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Research Article
cai kebo
shanghai jiaotong unniversity
Corresponding Author
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This work is licensed under a CC BY 4.0 License. Read Full License
Purpose To explore changes of Eotaxin-1concentration in tears of thyroid associated
ophthalmopathy (TAO) patients
Methods This prospective observational study.16 patients with TAO (32 eyes) and 18
healthy volunteers (36 eyes) were recruited.TAO patients were divided into active TAO (16eyes) and inactive TAO derived from the active TAO patients after corticosteroid treatment(16eyes).The tear concentration of Eotaxin-1 was measured per ELISA assay. Eotaxin-1protein expression was evaluated per Western Blot .
Results The highest Eotaxin-1 concentration in tears was in inactive TAO patients, followed by patients with active TAO and the controls per ELISA. Western Blot analysis indicated that Eotaxin-1 expression in inactive TAO was also higher than in active TAO and the controls.
Conclusion The changes of Eotaxin-1 expression in tears of patients with active and inactive TAO suggested that orbital inflammation may be involved in the ocular surface damage of TAO.
Keywords
Thyroid associated orbitopathy, Eotaxin-1, Ocular surface, Lacrimal gland, Tears
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This is a preprint. It has not completed peer review.
Research Article
cai kebo
shanghai jiaotong unniversity
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 29 Apr, 2021
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Ophthalmology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Purpose To explore changes of Eotaxin-1concentration in tears of thyroid associated
ophthalmopathy (TAO) patients
Methods This prospective observational study.16 patients with TAO (32 eyes) and 18
healthy volunteers (36 eyes) were recruited.TAO patients were divided into active TAO (16eyes) and inactive TAO derived from the active TAO patients after corticosteroid treatment(16eyes).The tear concentration of Eotaxin-1 was measured per ELISA assay. Eotaxin-1protein expression was evaluated per Western Blot .
Results The highest Eotaxin-1 concentration in tears was in inactive TAO patients, followed by patients with active TAO and the controls per ELISA. Western Blot analysis indicated that Eotaxin-1 expression in inactive TAO was also higher than in active TAO and the controls.
Conclusion The changes of Eotaxin-1 expression in tears of patients with active and inactive TAO suggested that orbital inflammation may be involved in the ocular surface damage of TAO.
Figure 1
Figure 2
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