The Study Designing A Sustainable Financing Model For Health Promotion Services In Iran

Background: Sustainable nancing for Health Promotion Services (HPS) has always been challenged and attracted the attention of health domain politicians. This study was conducted to aim at designing a sustainable health nancing model for HPS in Iran Methods: This combined study was conducted in two phases. First, the published comparative study of sustainable nancing for HPS and comprehensive study of the related current documents with this subject from 2005 to 2017 were used. In the second phase, the qualitative interviews for Iran’s current situation and capacities for sustainable health nancing of HPS and Focus Group Discussion (FGD) meetings for nalized the aforementioned model were used. Results: The rules and advantages of levying sin tax, the related stakeholders in sustainable health nancing, challenges and solutions of gathering, pooling, and purchasing of sustainable nancial resources have been extracted. Conclusion: According to the results, there is no political and national commitment to executing sustainable health nancing regulations in Iran. Lack of necessary infrastructures for their execution, resistance, and disagreement of harmful good industries are the barriers to executing these regulations. The model was suggested establishing a health promotion foundation and the permanent law for execution necessity and legitimacy of receiving public budget, sin tan, health tax, and duties will be provided.


Background
According to the related reports to the Universal Health Coverage, ve categories of services were considered as follows: preventive, curative, rehabilitation, palliative, and HPS (1). Health Promotion is one of the principles of community health development that helps to improve health. Health Promotion not only involves directs actions to strengthen the skills and abilities of individuals but also focuses on changing social, environmental, and economic situations to reduce their impact on the health of individuals and the general population (2).
HPS are signi cant as of their capability about prevention of non-communicable diseases, pathogenic reduction, improving quality of life, and reducing the burden of diseases in the society and they are divided into two groups of general HPS including quitting smoking, reducing alcohol consumption, increasing physical activities, improving the diet and the allocated HPS for speci c groups of patients (3)(4)(5). In addition to being precise in selecting interventions aiming at executing cost-effective interventions (6), sustainable long-term supports are needed to achieve sustainable consequences of health promotion interventions at the individual and public level and many interventions have no long-term effect because of no sustainable supports of the nancial kind (7). Depending on the regulation system, effective organization, and decentralization issue, the kind of intervention in the eld of HPS nancing have been different (8) and includes a wide range of central government`s capacities, local governments, social health insurance, or a combination of these methods (9).
In Iran, the nancial resources are not su cient for HPS (10,11) and there is no appropriate balance between treatment resources and health promotion (12,13). Covering these programs in social health insurance was di cult and these resources are often nanced by general taxes and they may be transferred to other programs in the allocation process (14). Among the countries which are the members of OECD, more than 90 % of health general costs have been allocated to healthcare, health promotion, and prevention programs. These have devoted on average 3.1% of these costs (Iceland with 0.7% is the minimum and Canada with 6.6% is the maximum) to themselves (15) .Also among 120 countries were surveyed during a study, only 2.9% of the total health expenditures have been spent on health promotion and prevention and regarding the change of disease pattern from communicable to non-communicable, resource transfer to health promotion and prevention is needed (16).
Regarding the status of Iran`s health system nancing and incremental trends in the costing rate in health (17), achieving the sustainable HPS nancing needs a serious determinants and health-oriented approach. On the other side, although Iran now has a young population regarding the elderly population in the future, it needs to develop HPS for preventing diseases and reducing treatment costs. These will have a positive effect on the contribution of elderly people to the society (14).
However, there is no speci c model to achieve Iran`s sustainable nancing for HPS and safe mechanisms for this, resource sustainability, and long-term nancing necessitates the need for research in countries.
Therefore, this study was conducted aiming at designing a sustainable health nancing model for HPS in Iran.

