Incidence and predictors of diabetic ketoacidosis among children with diabetes in west and east gojjam zone referral hospitals north west Ethiopia, 2019.

doi:10.21203/rs.3.rs-50229/v2

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Incidence and predictors of diabetic ketoacidosis among children with diabetes in west and east gojjam zone referral hospitals north west Ethiopia, 2019.

https://doi.org/10.21203/rs.3.rs-50229/v2

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published 03 Nov, 2020

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Background: Recurrent diabetic ketoacidosis in patients with already diagnosed diabetic mellitus remains a relevant problem in pediatric with an incidence of 1–10% per patient. Children may die due to cerebral edema and had significant mortality (24%) and morbidity (35%).

Objective: We assess the incidence and predictors of diabetic ketoacidosis among diabetic children at East and West Gojjam zone referral hospitals, North West Ethiopia, 2019.

Methods: An institution-based retrospective follow up study was conducted on children who were registered from January 1, 2014, to January 1, 2019. Epi data version 3.1 & Stata 14 were used for data entering and analysis respectively.

Result: A total of 354 children were included from this 207(58.5%) had diabetic ketoacidosis. The overall incidence rate of diabetic ketoacidosis was 2.27/100 children/month of observation. Age <5 years (AHR: 3.52, 95% CI (2.25, 5.49), non-adherence (AHR: 1.54, 95% CI (1.11, 2.14), inappropriate insulin storage (AHR: 1.36, 95% CI (1.008, 1.85), presence of upper respiratory tract infections during diabetic ketoacidosis diagnose (AHR: 2.22, 95% CI (1.11, 4.45) and preceding gastroenteritis (AHR: 2.18, 95% CI (1.07, 4.44) were significant predictors.

Conclusion: age <5 years old, non-adherence, inappropriate insulin placement at home, Preceding gastroenteritis, and presence of upper respiratory tract infections at the time of diabetic ketoacidosis development were significant predictors. Hence, assessing and close monitoring as well as strengthened diabetic education should be given for the above predictors.

Pediatrics

diabetic ketoacidosis

incidence

diabetic mellitus

and children

Diabetic Ketoacidosis (DKA) is a state of acute metabolic stress, results when the body suffers due to absolute or relative insulin deficiency for the metabolism of glucose[1]. Globally, recurrent-DKA in patients with established diabetic mellitus (DM) remains a relevant problem in pediatric. The risk of DKA in established diabetes according to the international society of pediatric and adolescent diabetes is 1–10% per patient per year in children [2]. The incidence of recurrent DKA is different across the world due to the quality of health care services and socioeconomic circumstances. The incidence of DKA in established diabetes children in the US was 8 per 100 person-years [3], in Sweden 3.2-3.6/100 patient-years [4] in French o.7% [5], in Indonesia 41.4% [6], in Germany and Austria 6% [7] and in Italy 38.5% [8]. Were as in Africa the data on the incidence of DKA in established diabetes is scarce, but some studies report a high frequency of DKA in Sudan 92.1% [9], north-western Nigeria 62.2% [10], in South Africa 69.8% [11]. Similarly, in Ethiopia, to our knowledge the incidence of DKA in established diabetes is not studied, rather a study in Addis Ababa showed that the prevalence of DKA at diagnosis of DM is 35.8% [12].

DKA is the most common cause of morbidity and mortality among children. It increases the risk of cerebral edema and cognitive deficits [13, 14]. A study showed that the risk of developing cerebral edema was 12.4 per 1000 episodes of DKA which was higher than non-DKA DM patients (3.8 per 1000). It has a signiﬁcant mortality (24%) and morbidity (35%) [15]. Also, DKA has a crisis in terms of health care costs and missed work, and school days. One DKA-related hospital admission ranges from US$4125 to US$11 196 costs [16]. The risk of DKA in established diabetes increased in patients with younger age (< 5 yrs.), infection, insulin omission, lower socioeconomic status, and lower parental education [17]. Despite an increase in diabetes in our country, there is limited study in Ethiopia on the incidence and predictors of diabetic ketoacidosis in children thus; the study aims to fill this gab.

