To analyze the global scientific output of health-related quality of life (HRQoL) research and figure out general trends and hotspots in HRQoL.
HRQoL research articles were collected from the Web of Science (WOS) database between 2000 and 2019. A bibliometric analysis was performed based on the number of articles, citations, published journals, authors' address and keywords. Descriptive analysis, visualization of geographic distribution and keyword clustering analysis were applied to the collected data.
The annual number of articles showed a growth over the past twenty years, but the annual TA (Total Citations) and annual CPA (Citations Per Article) were both in decreasing trends. Articles about HRQoL were more likely to be published in journals of multi-subject categories, The HRQoL research was mainly distributed across North America and Europe throughout the twenty years and ushered in a vigorous development worldwide after 2015. Research institutions with high productivity in HRQoL research were more inclined to collaborate, but the cooperation strength between domestic institutions was much greater than that between international institutions. There were a large number of author keywords were only used once or twice during 2000 to 2019. SF-36, EQ-5D, depression, obesity, disability, oncology, fatigue were identified as hot research areas. Also, dementia, HIV, chronic disease, OHRQoL, PRO, stress, well-being, the elderly, women and children may become new hotspots in future research.
This study provided an overall perspective on global research trends and hotspots in HRQoL research, as well as a potential guide for future research. Researchers need to strengthen international cooperation, as well as pay more attention to the standardization and unity of keywords in future study.

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Posted 03 Aug, 2020
Received 20 Nov, 2020
On 30 Oct, 2020
Received 15 Sep, 2020
Invitations sent on 07 Sep, 2020
On 07 Sep, 2020
On 30 Jul, 2020
On 29 Jul, 2020
On 29 Jul, 2020
On 27 Jul, 2020
Posted 03 Aug, 2020
Received 20 Nov, 2020
On 30 Oct, 2020
Received 15 Sep, 2020
Invitations sent on 07 Sep, 2020
On 07 Sep, 2020
On 30 Jul, 2020
On 29 Jul, 2020
On 29 Jul, 2020
On 27 Jul, 2020
To analyze the global scientific output of health-related quality of life (HRQoL) research and figure out general trends and hotspots in HRQoL.
HRQoL research articles were collected from the Web of Science (WOS) database between 2000 and 2019. A bibliometric analysis was performed based on the number of articles, citations, published journals, authors' address and keywords. Descriptive analysis, visualization of geographic distribution and keyword clustering analysis were applied to the collected data.
The annual number of articles showed a growth over the past twenty years, but the annual TA (Total Citations) and annual CPA (Citations Per Article) were both in decreasing trends. Articles about HRQoL were more likely to be published in journals of multi-subject categories, The HRQoL research was mainly distributed across North America and Europe throughout the twenty years and ushered in a vigorous development worldwide after 2015. Research institutions with high productivity in HRQoL research were more inclined to collaborate, but the cooperation strength between domestic institutions was much greater than that between international institutions. There were a large number of author keywords were only used once or twice during 2000 to 2019. SF-36, EQ-5D, depression, obesity, disability, oncology, fatigue were identified as hot research areas. Also, dementia, HIV, chronic disease, OHRQoL, PRO, stress, well-being, the elderly, women and children may become new hotspots in future research.
This study provided an overall perspective on global research trends and hotspots in HRQoL research, as well as a potential guide for future research. Researchers need to strengthen international cooperation, as well as pay more attention to the standardization and unity of keywords in future study.

Figure 1

Figure 2

Figure 3

Figure 4
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