Methods
This is a mixed-method study that was conducted in two consequent phases during 2017-2019.
In the rst phase, the laws and regulations related to the provision of sustainable nancing for HPS in Iran and selected countries were determined using a comparative study since 1990 and content analysis of Iran`s published documents related to health promotion nancing from 2005 to 2017 (18, 19).
In the second phase, examining the current situation of Iran's health system in HPS nancing was done through qualitative interviews. To do this, the effective factors on HPS nancing and public health scope, effective and new strategies, and also the current capacities with emphasis on sustainable health nancing were examined qualitatively and based on semi-structured interviews aiming at determining the research pattern. The research population in this phase was all experts who were quali ed considering theoretical or practical viewpoints in nancing HPS and they were mainly in two groups of experts and decision-maker managers in nancing HPS that could enter the research in case they have ve years of work experience, minimum two years of management experience, executive experience and or research activities in the eld of nancing HPS and related elds and also the tendency to participate and collaborate in the interview. To determine the research sample, purposeful sampling and snowball approaches were used and data collection was continued up to saturation. 35 people were interviewed face to face who include the experts of Ministry of Health and Medical Education(MOHME) ( ) and Association of Non-smoking Life (1 person). Data collection tools in this phase were a semi-structured interview guide and voice recording equipment to record voice and event log forms related to the interview. Questions asked from the interviewees were somehow different based on their expertise in the eld of health nancing or health promotion.
Interview guide form including demographic information and the voluntary written consent was given to the participants to study and sign and aware satisfaction was considered so that the people are satis ed with recording the voice. Also, note-taking was done during the meetings and interviews. To be certain about data correctness and credibility in this research, different methods like getting help from supplementary opinions of two colleagues and one expert familiar with qualitative research, sending the written content of the interviews and the extracted codes to each of participants to revise and con rm the ndings, purposeful sampling, concurrent analysis with information collection and implementing the interview texts as soon as possible were used. The text of each interview was studied several times to achieve general perception. Interview analysis was done through framework analysis including ve stages of familiarization, recognition of conceptual framework, coding, table drawing, and mapping and interpretation. The researcher has coded each interview separately and extracted a list of these codes together with their relationship with the conceptual framework and a minimum of one code was allocated to each one of the sections with related information in the interviews. Then the codes were examined and changed when necessary. This process was repeated for each interview several times. In addition to the analysis during and after the study, to nalize the allocated codes to interview contents, a period of deep analysis in the contents of all interviews was done after the end of the interviews. To continue concluding the contents, each of the general concepts and their subcategories, table drawing was done so that the interviewee's opinions about each component of the conceptual pattern could be compared and the relationship between the pattern components and its subcategories determined. Wherever necessary, to understand the people's speech better, the original interview was referred to and the necessary contents were added. Then, nally, the interview texts were entered into ATLAS. Ti software to be classi ed.
In the nal step, using FGD, regarding the output of the previous phase, the preliminary model was provided in terms of suggested scenarios, and to nalize the presented model, two three-hour FGD meetings with the presence of professional experts in the Secretariat of Supreme Council of Food and Health Security of MOHME were held. In these meetings, the dimensions of the preliminary model, the list of potential and de facto sustainable nancial resources, and pooling and allocation mechanisms of gathered sustainable nancial resources were discussed. The organizations on the opposite stance with different resources of sustainable health nancing and sin tax and also moderate and expert people were invited to have all viewpoints. At the beginning of the meetings, the dimensions of the preliminary model of sustainable health nancing and the process of their pooling and costing for HPS that extracted from individual interviews were consulted and discussed so that the discussion was concentrated on better and to have the best conclusion from the meetings. To provide the solution to solve the challenges and disagreements among the stakeholders, the regulations and upstream documents of sustainable health nancing and the status of a burden of non-communicable diseases in Iran, and the number of death during the recent years were given to the participant's members. The fundamental and necessary challenges for sustainable health nancing and executing the regulations related to levy sin tax were discussed and the people gave different solutions and each solution was discussed with complementary discussions so that each solution is analyzed enough and examined from the different dimensions like advantages, disadvantages, and feasibility. During the meetings of politicians and experts who were familiar with the extracted challenges and prerequisites from the study results and the suggested executive model, they demonstrated their ideas in terms of research questions and meeting's aim. Getting permission from the people in the meetings and assuring the privacy of their information, the participants ' talks were recorded. Also, during the interviews, note-taking was used. Finally, after receiving the revision points and the complementary explanations, the suggested executive model was nalized.

Results
We skip the ndings of the comparative study and content analysis of documents because these ndings have been published in previous studies by Javadinasab et al (18,19).
After interviewing with experts in the eld of sustainable nancing and HPS or both, the features of sustainable health nancing and also HPS to which revenue of these resources can be allocated that have the biggest effect in reduction burden of non-communicable disease.

