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Research article
Risk factors and comorbidities associated with magnesium deficiency in pregnant women and women with hormone-related conditions: Analysis of a large real-world dataset
Kirill Starostin
Sanofi Aventis Russia
Corresponding Author
ORCiD: https://orcid.org/0000-0001-6488-7980
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
An accumulating body of literature indicates that magnesium deficiency is associated with a number of hormone-related conditions (HRC) in women, and epidemiological studies are needed to assess its prevalence and risk factors. Here, we present a secondary analysis of data pooled from four large observational studies that assessed magnesium deficiency among pregnant women and women with HRC across the Russian Federation.
Methods
The main objective of this analysis was to estimate the prevalence of magnesium deficiency in this population and to describe risk factors and comorbidities associated with low serum magnesium. Univariate logistic regression analysis was performed to identify the risk factors and comorbid conditions associated with an increased risk of low serum magnesium level.
Results
A total of 983 pregnant women and 9444 women with HRC were eligible for analysis. Prevalence of hypomagnesemia (magnesium serum level cut-off <0.66 mmol/L/<0.8 mmol/L) was 34.0%/78.9% in pregnant women and 21.4%/54.8% in women with HRC. The highest prevalence of magnesium deficiency was observed for osteoporosis and climacteric syndrome. Risk factors included diastolic blood pressure, previous pregnancy complications, infections and edema for pregnant women, and age, body mass index, and various comorbidities for women with HRC.
Conclusions
These results confirm the high prevalence of hypomagnesemia in pregnant women and women with HRC and underline the importance of routine screening, since risk factors are mostly non-specific.
Keywords
magnesium deficiency, osteoporosis, climacteric syndrome, pregnancy, hormone replacement therapy, oral contraceptives
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On 24 Aug, 2020
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Reviewer #3 agreed
On 22 Aug, 2020
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Subject Areas
Maternal & Fetal Medicine
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This preprint is under consideration at BMC Pregnancy and Childbirth. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Risk factors and comorbidities associated with magnesium deficiency in pregnant women and women with hormone-related conditions: Analysis of a large real-world dataset
Kirill Starostin
Sanofi Aventis Russia
Corresponding Author
ORCiD: https://orcid.org/0000-0001-6488-7980
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 3
Posted 20 Jan, 2021
No community comments so far
Submission checks complete
On 13 Jan, 2021
No comments provided
Editorial decision: Minor revision
On 28 Dec, 2020
Review #1 received
Received 19 Dec, 2020
Reviewer #2 agreed
On 17 Dec, 2020
Review #2 received
Received 17 Dec, 2020
Reviewers invited
Invitations sent on 16 Dec, 2020
Reviewer #1 agreed
On 16 Dec, 2020
Editor assigned
On 10 Dec, 2020
Submission checks complete
On 10 Dec, 2020
Editor invited
On 10 Dec, 2020
No comments provided
Editorial decision: Major revision
On 05 Nov, 2020
Review #3 received
Received 16 Sep, 2020
Review #5 received
Received 13 Sep, 2020
Review #6 received
Received 13 Sep, 2020
Review #1 received
Received 07 Sep, 2020
Review #2 received
Received 07 Sep, 2020
Reviewer #6 agreed
On 25 Aug, 2020
Reviewer #4 agreed
On 24 Aug, 2020
Reviewer #5 agreed
On 24 Aug, 2020
Review #4 received
Received 24 Aug, 2020
Reviewers invited
Invitations sent on 22 Aug, 2020
Reviewer #1 agreed
On 22 Aug, 2020
Reviewer #2 agreed
On 22 Aug, 2020
Reviewer #3 agreed
On 22 Aug, 2020
Editor assigned
On 22 Jul, 2020
First submitted
On 21 Jul, 2020
Submission checks complete
On 21 Jul, 2020
Editor invited
On 21 Jul, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Maternal & Fetal Medicine
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
An accumulating body of literature indicates that magnesium deficiency is associated with a number of hormone-related conditions (HRC) in women, and epidemiological studies are needed to assess its prevalence and risk factors. Here, we present a secondary analysis of data pooled from four large observational studies that assessed magnesium deficiency among pregnant women and women with HRC across the Russian Federation.
Methods
The main objective of this analysis was to estimate the prevalence of magnesium deficiency in this population and to describe risk factors and comorbidities associated with low serum magnesium. Univariate logistic regression analysis was performed to identify the risk factors and comorbid conditions associated with an increased risk of low serum magnesium level.
Results
A total of 983 pregnant women and 9444 women with HRC were eligible for analysis. Prevalence of hypomagnesemia (magnesium serum level cut-off <0.66 mmol/L/<0.8 mmol/L) was 34.0%/78.9% in pregnant women and 21.4%/54.8% in women with HRC. The highest prevalence of magnesium deficiency was observed for osteoporosis and climacteric syndrome. Risk factors included diastolic blood pressure, previous pregnancy complications, infections and edema for pregnant women, and age, body mass index, and various comorbidities for women with HRC.
Conclusions
These results confirm the high prevalence of hypomagnesemia in pregnant women and women with HRC and underline the importance of routine screening, since risk factors are mostly non-specific.
Figure 1
Figure 2
Figure 3
Figure 4