Readily available and rapid turn-around, bedside assays to measure the effect of the direct oral anticoagulants (DOACs) are not available. This study evaluates a new point-of-care (PoC) coagulometer to assess the anticoagulant effects of the DOACs and low molecular weight heparin. Studies were done in fresh spiked blood from healthy volunteers. PoC coagulometer baseline clotting times were half that of the manual whole blood clotting time (WBCT, legacy method) and exhibited a sensitivity to DOAC anticoagulation approximately twice that of WBCT. All %CV values for both methods were < 10% with most being < 5% indicating acceptable precision of both methods. R2 values for both clotting time and percent rise from baseline were > 0.98 indicating a strong correlation between the two methods. Replicate measurements for all subjects showed a maximum upper %CV value of 5.56% and a maximum upper value of all absolute %Differences of 5.5%, with both criteria meeting predefined acceptance criteria. The dose-response curves for all subjects were linear across the entire tested concentration ranges. The Perosphere Technology PoC coagulometer detects a range of therapeutic levels of the DOACs apixaban, rivaroxaban, edoxaban, as well as the low molecular weight heparin, enoxaparin, with high precision and sensitivity.