The Yellow River interlayer filling reclamation technology can effectively improve the quality of destroyed cultivated land in the condition of limited soil resources. However, it is a conundrum to choose the appropriate sandwich strategy according to the amount of soil that can be backfilled. This study using the Hydrus-1D model to simulate water movement in reclaimed multiple-layered soils were to understand the mechanism of interlayer, and predict the optimal profile for reclaimed with Yellow River sediments. Simulations were performed on 18 soil profiles that were divided into a control check (CK) and two general scenarios that the total thickness of soil were 50 and 60 cm. Treatments in both scenarios exhibited interaction of different positions and thicknesses of soil interlayer. Results showed that removing part of the subsoil overlying the sediment placed it between sediment layers will improve the infiltration character of the conventional reconstructed soil profiles (T50-0 and T60-0). Moreover, changing the thickness of the interlayers affected infiltration character and soil water-holding capacity more than changes in the position of the layers for same total thickness of native soil. The optimal reconstructed soil profiles for scenarios 1 and 2 were T50-6 (interlayer thickness of 20 cm and located at a position of 30 cm) and T60-9 (interlayer thickness of 30 cm and located at a position of 30 cm), which could have a better infiltration character that were more closed to the native farmland.