This study uses a physiology-based pharmacokinetic model to predict Cadmium (Cd) concentrations in urine and blood through shellfish consumers. The main purpose focus on assessment of human health risk to Cd through exposure via shellfish in Taiwan. A Hill-based dose-response model is utilized to estimate renal dysfunction and peripheral arterial disease risks in humans after long-term exposure. Sensitivity analyses and Monte Carlo simulations are implemented to support the risk assessment of cadmium in humans. Results indicate that glomerular and tubular damage (GTD) is different between group ages and genders ranged from 17.8067% - 17.8072%, respectively. Results show that the peripheral arterial disease prevalence (PADP) ranges from 3.2505% - 4.5968% in male and ranges from 4.7168% - 7.0152% in female, respectively. The study concludes that Cd dietary consumption is very low, for males and for females in the different age groups. This study provides a foundation that can resolve the risk dose-dependency of Cd hazard.