Study setting

The study was conducted in the two referral hospitals (Debre-Markos referral hospital and Felege-Hiwot referral hospital) of East and West Gojjam zones in Amara regional state North West Ethiopia. These hospitals serve more than 3.5 million and 5 million population in their catchment area respectively. Apart from other services, both referral hospitals offer diabetic treatment services.

Study design

Five years of institution-based retrospective follow up study was conducted.

Inclusion and Exclusion criteria

Children age less than 15 years old and diagnosed with DM with follow up care from January 1, 2014, to January 1, 2019, were included and Child who was developing DKA at the first diagnosis of DM and charts which was lost during the study period was excluded from the study.

Data collection

Firstly we assessed the total DM caseload in the database on the registered follow-up chart/form from the discharge catalog of admitted patient's pediatric ward, emergency, and outpatient department from January 1, 2014, to January 1, 2019. Then medical registration number of all diabetic pediatric patients was sorted. After this, a simple random technique was applied to select the required sample size of 376 diabetic children. Finally, trained BSC nurses working at diabetic clinics collected the data from registered patient charts in the hospital by using a checklist that measures the socio-demographic, clinical, treatment characteristics, and information on glycemic control of the children.

Outcome measures

Diabetic ketoacidosis was considered, in the context of hyperglycemia (Blood glucose measurement >200 mg/dl or >11 mmol/L) and any of the following present: a blood bicarbonate level <15 mmol/L, and/or a pH <7.30, and/or a DKA diagnosis mentioned in the medical records and/or Ketone body in the urine [2]. Appropriate insulin storage was considered in patients who store insulin in refrigerator between 2 to 8 degree Celsius and keep away from heat and light. If refrigerator is not available appropriate insulin storage was considered in patients who kept Vials at room temperature (20 to 25 degree Celsius) and protected from sunlight and heat for maximum of 6 weeks, and 4 weeks (if the temperature goes up to 30 degree Celsius or within hot seasons) after initial use, in a clean plastic box (plastic container with cotton) [18]

Ethical consideration

After the approval of the proposal, ethical clearance was obtained from the school of nursing and midwifery, college of health sciences, Addis Ababa University. Then permission letter was written to Debre Markos and Felege Hiwot referrals hospitals to collect the data. We had taken permission from hospital medical directors and data was kept confidential. Informed consent was not required, due to data was taken from chart review only.

Statistical analysis

The collected data were coded and entered into Epi data version 3.1 and cleaned and transferred to Stata version 14 for further analysis. The incidence rate of DKA was estimated per 100 DM children per month. The Kaplan Meier estimator was used to estimate the median time to develop DKA during the treatment period and log-rank tests, to compare survival curves. The predictors of DKA were analyzed by the cox proportional hazard model with hazard ratio, 95% CI. The statistical test was considered significant at a P value of less than 0.05. Covariates and proportional hazard assumptions were checked using a log-log plot and goodness of fit by Schoenfeld residual test.

Socio-demographic characteristics

Out of 376 children's clinical profile reviewed, 354 were enrolled in the study. The rest of the sample 22 (5.8) was incomplete data. From 354 children, more than half 159 (55.1%) were males and more than half 189 (53.4) of them were from a rural area. The mean age of the children at the time of DM diagnosis was 8.21 years with SD $\pm$ 3.94 years (Table 1).

Table 1

socio-demographic characteristics of DM diagnosed children at East &West Gojjam Zone referral hospitals, Northwest Ethiopia, 2019
Variable		Frequency N(354)	Percent %
Sex	Male	195	55.1
Sex	Female	159	44.9
Residence	Urban	165	46.6
Residence	Rural	189	53.4
Age	< 5 year	93	26.3
	5–9 year	116	32.8
	>=10 year	145	41.0

Clinical characteristics

Majority 295 (83.3%) of children have normal weight for age. Around 258 (72.9%) have no family history of DM. The majority of children 317(89.5%) were diagnosed with type 1 DM, the rest were type 2 DM. About one-third of participants 119(33.6%) have got preceding infection; of which 346(97.7%) had upper respiratory tract infection (URTI) followed by skin fungal infection 53 (15%) and pneumonia 19(5.4%) (Table 2).