Main theme 1: sustainable health nancing for Iran
The resources through which sustainable nancing for health can be provided were somehow the same from the viewpoints of different interviewees; however, some of them suggested resources that are now not used in Iran. Some resources of sustainable health nancing which were suggested are as follows: "The resources of health nancing are entered from four sources; 10% targeted subsidies (that was not included in MOHME' budget and is allocated to rural insurance coverage and other affairs related to basic insurance), public budget, 1% of value-added tax (VAT), tobacco and beverages tax" (i4).
"One other resource of sustainable health nancing is a VAT that we went for it, but we did not act well" (i3).
"Another one is targeted subsidies. In the treatment system, the social welfare system and education system of targeted subsidies are paid special attention to. The investment of 1% of tax and VAT for health is a strong investment and the tax and VAT in other countries are between 17 to 20 percent of which a big share was speci ed for health. Charities and international help are also considered as resources, but in case of targeting them; some countries even targeted the resources of religious money" (i13).
"According to the budget law, the factories have a part of corporate social responsibility and according to the contract, they must spend 5% of their interest on corporate social responsibility that is now too scattered" (i11).
The interviewees also gave their opinions and reasons why some resources are called sustainable and also about the features of sustainable nancial resources as follows: "The reason for the sustainability of these resources is people participation in paying them and tax can be levied on the goods and services till they are consumed in the society" (i2).
Main theme 2: challenges of gathering sustainable nancial resources Three subjects of resource gathering, pooling, and allocating must be regarded about sustainable health nancing for each of which some challenges and solutions have been suggested in interviewees' talks. The interviewees said about the government and its role in the levying sin tax: "The revenue share resulting from sin tax from our public budget is too little and therefore our policy to earn revenue is not an intelligent policy. Intelligent here means we earn from in a way that it has the highest bene t for the government. Certainly, tariff increase, tra cking prevention, and sin tax are three good resources for government revenue" (i15).
"This budget viewpoint of the government about tobacco tax that it wants to use it as revenue and supply of its shortages makes a problem for us. We cannot count on the tobacco tax as a sustainable nancial resource for health. Last year, no budget of tobacco tax was allocated to health; of course, an amount was allocated to the health sector, but not for health" (i6). "Our policy is not to harm the industry and to close the factories at all. We must replace harmful goods with healthy products. Maybe at rst people's taste changes a little, but little by little, they will be eager for healthy goods and it is possible to allocate part of the tax to factory re nement" (i5).
Lack of general support is another current challenge of levying tax on harmful goods that some interviewees mentioned: "Public support to pay health tax is low as people believe that the government does not use its resources properly or they are looted and their costing is not speci ed. For instance, it is possible to give the whole tax to the Department of Education that is popular and the people will satisfactorily pay the tax" (i7).
"Certainly, resistance exists. These days in the bad economic conditions, wherever you tell the people we intend to raise the prices even for completely obvious tobacco, they resist as the consumer never tends to face price increase even for the most harmful goods" (i8).
"In Iran, there is no general support for the activity which must be done by the government, but in other countries, general support is there because they trust the government" (i17).

Main theme 3: solutions for gathering sustainable nancial resources
The interviewees said about political support attraction for gathering sin tax: "Last year, we examined the effect of scal policy on non-communicable disease prevention. The question was that it must become really clear for the society that why they pay this money? And the other question is that Arab countries around us have doubled the price of cigarettes, but in Iran, the price is still low. The reason is that the budget is low, but it was not the real reason and the people must know its real reason. For example, the discussion which was posed for a year or two about zzy drinks was that we got the tax from the producer, but if the consumer does not understand what he paid the money for, it will not have any effect on consumption" (i21).

