This preprint is under consideration at BMC Cancer. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
Research Article
Ning Lang
Peking University Third Hospital
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: To investigate the value of an intravoxel incoherent motion (IVIM) MRI for discriminating spinal metastasis from tuberculous spondylitis.
Methods: This study included 50 patients with spinal metastasis (32 lung cancer, 7 breast cancer, 11 renal cancer), and 20 tuberculous spondylitis. All patients underwent IVIM MRI at 3.0T before treatment. The IVIM parameters including single-index model ( Apparent diffusion coefficient (ADC)-stand), double exponential model (ADCslow，ADCfast and f) and stretched-exponential model parameters (distributed diffusion coefficient (DDC) and α) were acquired. Two radiologists separately measured these parameters for each lesion through drawing region of interest. Receiver operating characteristic (ROC) and the area under the ROC curve analysis was used to evaluate the diagnostic performance. Each parameter was substituted into the Logistic regression model to determine the meaningful parameters, and the combined diagnostic performance was evaluated.
Results: The ADCfast and f showed significant differences between spinal metastasis and tuberculous spondylitis. (for all, p < 0.05). The Logistic regression model results showed that ADCfast and f were independent factors affecting the conclusion (P<0.05). The AUC values of ADCfast and f were 0.823 (95%CI:0.719 to 0.927) and 0.876 (95%CI: 0.782 to 0.969), respectively. ADCfast combined with f showed the highest AUC value of 0.925 (95%CI: 0.858 to 0.992). Additional significant differences were found in ADCstand, ADCslow, DDC and α among different metastasis type.
Conclusions: IVIM MR imaging may be helpful for differentiating spinal metastasis from tuberculous spondylitis and may be used to detect the origin tumor for those patients who could not identify primary tumors, and provide help for clinical treatment.
Keywords
Intravoxel incoherent motion, Diffusion, Magnetic resonance imaging, Metastasis, Spine
Figure 1
Figure 2
Figure 3
No competing interests reported.
Loading...
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Revision
Version 1
Posted 19 May, 2021
No community comments so far
Editorial decision: Major revision
On 08 Oct, 2021
Reviews received
Received 01 Oct, 2021
Reviewers agreed
On 23 Sep, 2021
Reviews received
Received 02 Jun, 2021
Reviewers agreed
On 27 May, 2021
Reviewers agreed
On 26 May, 2021
Reviewers invited
Invitations sent on 25 May, 2021
Editor assigned
On 18 May, 2021
Editor invited
On 18 May, 2021
Submission checks complete
On 18 May, 2021
First submitted
On 05 May, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Learn more about our company.
A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
This preprint is under consideration at BMC Cancer. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Ning Lang
Peking University Third Hospital
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Revision
Version 1
Posted 19 May, 2021
No community comments so far
Editorial decision: Major revision
On 08 Oct, 2021
Reviews received
Received 01 Oct, 2021
Reviewers agreed
On 23 Sep, 2021
Reviews received
Received 02 Jun, 2021
Reviewers agreed
On 27 May, 2021
Reviewers agreed
On 26 May, 2021
Reviewers invited
Invitations sent on 25 May, 2021
Editor assigned
On 18 May, 2021
Editor invited
On 18 May, 2021
Submission checks complete
On 18 May, 2021
First submitted
On 05 May, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: To investigate the value of an intravoxel incoherent motion (IVIM) MRI for discriminating spinal metastasis from tuberculous spondylitis.
Methods: This study included 50 patients with spinal metastasis (32 lung cancer, 7 breast cancer, 11 renal cancer), and 20 tuberculous spondylitis. All patients underwent IVIM MRI at 3.0T before treatment. The IVIM parameters including single-index model ( Apparent diffusion coefficient (ADC)-stand), double exponential model (ADCslow，ADCfast and f) and stretched-exponential model parameters (distributed diffusion coefficient (DDC) and α) were acquired. Two radiologists separately measured these parameters for each lesion through drawing region of interest. Receiver operating characteristic (ROC) and the area under the ROC curve analysis was used to evaluate the diagnostic performance. Each parameter was substituted into the Logistic regression model to determine the meaningful parameters, and the combined diagnostic performance was evaluated.
Results: The ADCfast and f showed significant differences between spinal metastasis and tuberculous spondylitis. (for all, p < 0.05). The Logistic regression model results showed that ADCfast and f were independent factors affecting the conclusion (P<0.05). The AUC values of ADCfast and f were 0.823 (95%CI:0.719 to 0.927) and 0.876 (95%CI: 0.782 to 0.969), respectively. ADCfast combined with f showed the highest AUC value of 0.925 (95%CI: 0.858 to 0.992). Additional significant differences were found in ADCstand, ADCslow, DDC and α among different metastasis type.
Conclusions: IVIM MR imaging may be helpful for differentiating spinal metastasis from tuberculous spondylitis and may be used to detect the origin tumor for those patients who could not identify primary tumors, and provide help for clinical treatment.
Figure 1
Figure 2
Figure 3
No competing interests reported.
Loading...