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Research Article
Jianye Jiang
Chengyang District People's Hospital of Qingdao
Corresponding Author
ORCiD: https://orcid.org/0000-0001-7636-7237
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This work is licensed under a CC BY 4.0 License. Read Full License
Currently, the synthesis of silver nanoparticles (AgNPs) was utilized for various life-saving biomedical applications. Herein, we report the synthesis and characterization of methylcellulose and hyaluronic acid (MC-HA) hydrogels containing AgNPs dressing materials were investigated for their wound healing efficiency to treat surgical excision wounds and the findings were studied and discussed. The effect of the ratio of AgNPs and MC-HA hydrogels on the gelation time, in vitro degradation, and equilibrium swelling of MC-HA/AgNPs hydrogels was examined. The prepared MC-HA hydrogels containing AgNPs were studied using various characterization techniques such as UV–Visible spectroscopy, Scanning electron microscopy (SEM), Transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectroscopy, and X-ray diffraction (XRD). The MC-HA/AgNPs showed excellent antimicrobial activity against S. aureus and E. coli, respectively. Additionally, the superior wound recovering potential of AgNPs with MC-HA hydrogels compared to conventional formulations was illustrated in vitro in animals utilizing visual observations and histological study. The MC-HA/AgNPs hydrogels showed excellent antimicrobial activity and burn wound healing. Therefore, these MC-HA hydrogels containing AgNPs have great potential medicinal applications in nursing care in children after surgery.
Keywords
AgNPs, MC-HA hydrogels, Antibacterial activity, Wound, Nursing care children
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CURRENT STATUS: Under Review
Version 1
Posted 14 May, 2021
No community comments so far
Editorial decision: Minor Revisions Needed
On 25 May, 2021
Reviews received
Received 12 May, 2021
Reviewers invited
Invitations sent on 12 May, 2021
Editor assigned
On 06 May, 2021
First submitted
On 02 May, 2021
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Subject Areas
Biopolymers
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A new preprint design is coming!
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This preprint is under consideration at Journal of Polymers and the Environment. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Jianye Jiang
Chengyang District People's Hospital of Qingdao
Corresponding Author
ORCiD: https://orcid.org/0000-0001-7636-7237
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 14 May, 2021
No community comments so far
Editorial decision: Minor Revisions Needed
On 25 May, 2021
Reviews received
Received 12 May, 2021
Reviewers invited
Invitations sent on 12 May, 2021
Editor assigned
On 06 May, 2021
First submitted
On 02 May, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Biopolymers
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Currently, the synthesis of silver nanoparticles (AgNPs) was utilized for various life-saving biomedical applications. Herein, we report the synthesis and characterization of methylcellulose and hyaluronic acid (MC-HA) hydrogels containing AgNPs dressing materials were investigated for their wound healing efficiency to treat surgical excision wounds and the findings were studied and discussed. The effect of the ratio of AgNPs and MC-HA hydrogels on the gelation time, in vitro degradation, and equilibrium swelling of MC-HA/AgNPs hydrogels was examined. The prepared MC-HA hydrogels containing AgNPs were studied using various characterization techniques such as UV–Visible spectroscopy, Scanning electron microscopy (SEM), Transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectroscopy, and X-ray diffraction (XRD). The MC-HA/AgNPs showed excellent antimicrobial activity against S. aureus and E. coli, respectively. Additionally, the superior wound recovering potential of AgNPs with MC-HA hydrogels compared to conventional formulations was illustrated in vitro in animals utilizing visual observations and histological study. The MC-HA/AgNPs hydrogels showed excellent antimicrobial activity and burn wound healing. Therefore, these MC-HA hydrogels containing AgNPs have great potential medicinal applications in nursing care in children after surgery.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
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