Main theme 4: pooling solutions for sustainable nancial resources
Regarding pooling, the interviewees often agreed with the General Treasury of the country: "I do not agree with Plan and Budget Organization, but I agree with the Treasury; it means that the money enters the Treasury and was speci ed and then directly enters MOHME i.e. the Treasury deposits the money directly into MOHME or any other organization that will do the tasks and country models" (i1).
Main theme 5: the challenge of costing sustainable nancial resources "Usually the government gets the tax, but it does not allocate it to health and it is the same about beverage tax. The main culprit in this regard is the Budget and Plan Organization. In Hungary, 1.6% of tax is sin tax. Health policies in our country are several decades behind comparing the other countries. In the region, we are the last country regarding cigarette tax. In 2016, the cigarette tax decreased by 50%, but based on the law, it must be increased by 10% every year" (i5).
Main theme 6: solutions for costing sustainable nancial resources "The tax must be allocated to the source of production of pollution or harmful goods; for example, if we levy a tax on cigarette, we should spend part of that for increasing the quality of that or we can re ne pollution units. Therefore, the allocation for prevention is better than the allocation for treatment and it means preventing the effects" (i2).
"If the referral system and family physician are allowed to allocate part of these costs to themselves, we entered the purchasing stage. Also, it is possible to use it as subsidies for healthy products and health service development" (i1). Main theme 7: challenges of HPS "Our problem is mostly the approach and attitude; the politicians have mostly treatment viewpoint that is not health-oriented and global. Maybe, there are also other issues, but the most important issue is their viewpoint is not comprehensive and not about health promotion" (i9).

Main theme 8: solutions for HPS
"Certainly in the insurance system and public response system, we must allocate a box to health promotion. If there is a little tact in the prevention section, it is always said that prevention is better than treatment; if this is the motto, why does not this happen in the budget?" (i10).
"We have health promotion hospitals that were penetrated by treatment and health service management and they are working or we have health promotion schools or health promotion prisons and we can observe health promotion based on its physical space" (i20).
Main theme 9: the advantages of levying sin tax "When health promotion is done, several years later the third level diseases will be lowered and the doctors are forced to produce induced demand and all of these are related. You should not let the people out of that system earn money. You should decide if you want to do that work or not and the problem here is that the people who want to do health promotion are the same people who are doing a treatment. You should de ne your expectation of health promotion in return for the money you are given to" (i6).
"We have two aims by levying sin tax; one is the reduction of their consumption and second, earning money. If we want to detract the main part of health system revenue from sin tax, we expect that high consumption goes away so that we have high revenue. All ways must be used for sustainable health nancing and they are all complimenting each other; this tax is the sin tax which means the tax for guilt" (i9).
In the nal step of the research, according to the comparative study, recognition of the current situation of sustainable health nancing in the country and examination of the regulations related to this subject, the dimensions of the preliminary model of sustainable nancing for HPS were written that was shown in

3-1. Features of written models
In this model and regarding the fact that nancial resources of Iran's health system and also the research aims, some resources were selected for HPS nancing that has relative sustainability. The main dimensions of the research model include the following items: A: gathering sustainable nancial resources Government general revenue that is received from the following routes and deposited into State General Treasury or Tax Affairs Organization.
Health duties: includes sin tax (based on article 48 of incorporation law (2)) and providing the list is the responsibility of MOHME; maximum of 10% was determined for the tax. Based on the studies, the rate is not very effective on the main goal that is the reduction of the demands of the harmful goods in developing countries and the maximum must be increase. This tax must be received from the consumer. As a result, by levying a tax on harmful goods, the demand for these goods will be reduced that is directly effective on the reducing burden of noncommunicable disease and also, it provides a resource for health nancing, increases nutrition literacy and the people will replace harmful goods with healthy goods.
Health tax: includes tobacco tax and zzy drink tax (according to clause a and c of article 69 of incorporation law (2) Health nes: includes the ne of infringement of advertising harmful goods in media and other infringements of which the nes are deposited to the devoted revenue account of MOHME in the country's General Treasury.

Pollution tax
General tax

Public budget
The families through health donators or directly through people participation and participation in registration (investment foundation) International and national help like Emam Khomeini charity, the executive staff of Emam Khomeini decree, UN agencies, and WHO Religious money: as a potential resource of the sustainable health nancing part of that can be allocated for HPS through a mechanism.
Trade and social responsibility insurances of the companies: insurances as a third party are responsible to allocate part of the insurances received from people to prevention services and public health. This matter not only makes no additional costs for insurance but also it has been proved that it causes saving treatment costs, healthy elderliness and reduction burden of disease and it saves many nancial resources for this organization.

B: pooling
The suggestion of this model is establishing a foundation of society health promotion that pools all the received resources of the mentioned cases. This foundation can be of investment type. If an investment foundation is established, it will be under stock supervision that in addition to nancial transparency provides the possibility to invest part of resources and earning money from that. In the statute of the foundation, investment mechanism and how to buy HPS, etc. will be determined. This foundation will be under the supervision of the Supreme Council of Health and Food Security that based on clause seven of the permanent law of the president's development plans of Iran as the Council's director and the Ministers and directors of 13 Ministries are also counted as the main members of this Council.

