Asthenospheric flow is a major driver of plate motions and lithosphere deformation. Previous studies have modelled the asthenospheric flow linked to the negative buoyancy of subducting slabs. However, orogenic systems associated with slab retreat are characterised by a more complex asthenospheric flow related to larger-scale processes including orogenic rotations, strain and flow partitioning or the along-strike variability of the subduction mechanics. Understanding deformation in such situations requires a bottom-up approach that simulates the asthenospheric flow and its effects on the overlying lithosphere. Here, we present a novel physical analogue modelling approach where gravity-driven asthenospheric flow is the main driver for lithospheric deformation. A constant volume asthenospheric flow is achieved by a novel inlet-outlet system that allows calibration of the flow velocity, which regulates the lithosphere-asthenosphere coupling. This approach induces asthenospheric flow, which provides an efficient mechanism for transferring deformation to a mechanically stratified lithosphere, where deformation can be studied at higher resolution compared to previous studies. Our approach is validated by a comparison with the slab retreat driven back-arc extension in the Carpathians-Pannonian system of Central Europe. Beyond slab retreat, our approach can be used for modelling asthenospheric flow in other plate tectonic settings.