To ensure a safe and stable CO2 storage, pressure responses at an observation well is expected to be an important and useful field monitoring items to estimate the CO2 storage behaviors and the aquifer parameters during and after injecting CO2, because it can detect whether the injected CO2 leaks to the ground surface or the bottom of the sea. In this study, pressure responses were simulated to present design factors such as well location and pressure transmitter of the observation well. Numerical simulations on the pressure response and the time-delay from pressure build-up after CO2 injection were conducted by considering aquifer parameters and distance from the CO2 injection well to an observation well. The measurement resolution of a pressure transmitter installed in the observation well was presented based on numerical simulation results of the pressure response against pressure build-up at the injection well and CO2 plume front propagations. Furthermore, the pressure response at an observation well was estimated by comparing the numerical simulation results with the curve of CO2 saturation and relative permeability. It was also suggested that the analytical solution can be used for the analysis of the pressure response tendency using pressure build-up and dimensionless parameters of hydraulic diffusivity. Thus, a criterion was established for selecting a pressure transducer installed at an observation well to monitor the pressure responses with sufficient accuracy and resolution, considering the distance from the injection well and the pressure build-up at the injection well, for future CCS projects.