Introduction:
Migraine is a common chronic primary headache. Cognitive dysfunction has been found in patients with migraine after repetitive attacks. We used aspecific task paradigm called Go/No-Go to explore cognitive dysfunction, especially cortical inhibition.
Methods:
Our study included 30 participants with migraine and 30 healthy controls. We used the Go/No-Go task to analyze different Event related potential （ERP） components,such as latency or amplitude,to explore whether differences couldbe found. The two-tailed Pearson’s R correlation was performed between the clinical characteristics of patients with migraine,such as education, clinical course, duration, frequency, pain intensity, and ERP data. To test thedegree of independence between the clinical characteristics and ERP data, we performed multiple regression.
Results:
At the electrophysiological level, participants with migraine had longer latencies and larger amplitudes of N2 or P3 than the control group under the Go or No-Go conditions. In addition, significant two-tailed Pearson’s R correlations werefound in different areas. In particular, clinical characteristics were correlated with No-Go-N2 latency or amplitude in the frontal, central, or temporal area and correlated with No-Go-P3 latency or amplitude in the midline area of the frontal-central-parietal lobe. Finally, linear regression analysis revealed severalindependent factors that affected the N2 or P3 components in specific cortical areas.
Conclusion:
Our study revealed that repetitive attacks may influence response inhibition in patients with migraine. Abnormal changes in the inhibition process or inhibition supervision have been presented and interpreted by N2/P3 components under the Go/No-Go condition. Additionally, correlations were found between sex, education, pain, and N2/P3 components located in different regions. On the basis of our results, we found that patients with migraine have poor executive function, delayed response, abnormal response inhibition, and abnormal inhibitory monitoring, meriting the design and execution of future clinical studies.