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Research Article
Shivaprakash Gangachannaiah
Kasturba Medical College Manipal
Corresponding Author
ORCiD: https://orcid.org/0000-0002-6359-4024
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This work is licensed under a CC BY 4.0 License. Read Full License
Ulcerative colitis is an inflammatory disorder affecting colonic mucosa, characterized by intense inflammation and mucosal damage. The currently available medical treatment is not completely safe and effective in alleviating the disease manifestations and its complications. The present study aimed to evaluate the protective effect of herbal product Trigonella foenum-graecum L. (TFG) seeds in acetic acid induced Ulcerative colitis (UC) in rats. The TFG extract was administered orally at two doses of 500 and 1000 mg/kg body weight. Compared to UC group, the TFG treated group showed significantly reduced severity of the disease as indicated by decreased Disease Activity Index (DAI) and decreased intensity of mucosal inflammation as indicated by macroscopic and histological scoring. Furthermore, biochemical assessment showed increased total protein, reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), and decreased malonaldehyde (MDA) and pro-inflammatory cytokine TNF-α levels in TFG treated group compared to the UC group. The study demonstrates the beneficial effect of TFG in UC by its natural anti-inflammatory and antioxidant properties.
Keywords
Acetic acid, Ulcerative colitis, Trigonella foenum-graecum L.
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research Article
Shivaprakash Gangachannaiah
Kasturba Medical College Manipal
Corresponding Author
ORCiD: https://orcid.org/0000-0002-6359-4024
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 13 May, 2021
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Ulcerative colitis is an inflammatory disorder affecting colonic mucosa, characterized by intense inflammation and mucosal damage. The currently available medical treatment is not completely safe and effective in alleviating the disease manifestations and its complications. The present study aimed to evaluate the protective effect of herbal product Trigonella foenum-graecum L. (TFG) seeds in acetic acid induced Ulcerative colitis (UC) in rats. The TFG extract was administered orally at two doses of 500 and 1000 mg/kg body weight. Compared to UC group, the TFG treated group showed significantly reduced severity of the disease as indicated by decreased Disease Activity Index (DAI) and decreased intensity of mucosal inflammation as indicated by macroscopic and histological scoring. Furthermore, biochemical assessment showed increased total protein, reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), and decreased malonaldehyde (MDA) and pro-inflammatory cytokine TNF-α levels in TFG treated group compared to the UC group. The study demonstrates the beneficial effect of TFG in UC by its natural anti-inflammatory and antioxidant properties.
Figure 1
Figure 2
Figure 3
Figure 4
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