric cancer. However, H. pylori-related extra-gastrointestinal diseases have attracted a lot of attention, in which the relevance of H. pylori infection and CVD is well-known (25, 26). In addition to the several evidence regarding with isolation of H. pylori from atherosclerotic plaques, there are various documents about the effect of infection by this bacterium on some complications including insulin resistance, dyslipidemia, hypertension, and alteration in metabolism which describe the potential role of infection with this bacterium in increasing of ischemic stroke (27, 28). Based on our statistical analysis, the infection by this pathogen in both groups of ischemic stroke patients and age-gender matched healthy individuals was estimated 63% and 55% respectively. We observed a significant relationship between infection by this bacterium and development of ischemic stroke (OR: 1.6; CI: 1.4–1.8). M. pneumonia is one of the respiratory pathogens that in spite of poor understanding about its pathogenicity, many of people have anti-M. pneumonia antibodies (IgG and IgM). In recent several studies have noted to its role in extra-pulmonary manifestations such musculoskeletal, gastrointestinal, dermatologic, hematologic, neurological involvements, and cardiovascular complications (27, 29). According to review of the literature, near the 0.1% of infected to M. pneumonia will get neurological disability during their lives (30). The vasculopathies lesions caused as a result of this bacterial infection are indicating the role of M. pneumonia in increasing the ischemic stroke (14, 31). Two studies in this meta-analysis were related to the role of M. pneumonia in susceptibility to ischemic stroke; infection by this bacterium in both groups of case and control was 55% and 47% respectively. Also, based on statistical analysis we observed no significant relationship between infection by M. pneumonia and ischemic stroke (OR: 0.97; CI: 0.12–7.6). However, the low sample number could effect on outcomes, since only two studies allocated to this bacterium. In addition, high heterogeneity causes instability of results and we need furthermore studies in this regard. M. tuberculosis is one of the threatening pathogens of human life. Although this bacterium usually is known with the term “pulmonary tuberculosis”, but it is a facultative intracellular pathogen which also has extra-pulmonary manifestations (32). In recent years the role of bacterium in promoting of neurological manifestation has been evaluated, so that in result of arterial invasion, malignant vasculitis can be occurred during the tubercular meningitis (14).

In the present study the information of two nested case-control studies about the role of M. tuberculosis in ischemic stroke was appraised. The rate of infection by this pathogen in both groups of case and control was 4% and 3% respectively; we found a significant relevance between mycobacterial infection and ischemic stroke (OR: 1.1; CI: 0.99–1.34). In this study we assessed the relationship between bacterial infections and development of ischemic stroke. Nevertheless, due to limitation of in results we could not evaluate the role existing factors such age and sex in our research. Overall, for understanding the role of bacterial infections in ischemic stroke, it is better to do more studies about the association between bacterial infections and traditional ischemic stroke risk factors, carotid intima-media thickness, atherosclerosis, and cardiovascular risk factor such as LDL and HDL. Another limitation of our studies were including low sample number, excessive heterogeneity, potential publication bias, and low sturdy number in particular M. pneumonia and M. tuberculosis. We recommend further studies with more sample volume for determining the bacterial infection and their determinative role in ischemic stroke.

Carotid intima-media thickness

CIMT

Cardiovascular disease

CVD

Cytomegalovirus

CMV

Hepatitis C virus

HCV

Human immunodeficiency virus

HIV

Herpes simplex virus type 1–2

HSV 1–2

Epstein Barr virus

EBV

- Ethics approval and consent to participate

Not applicable (this paper was provided based on researching in global databases)

- Consent to publish

All authors have informed consent about the content of this paper.

- Availability of data and materials

All data will be available for anyone who requests those.

- Competing interests

There is no any conflict of interest among the all authors.

- Funding

We have not received any funding for this research.

- Authors' Contributions

MK was a major contributor in writing the manuscript
MK was research director and translated this manuscript to English

All authors read and approved the final manuscript

- Acknowledgements

We appreciate from both Mashhad University of Medical Sciences and Jiroft University of Medical Sciences.

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published 01 Apr, 2022

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Potential Association Between Bacterial Infections and Ischemic Stroke Based on Fifty Case-Control Studies: A Systematic Review and Meta-Analysis

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Abstract

Figures

1. Background

2. Methods

2.2. Study selection criteria

2.3. Quality assessment and data collection

2.4. Quantitative synthesis

3. Results

3.1. Characterization of included studies

3.2. The possible association between C. pneumonia infection and ischemic stroke

3.3. The possible association between H. pylori infection and ischemic stroke

3.4. The possible association between M. pneumonia infection and ischemic stroke

3.5. The possible association between M. tuberculosis infection and ischemic stroke

4. Discussion

5. Conclusion

6. Abbreviations

7. Declarations

8. References

Supplementary Files

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