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Yu Cai
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Background Glaucoma, an important cause of visual impairment in many countries, remains a common eye condition due to difficulties in its early diagnosis. We analyzed the characteristics of retinal arteries to add a valuable technology for helping the normal tension glaucoma (NTG) diagnosis. Methods This study included 51 patients with newly diagnosed NTG with hemifield defects and 60 age-matched controls. Peripapillary retinal arteriolar calibers (PRACs) photoed by non-mydriatic retinal camera were measured using ImageJ by two masked readers. We also performed spectral-domain optical coherence tomography to evaluate retinal nerve fiber layer thickness (RNFLT) and optic disc parameters. Their relations to retinal arteriolar calibers were investigated by univariate and multivariate linear regression. The area under the receiver operating characteristic curve (AUROC) was used to confirm the powers to detect NTG by PRACs. Results PRACs in four quadrants were significantly reduced in individuals with first diagnosed NTG (82 ± 15.1 μm, 80 ± 13.6 μm, 71 ± 11.6 μm, and 64 ±10.0 μm) compared with those in age-matched controls (101 ± 9.8 μm, 105 ± 8.7 μm, 90 ± 7.5 μm, and 82 ± 9.8 μm). Superotemporal and inferotemporal PRACs in the visual field-affected hemifield were narrower than those in the unaffected hemifield in NTG group ( P ≤0.004). Temporal PRACs in the RNFL unaffected hemifield were significantly narrower than in healthy eyes ( P <0.001). Superotemporal PRAC showed a significant correlation with superior RNFLT (β=0.659, P <0.001), and a similar relationship was found between inferotemporal PRAC and inferior RNFLT (β=0.227, P =0.015). The diagnostic capability of temporal PRACs was satisfactory (superotemporal PRAC; AUROC 0.983, cut-off value 84.7 μm, inferotemporal PRAC; AUROC 0.946, cut-off value 94.2 μm). Conclusions PRAC and infero temporal PRAC are valid parameters for discriminating patients with NTG.
Keywords
Peripapillary retinal artery; normal tension glaucoma; Discrimination accuracy
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CURRENT STATUS: Published
View the published article at BMC Ophthalmology.
Version 4
Posted 14 Oct, 2019
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Submission checks complete
On 07 Nov, 2019
Editorial decision: Accept
On 03 Sep, 2019
No comments provided
Editorial decision: Minor revision
On 29 Aug, 2019
No comments provided
Editorial decision: Minor revision
On 22 Aug, 2019
Editor assigned
On 20 Aug, 2019
Submission checks complete
On 19 Aug, 2019
Editor invited
On 19 Aug, 2019
No comments provided
Review #2 received
Received 20 Jul, 2019
Editorial decision: Major revision
On 20 Jul, 2019
Review #3 received
Received 16 Jul, 2019
Reviewer #3 agreed
On 09 Jul, 2019
Reviewer #2 agreed
On 08 Jul, 2019
Review #1 received
Received 25 Apr, 2019
Reviewers invited
Invitations sent on 02 Apr, 2019
Reviewer #1 agreed
On 02 Apr, 2019
Editor assigned
On 28 Mar, 2019
Submission checks complete
On 25 Mar, 2019
Editor invited
On 25 Mar, 2019
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Subject Areas
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A new preprint design is coming!
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See the published version of this preprint at BMC Ophthalmology.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Yu Cai
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Ophthalmology.
Version 4
Posted 14 Oct, 2019
No community comments so far
Submission checks complete
On 07 Nov, 2019
Editorial decision: Accept
On 03 Sep, 2019
No comments provided
Editorial decision: Minor revision
On 29 Aug, 2019
No comments provided
Editorial decision: Minor revision
On 22 Aug, 2019
Editor assigned
On 20 Aug, 2019
Submission checks complete
On 19 Aug, 2019
Editor invited
On 19 Aug, 2019
No comments provided
Review #2 received
Received 20 Jul, 2019
Editorial decision: Major revision
On 20 Jul, 2019
Review #3 received
Received 16 Jul, 2019
Reviewer #3 agreed
On 09 Jul, 2019
Reviewer #2 agreed
On 08 Jul, 2019
Review #1 received
Received 25 Apr, 2019
Reviewers invited
Invitations sent on 02 Apr, 2019
Reviewer #1 agreed
On 02 Apr, 2019
Editor assigned
On 28 Mar, 2019
Submission checks complete
On 25 Mar, 2019
Editor invited
On 25 Mar, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Internal Medicine Specialties
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Ophthalmology.
Background Glaucoma, an important cause of visual impairment in many countries, remains a common eye condition due to difficulties in its early diagnosis. We analyzed the characteristics of retinal arteries to add a valuable technology for helping the normal tension glaucoma (NTG) diagnosis. Methods This study included 51 patients with newly diagnosed NTG with hemifield defects and 60 age-matched controls. Peripapillary retinal arteriolar calibers (PRACs) photoed by non-mydriatic retinal camera were measured using ImageJ by two masked readers. We also performed spectral-domain optical coherence tomography to evaluate retinal nerve fiber layer thickness (RNFLT) and optic disc parameters. Their relations to retinal arteriolar calibers were investigated by univariate and multivariate linear regression. The area under the receiver operating characteristic curve (AUROC) was used to confirm the powers to detect NTG by PRACs. Results PRACs in four quadrants were significantly reduced in individuals with first diagnosed NTG (82 ± 15.1 μm, 80 ± 13.6 μm, 71 ± 11.6 μm, and 64 ±10.0 μm) compared with those in age-matched controls (101 ± 9.8 μm, 105 ± 8.7 μm, 90 ± 7.5 μm, and 82 ± 9.8 μm). Superotemporal and inferotemporal PRACs in the visual field-affected hemifield were narrower than those in the unaffected hemifield in NTG group ( P ≤0.004). Temporal PRACs in the RNFL unaffected hemifield were significantly narrower than in healthy eyes ( P <0.001). Superotemporal PRAC showed a significant correlation with superior RNFLT (β=0.659, P <0.001), and a similar relationship was found between inferotemporal PRAC and inferior RNFLT (β=0.227, P =0.015). The diagnostic capability of temporal PRACs was satisfactory (superotemporal PRAC; AUROC 0.983, cut-off value 84.7 μm, inferotemporal PRAC; AUROC 0.946, cut-off value 94.2 μm). Conclusions PRAC and infero temporal PRAC are valid parameters for discriminating patients with NTG.
Figure 1
Figure 2
Figure 3
This is a list of supplementary files associated with this preprint. Click to download.
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