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Research article
Fariborz Moazami
Department of Endodontics, Dental School, Shiraz University of Medical Sciences, Shiraz, Iran
Corresponding Author
ORCiD: https://orcid.org/0000-0002-3035-2926
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
The aim of this study is to evaluate the ability of sodium thiosulfate (STS) to reverse the adverse effect of sodium hypochlorite (NaOCl) on dentin microhardness.
Methods
Fifty single-rooted teeth were decoronated and longitudinally sectioned. The samples were divided into a control and four sample groups (n = 20): Normal saline for 15 min as the control group, G1: 2.5% NaOCl for 15 min without an incubation period, G2: 2.5% NaOCl for 15 min, G3: 2.5% NaOCl for 15 min irrigated with normal saline followed by 5% Na2S2O3 for 10 min, G4: Normal saline for 15 min followed by 5% Na2S2O3 for 10 min. All groups except G1 were incubated for 1 week. The microhardness measurements were determined using the Vickers micro-hardness test. Data were analyzed using the Kruskal-Wallis test for pairwise comparisons. A p-value < 0.05 was considered significant.
Results
All groups showed a significant decrease in the micro-hardness value compared with the control group. NaOCl for 1 week (G2) reduced the micro-hardness of dentine compared with samples, tested immediately after immersion in NaOCl (G1) (p < 0.05). NaOCl alone (G2) or treated with Na2S2O3 (G3) resulted in a significant decrease in microhardness compared with the Na2S2O3 group (G4) (p < 0.05).
Conclusions
Sodium thiosulfate as a neutralizing agent could not prevent the microhardness downturn caused by sodium hypochlorite
Keywords
dentin,microhardness tests, sodium hypochlorite, sodium thiosulfate
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CURRENT STATUS: Published
View the published article at BMC Oral Health.
No community comments so far
Submission checks complete
On 09 Nov, 2020
Editorial decision: Accept
On 05 Nov, 2020
No comments provided
Editorial decision: Minor revision
On 28 Oct, 2020
Editor assigned
On 26 Oct, 2020
Submission checks complete
On 25 Oct, 2020
Editor invited
On 25 Oct, 2020
Version (no preprint)
Posted 05 Aug, 2020
Editorial decision: Major revision
On 21 Oct, 2020
Editor assigned
On 20 Oct, 2020
Submission checks complete
On 19 Oct, 2020
Editor invited
On 19 Oct, 2020
This version was not preprinted
Version 1
Posted 04 Aug, 2020
No comments provided
Editorial decision: Major revision
On 15 Sep, 2020
Review #1 received
Received 07 Sep, 2020
Review #2 received
Received 04 Sep, 2020
Reviewer #2 agreed
On 30 Aug, 2020
Reviewer #1 agreed
On 19 Aug, 2020
Reviewers invited
Invitations sent on 03 Aug, 2020
Editor assigned
On 24 Jul, 2020
First submitted
On 23 Jul, 2020
Submission checks complete
On 23 Jul, 2020
Editor invited
On 23 Jul, 2020
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A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
See the published version of this preprint at BMC Oral Health.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Fariborz Moazami
Department of Endodontics, Dental School, Shiraz University of Medical Sciences, Shiraz, Iran
Corresponding Author
ORCiD: https://orcid.org/0000-0002-3035-2926
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Oral Health.
No community comments so far
Submission checks complete
On 09 Nov, 2020
Editorial decision: Accept
On 05 Nov, 2020
No comments provided
Editorial decision: Minor revision
On 28 Oct, 2020
Editor assigned
On 26 Oct, 2020
Submission checks complete
On 25 Oct, 2020
Editor invited
On 25 Oct, 2020
Version (no preprint)
Posted 05 Aug, 2020
Editorial decision: Major revision
On 21 Oct, 2020
Editor assigned
On 20 Oct, 2020
Submission checks complete
On 19 Oct, 2020
Editor invited
On 19 Oct, 2020
This version was not preprinted
Version 1
Posted 04 Aug, 2020
No comments provided
Editorial decision: Major revision
On 15 Sep, 2020
Review #1 received
Received 07 Sep, 2020
Review #2 received
Received 04 Sep, 2020
Reviewer #2 agreed
On 30 Aug, 2020
Reviewer #1 agreed
On 19 Aug, 2020
Reviewers invited
Invitations sent on 03 Aug, 2020
Editor assigned
On 24 Jul, 2020
First submitted
On 23 Jul, 2020
Submission checks complete
On 23 Jul, 2020
Editor invited
On 23 Jul, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Oral Health.
Background
The aim of this study is to evaluate the ability of sodium thiosulfate (STS) to reverse the adverse effect of sodium hypochlorite (NaOCl) on dentin microhardness.
Methods
Fifty single-rooted teeth were decoronated and longitudinally sectioned. The samples were divided into a control and four sample groups (n = 20): Normal saline for 15 min as the control group, G1: 2.5% NaOCl for 15 min without an incubation period, G2: 2.5% NaOCl for 15 min, G3: 2.5% NaOCl for 15 min irrigated with normal saline followed by 5% Na2S2O3 for 10 min, G4: Normal saline for 15 min followed by 5% Na2S2O3 for 10 min. All groups except G1 were incubated for 1 week. The microhardness measurements were determined using the Vickers micro-hardness test. Data were analyzed using the Kruskal-Wallis test for pairwise comparisons. A p-value < 0.05 was considered significant.
Results
All groups showed a significant decrease in the micro-hardness value compared with the control group. NaOCl for 1 week (G2) reduced the micro-hardness of dentine compared with samples, tested immediately after immersion in NaOCl (G1) (p < 0.05). NaOCl alone (G2) or treated with Na2S2O3 (G3) resulted in a significant decrease in microhardness compared with the Na2S2O3 group (G4) (p < 0.05).
Conclusions
Sodium thiosulfate as a neutralizing agent could not prevent the microhardness downturn caused by sodium hypochlorite
Figure 1
Figure 2
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