C: allocation
Regarding the approval of national programs for four diseases (disease risk factors) of cardiovascular, cancer, respiratory and diabetes in the national committee of prevention and control of noncommunicable diseases, executing level one services of the national programs of these four diseases (risk factor) as promotion interventions will be nanced. In addition to general empowerment, culture and health literacy promotion, tobacco control, public exercise increase, nutrition improvement, and doing practical researches in line with the goals of national programs including programs to which the resources of health promotion foundation can be allocated. Finally, the result of conducted interventions for health promotion will be the reduction of four main risk factors of nutrition, physical activity, tobacco consumption, and lifestyle that results in society's health level promotion and reduction of noncommunicable diseases in the country.

Discussion
Considering the Iran`s health system nancing and the changing trends in the cost of health, achieving sustainable nancing for HPS requires serious determination and a holistic approach. The purpose of this study was to design a sustainable nancing model for HPS in Iran to help rectify this situation.
The research ndings showed that the revenue of tobacco, alcohol, gambling, non-alcoholic beverages, and luxury cars' tax in most countries are counted as a sustainable nancial resource of health promotion (1,9,18,20,21). There are different ideas in this regard in Iran and what was called a sustainable nancial resource in the documents and regulations and health general policies is sin tax.
Moreover, we can name health donators, VAT, targeted subsidies, religious money, part of a trade, and social responsibility insurances of factories and companies as sustainable nancial resources in case the regulations will be executed well (19). In Iran, a very small part of tobacco tax and sweetened drinks have been allocated to MOHME, and based on the determined task in Article 48 of incorporation law (2), only in 2018 succeeded to provide a list of harmful goods that regarding the economic and political conditions of the country, not even a penny of that was received (18). Denmark in 2011 was the rst country to introduce a fat tax and then levied a tax on non-alcoholic drinks, tobacco, and sugarsweetened beverages (22). In France, worry about high consumption of sugar among French people resulted in considering drink tax by the French government and then sweetener or sugar-sweetened beverages tax. At rst, this tax aimed to reduce overweight and obesity, especially in children and teenagers (23). Therefore, in an overview and through examining many current texts regarding food products which are the probable candidates of taxation, it seems that sugar-sweetened beverages and convenience foods are the most common food products considered for taxation (24).
On the other side, tobacco and alcohol tax is levied in almost all countries and different percentages have been determined for the sin tax. For example, in Denmark that has high tax revenue, 25% VAT for nonalcoholic drinks (0.02 euro per 330 milliliters), tobacco tax as 0.4 Euro per every 20 cigarettes, sweetened drinks tax, 25% for ice cream and chocolate, and saturated fat 1.81 Euro per kilogram is levied. In the article 48 of incorporation law (2), this percentage for Iran has been determined as a maximum of 10%. About tobacco also the tax per every cigarette of internal production, internal production with the shared brand and imported ones is different in different regulations that are determined based on the retail price and it is much lower than the tax rate in the other countries. It should be noticed that tax increases must be in a way that can cause consumption reduction. Unfortunately, in Iran, this rate has been xed for years and because of the little price increase that it causes, it is not very deterrent. A partial increase in tax causes the probability of unsuccessful cigarette consumption reduction. In this situation, people need big price shocks. This issue was examined in research and it was shown that a 10% increase in harmful products price in developed countries resulted in a 4% reduction and developing countries caused an 8% reduction of consumption (25). This issue in Iran where tobacco is usually sold at a lower price is challenging.
In terms of regulations and policies in the sustainable health nancing domain in Iran, there is no major lack of regulation and policy; however, the fundamental challenge is in the executive method and commitment about that of which the promotion requires su cient political support and unit consensus among stakeholders in different political levels. The existence of high supervision policies is of signi cance in execution and in the end, it is necessary to follow up the policy to take responsibility, transparency, trust, evaluation, and their effects (26,27).
Also, the ndings showed that one of the main and important barriers of executing regulation of levying tax and duties on harmful goods is lack of general support and resistance of public thinking regarding this subject especially when there would be no trust in government capability in this eld. Therefore, it is necessary to attract general support by increasing transparency and reporting correctly about costing these resources and showing health bene ts resulting from the execution of HPS at the society level. Political economy and stakeholder analysis in recognizing priorities in the special eld of each country can be helpful (28). In the study by Casper et al. in the Philippines, the strategy was to pay attention to the years saving after cigarette consumption reduction (29). Also, in Thailand, voting showed that the public highly supports the government's suggestion to establish a health promotion foundation with the budget resulting from added tobacco and alcohol tax and its allocation to health promotion activities including tobacco and alcohol consumption control, road accidents, nutrition, and exercise. Votes showed that civil society and non-pro t organizations supported tobacco control and other health promotion actions completely (16).
In some countries, even more than one foundation in different states were established for sustainable health nancing, the common aspect of most health promotion foundations is using tobacco or alcohol tax or sin tax as a nancial resource and also the goals of these foundations are the execution of activities and programs of health promotion including education, screening non-communicable diseases, ghting against tobacco and alcohol, nutrition improvement, physical activity increase and other activities of health and prevention. As it was said, the main aims of levying tobacco tax and sin tax are in the rst stage of consumption reduction and using healthy replaced goods (30), and in the second stage, sustainable nancing for HPS. Requesting for more resources to support health promotion activities through a formal budgeting system has many problems for approval. The low rate of the annual budget of HPS has changed every year and it changes in line with different government policies. It is believed that HPS are not effective and achievable only by MOHME. The reason is the executive policy of the MOHME may be limited in collaboration with other ministries involved and the organizations and companies which are not directly related to public institutes. Also, the bureaucratic system in the public structure may be delayed in executing health promotion activities. The other limitation is political interference and con ict of interest of people who have a high effect on the political process (17).
According to the research ndings, after gathering sustainable nancial resources and their pooling in the health promotion foundation, we must take action to buy the considered services related to health promotion using strategic purchase criteria that is one of the main components of nancing the health system. In strategic purchasing, service kind, quality, supplier, price, and payment method to the service provider are paid attention to and it is tried to buy the best services with the best quality and the best prices proportionate to consumers' needs (service recipients). Regarding that our goal in this research is buying HPS which are provided as universal health services and primary health care, we can buy service in the form of certain contracts with centers of these service providers including comprehensive centers of health services in the scope of described for primary health care services in the considered 4 national programs (a national program of diabetes, chronic respiratory diseases, cancer, and cardiovascular diseases) with determining quality and price.

