Lightweight, nanoporous aerogel fibers are crucial for personal thermal management and specialized heat protection. However, wet-spinning methods, exemplified by aramid aerogels, inevitably form a dense outer layer, significantly reducing the volume fraction of efficient thermal barrier nanovoids and limiting the development of ultimate thermal resistance in fibers. Herein, we develop a microfluidic spinning method to prepare gradient all-nanostructure aramid aerogel fibers (GAFs). Benefiting from the simultaneous shear alignment and diffusion dilution of a good solvent within the channels, the precursor gel fibers assemble into a structure with a sparse exterior and dense interior, which reverses during supercritical drying to form sheath and core layers with average pore diameters of 150 nm and 600 nm, respectively. Experiments and simulations reveal that the gradient nanostructure creates high interfacial thermal resistance at heat transfer interfaces, resulting in a GAF radial thermal conductivity as low as 0.0228 W m–1 K–1, far below that of air and wet-spun aerogel fibers. Moreover, GAF's unique nano-entangled network efficiently dissipates stress, achieving exceptionally high tensile strength (29.5 MPa) and fracture strain (39.2%). This work establishes a correlation between multiscale nanostructures and superlative performance, thereby expanding the scope of aerogel applications in intricate environments.