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Protocol
Mihai-Calin Pavel
Hospital Universitari de Tarragona Joan XXIII
Corresponding Author
ORCiD: https://orcid.org/0000-0003-2370-6842
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Introduction
The primary objective of this systematic review is to assess the effect of neoadjuvant chemotherapy on liver regeneration after liver resection (LR) or portal vein embolization (PVE) in patients with liver metastasis from colo-rectal cancer. The secondary objectives are to evaluate the impact of the type of chemotherapy, number of cycles and time between end of treatment and procedure (LR or PVE) and to investigate whether there is an association between degree of hypertrophy and postoperative liver failure.
Methods
The design of this systematic review will follow the current recommendations of PRISMA. After an exhaustive literature search with pre-established criteria, two researchers will individually screen the identified records, according to a list of inclusion and exclusion criteria. Primary outcome will be future liver remnant regeneration rate. All data will be registered in a predesigned database. In the event of a substantial heterogeneity of selected articles, a narrative systematic review will be performed.
Discussion
The results of this systematic review may help to better identify the patients affected by liver metastasis that could present low regeneration rates after neoadjuvant chemotherapy. These patients are at risk to develop liver failure after extended hepatectomies and therefore are not good candidates for such aggressive procedures.
Systematic Review Registration
PROSPERO registration number: CRD42020178481 (July 5th 2020).
Keywords
liver regeneration, liver resection, portal vein embolization, colorectal cancer liver metastasis, neoadjuvant chemotherapy
This is a list of supplementary files associated with this preprint. Click to download.
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Peer Review Timeline
CURRENT STATUS: Published
View the published article at Systematic Reviews.
No community comments so far
Editorial decision: Accept
On 25 Nov, 2020
Editor assigned
On 17 Nov, 2020
Submission checks complete
On 17 Nov, 2020
Editor invited
On 17 Nov, 2020
No comments provided
Review #2 received
Received 13 Nov, 2020
Reviewer #2 agreed
On 08 Nov, 2020
Reviewer #1 agreed
On 07 Nov, 2020
Review #1 received
Received 07 Nov, 2020
Editor assigned
On 07 Nov, 2020
Reviewers invited
Invitations sent on 07 Nov, 2020
Submission checks complete
On 07 Nov, 2020
Editor invited
On 07 Nov, 2020
No comments provided
Editorial decision: Minor revision
On 02 Nov, 2020
Reviewers invited
Invitations sent on 29 Oct, 2020
Reviewer #1 agreed
On 29 Oct, 2020
Reviewer #2 agreed
On 29 Oct, 2020
Review #1 received
Received 29 Oct, 2020
Review #2 received
Received 28 Oct, 2020
Editor assigned
On 19 Oct, 2020
Submission checks complete
On 18 Oct, 2020
Editor invited
On 18 Oct, 2020
Version 1
Posted 02 Aug, 2020
No comments provided
Editorial decision: Revise before peer review
On 15 Oct, 2020
Editor assigned
On 14 Oct, 2020
Editor invited
On 13 Oct, 2020
Submission checks complete
On 28 Jul, 2020
First submitted
On 27 Jul, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Oncology
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A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
See the published version of this preprint at Systematic Reviews.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Protocol
Mihai-Calin Pavel
Hospital Universitari de Tarragona Joan XXIII
Corresponding Author
ORCiD: https://orcid.org/0000-0003-2370-6842
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at Systematic Reviews.
No community comments so far
Editorial decision: Accept
On 25 Nov, 2020
Editor assigned
On 17 Nov, 2020
Submission checks complete
On 17 Nov, 2020
Editor invited
On 17 Nov, 2020
No comments provided
Review #2 received
Received 13 Nov, 2020
Reviewer #2 agreed
On 08 Nov, 2020
Reviewer #1 agreed
On 07 Nov, 2020
Review #1 received
Received 07 Nov, 2020
Editor assigned
On 07 Nov, 2020
Reviewers invited
Invitations sent on 07 Nov, 2020
Submission checks complete
On 07 Nov, 2020
Editor invited
On 07 Nov, 2020
No comments provided
Editorial decision: Minor revision
On 02 Nov, 2020
Reviewers invited
Invitations sent on 29 Oct, 2020
Reviewer #1 agreed
On 29 Oct, 2020
Reviewer #2 agreed
On 29 Oct, 2020
Review #1 received
Received 29 Oct, 2020
Review #2 received
Received 28 Oct, 2020
Editor assigned
On 19 Oct, 2020
Submission checks complete
On 18 Oct, 2020
Editor invited
On 18 Oct, 2020
Version 1
Posted 02 Aug, 2020
No comments provided
Editorial decision: Revise before peer review
On 15 Oct, 2020
Editor assigned
On 14 Oct, 2020
Editor invited
On 13 Oct, 2020
Submission checks complete
On 28 Jul, 2020
First submitted
On 27 Jul, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Oncology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at Systematic Reviews.
Introduction
The primary objective of this systematic review is to assess the effect of neoadjuvant chemotherapy on liver regeneration after liver resection (LR) or portal vein embolization (PVE) in patients with liver metastasis from colo-rectal cancer. The secondary objectives are to evaluate the impact of the type of chemotherapy, number of cycles and time between end of treatment and procedure (LR or PVE) and to investigate whether there is an association between degree of hypertrophy and postoperative liver failure.
Methods
The design of this systematic review will follow the current recommendations of PRISMA. After an exhaustive literature search with pre-established criteria, two researchers will individually screen the identified records, according to a list of inclusion and exclusion criteria. Primary outcome will be future liver remnant regeneration rate. All data will be registered in a predesigned database. In the event of a substantial heterogeneity of selected articles, a narrative systematic review will be performed.
Discussion
The results of this systematic review may help to better identify the patients affected by liver metastasis that could present low regeneration rates after neoadjuvant chemotherapy. These patients are at risk to develop liver failure after extended hepatectomies and therefore are not good candidates for such aggressive procedures.
Systematic Review Registration
PROSPERO registration number: CRD42020178481 (July 5th 2020).
This is a list of supplementary files associated with this preprint. Click to download.
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