Conclusions
The most important ndings of the research showed that there is a belief in sustainable nancing for HPS in Iran, but lack of political and national commitment to execute these regulations, the necessary infrastructures to execute and resistance, and disagreement of harmful goods industry especially tobacco industry in Iran prevents from executing these regulations. Based on nancing functions, after determining the rate of revenue, it must be decided about how to gather and also pooling location and purchase. Necessary transparency and responsiveness in these two dimensions are not very clear and also, the e ciency of its costing in different departments is questionable. Resource allocation does not follow a special goal or approach and in different years, allocation of resources with a wide range of changes has been distributed among this plans. Therefore, it seems that to organize this situation, we need a centralized structure and power to do resource pooling and management. Therefore it is suggested that the act of establishing a health promotion foundation and changing that to a permanent law for executive necessity and legitimacy of receiving public budget, health tax and duties is will be provided. On the other side, designing a model to provide a list of harmful goods and services seems necessary regarding the current problems in the eld of providing a list of harmful goods and services Limitations One of the limitations of the study qualitative stage was the lack of tendency of some participants to participate in face-to-face interviews in which the researcher tried to eliminate the research limitation by replacing a peer person. Also, regarding the fact of being qualitative, it was tried to consider the special ethical considerations of these types of studies as much as possible and doing individual interviews, explaining the signi cance of the study and voice record to analyze the interviews together with aware satisfaction was done. Referring to related organizations to collect data, an introduction letter was used. Ethics approval for this study was granted by the ethics committee of Science and Research Branch, Azad University as number IR.IAU.SRB.REC.1397.082. Individual informed consent was obtained before all interviews. Con dentiality for all study participants was assured. Also all methods were carried out in accordance with relevant guidelines and regulations.

Consent for publication
Not applicable.

Availability of data and material
All data generated or analyzed during this study are included in this published article. More details are available via formal writing to the correspondence author.