This study focuses on a slope located in Nanjing, China, which has been continuously deforming since 2003. With a numerical tool continuum-discontinuum element method (CDEM) built in a hybrid finite-discrete framework, the damage evolutions of the slope were simulated and its potential influencing areas were predicted. In the analysis, a seepage model was used to assess the current state of the slope considering hydro-mechanical coupling. The strength reduction method was used to assess the factor of safety of the slope and the location and shape of unsafety blocks. According to the results of the stability analysis, a particle flow model was developed to provide the impact areas of potential landslide. The results show very high kinetic energy of the landslide which can move far away and cause blockage of the national highway nearby. Therefore, it is suggested to adopt comprehensive proactive defense measures to ensure the safety of people's lives and property.