This study builds upon the evolving landscape of sustainable construction practices, where optimizing ready-mix concrete for strength, cost-efficiency, and reduced CO2 emissions is crucial in aligning with global environmental sustainability targets. Through an extensive analysis of diverse input parameters, including water-cement ratio, aggregate characteristics, additives, and their interactions with critical output parameters, this research has unveiled a substantial dependence on concrete performance, cost-efficiency, and environmental impact on cement selection and proportioning. This research emphasizes the pivotal role of cement in determining both the cost and CO2 emissions of concrete production, highlighting a notable positive correlation between cement content and compressive strength (R2 = 0.4946), and an even more pronounced correlation with CO2 emissions (R2 = 0.9529). This underlines the importance of optimizing cement use for balanced performance. Furthermore, the study reveals that while admixtures play a limited role in enhancing compressive strength (R2 = 0.0426), their impact on other concrete properties like workability and durability is significant. The optimization of concrete components, including a strategic reduction in admixture use, can lead to considerable cost and CO2 emission reductions, exemplified by a 5% cost decrease and a 7% drop in emissions with a 20% admixture reduction. Overall, these findings highlight the transformative impact of AI in concrete mix design, paving the way for more sustainable construction methods and contributing to global efforts to reduce the infrastructure sector's carbon footprint.