Background
To assess vessel density, perfusion density among emmetropic and myopic person, and to demonstrate detailed changes in superficial retinal microvascular network.
Methods
This was a single-centered, cross-sectional study of 120 participants. Emmetropic, low, moderate and high myopic group each account for 1/4. Enface 3mmx3mm optical coherence tomography angiography images were obtained using Cirrus™ HD-OCT 5000. Quantifiable measure of vessel density, perfusion density and foveal avascular zone were performed by AngioVue software.
Results
Gender, age, SBP, DBP, MOPP and IOP showed no differences among emmetropic and myopic groups. In inferior quadrant, vessel density and perfusion density of emmetropic and low myopia group showed statistical significance from moderate and high myopia group (all P<0.05). In temporal quadrant, vessel density and perfusion density of emmetropic, low and moderate myopia group showed statistical significance from high myopia group (all P<0.05).In emmetropic group, vessel density and perfusion density showed no difference among superior, inferior, temporal and nasal quadrants. In low myopic group, vessel density and perfusion density of temporal quadrant showed statistical significance from superior, inferior and nasal quadrants (all P<0.05). In moderate and high myopic group, vessel density and perfusion density of superior quadrant showed statistical significance from temporal quadrant (all P<0.05) and inferior quadrant(all P<0.05) . And vessel density of nasal quadrant showed statistical significance from inferior quadrant in moderate myopic group(P=0.039) .
Conclusion
Along with the increase of myopia degree, vessel density and perfusion density of inferior and temporal quadrants showed a statistically significant tendency of decrease. Vessel density and perfusion density of nasal quadrant showed a relatively decreasing tendency. Closer attention should be paid to moderate myopia.