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Research Article
Guangbin Cui
Air Force Medical University Tangdu Hospital
Corresponding Author
Yi Zhang
Xidian University
Corresponding Author
ORCiD: https://orcid.org/0000-0003-0859-9735
Yongzhan Nie
Air Force Medical University Xijing Hospital: Xijing Hospital
Corresponding Author
License:
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Patients with functional constipation (FCon) have been reported with brain functional abnormalities. The associations between constipation symptoms and brain functional connectivity (FC) in these patients are not well understood. Here we used functional magnetic resonance imaging (MRI) to examine FC alterations between resting-state networks (RSNs) and their associations with constipation symptoms in patients with FCon. The investigation of these characteristics might help to reveal the underlying neural mechanisms. Functional MRI with independent component analysis was applied to investigate alterations in FC within and functional network connectivity (FNC) between RSNs including default mode- (DMN), basal ganglia- (BGN), salience- (SN), left and right control executive-network (LCEN/ RCEN) in 39 female patients with FCon and 36 female healthy controls (HC). Patient Assessment of Constipation Quality of Life Scale (PAC-QOL) and Patient Assessment of Constipation Symptom Scale (PAC-SYM) were used to assess the constipation symptoms. Results showed that FCon patients had changed regional FC between different networks contributed to the abnormal FNCs among RSNs compared with HC. Patients with greater stool syndromes had increased FNC of BGN-SN and DMN-LCEN, and patients with greater worries/concerns and PAC-QOL total score had reduced FNC of SN-RCEN. The greater strength changes of FC in prefrontal and in parietal cortices were associated with higher negative emotion scores and greater rectal symptoms respectively. Our functional MRI suggested that FCon patients had altered FC within and interaction between RSNs and the brain FC changes were associated with constipation symptoms and altered emotions.
Keywords
functional constipation, functional connectivity, independent component analysis, resting-state fMRI, resting-state network
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This preprint is under consideration at Brain Imaging and Behavior. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Guangbin Cui
Air Force Medical University Tangdu Hospital
Corresponding Author
Yi Zhang
Xidian University
Corresponding Author
ORCiD: https://orcid.org/0000-0003-0859-9735
Yongzhan Nie
Air Force Medical University Xijing Hospital: Xijing Hospital
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 05 May, 2021
No community comments so far
Reviews received
Received 03 May, 2021
Reviewers invited
Invitations sent on 03 May, 2021
First submitted
On 21 Apr, 2021
Editor assigned
On 21 Apr, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Patients with functional constipation (FCon) have been reported with brain functional abnormalities. The associations between constipation symptoms and brain functional connectivity (FC) in these patients are not well understood. Here we used functional magnetic resonance imaging (MRI) to examine FC alterations between resting-state networks (RSNs) and their associations with constipation symptoms in patients with FCon. The investigation of these characteristics might help to reveal the underlying neural mechanisms. Functional MRI with independent component analysis was applied to investigate alterations in FC within and functional network connectivity (FNC) between RSNs including default mode- (DMN), basal ganglia- (BGN), salience- (SN), left and right control executive-network (LCEN/ RCEN) in 39 female patients with FCon and 36 female healthy controls (HC). Patient Assessment of Constipation Quality of Life Scale (PAC-QOL) and Patient Assessment of Constipation Symptom Scale (PAC-SYM) were used to assess the constipation symptoms. Results showed that FCon patients had changed regional FC between different networks contributed to the abnormal FNCs among RSNs compared with HC. Patients with greater stool syndromes had increased FNC of BGN-SN and DMN-LCEN, and patients with greater worries/concerns and PAC-QOL total score had reduced FNC of SN-RCEN. The greater strength changes of FC in prefrontal and in parietal cortices were associated with higher negative emotion scores and greater rectal symptoms respectively. Our functional MRI suggested that FCon patients had altered FC within and interaction between RSNs and the brain FC changes were associated with constipation symptoms and altered emotions.
Figure 1
Figure 2
Figure 3
Figure 4
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