Table 2

clinical characteristics of DM diagnosed children at East &West Gojjam Zone referral hospitals, Northwest Ethiopia, 2019
Variable		Frequency (354)	Percent %
Weight for age	Normal	295	83.3
	under weight	58	16.4
	over weight	1	0.3
Weight for height	Normal	306	86.4
Weight for height	under weight	48	13.6
Preceding infection	Fungal skin infection	53	15
	Pneumonia	19	5.4
	Tuberculosis	3	0.8
	Tonsillitis	5	1.4
	Gastroenteritis	15	4.2
	Urinary tract infection	14	4
	Hepatitis	5	1.4
	otitis media	7	2
	chicken pox	2	0.6
	Mengitis	1	0.3
	Upper respiratory tract infection	346	97.7
	Other	18	5.1

Nearly one-third of children 120(33.9%) had acute illness at the time of DKA development. Of which 53(14.97%) had pneumonia followed by urinary tract infection (UTI) 28(7.9%) and gastroenteritis 22 (6.2%) (figure: 1).

About 92(26.0%) of children had comorbidity of which 55(15.5%) had severe acute malnutrition (SAM) (figure: 2).

About 105 (29.7%) of children were hypoglycemic, 4(1.1%) had acute kidney injury and 1(0.3%) had chronic kidney injury after starting follow up for DM.

Treatment related variables of DM diagnosed children

One fourth 171 (48.3%) of the children had a history of medication adherence and about 333(94.5) children used insulin and 8(2.3%) used hypoglycemic agent for treatment, but, about 13(3.7%) not take any drug. About 247 (69.77%) children stored insulin appropriately at home and about three fourth 265(74.9) of children had poor glycemic control.

Incidence of diabetic ketoacidosis after DM diagnosis

Out of 354 children enrolled, 207(58.5%) were developed DKA, with a mean follow up time of 25.72 months with 95% CI (24.1, 27.43). The children were followed a minimum of 1 month and a maximum of five years. The incidence rate of DKA was calculated using cases/month as a denominator for the entire cohort. The overall incidence rate of DKA in the cohort was 2.27 cases per 100 children per month. The median survival time of the entire cohort was found to be 35.6 months (IQR: 18.6, 49.2). When time is gone the hazard of developing DKA is going to high which is well described through hazard estimate (Fig. 3).

Long rank test to compare survival curves

To test the equality of survival curves of different categorical explanatory variables, the Cochran-Mantel Haenszel Log-rank test was performed. The test statistics showed that there was a significant difference in survival function for different categorical variables. These variables include: age, family history, missed follow up, from preceding infection; tonsillitis, gastroenteritis and meningitis, from acute recent illness at time of DKA; upper respiratory tract infection, pneumonia, tonsillitis, gastroenteritis and otitis media, children with severe malnutrition, types of drug used, medication adherence and insulin placement at home.

The median survival time for those having a history of inappropriate insulin placement at home was 33.3 months with CI (25.3, 38.1) and the median survival time for those who had a history of appropriate insulin placement at home was 35.8 months with 95% CI (30.5, 42.3). The survival time difference between the groups was found statically significant with a P-value of 0.0002 (Fig. 4).

The median survival time for those who had a history of medication adherence was 44.3 months with 95% CI (36.9, 50.5) and the mean survival time for those who had a history of medication non-adherence was 27.5 months with 95% CI (23.6, 33.9). The survival time difference between the groups was found statically significant with P < 0.001 (Fig. 5).

Predictor of Diabetic ketoacidosis

The final multivariate cox proportional hazard adjusted model rivaled that, hazard of diabetic ketoacidosis decreased by 13.4% as age increased by one year (95% CI (2.34, 5.709). The hazard of Diabetic ketoacidosis was 3.52 times in children age < 5 years than those aged > 10 years (95% CI (2.25, 5.49). Also, the hazard of DKA in children who have preceding gastroenteritis were 2.18 times more than those who have no preceding gastroenteritis (95% CI (1.07, 4.45). Similarly, the hazard of DKA in children who have upper respiratory tract infection at the time of DKA development were 2.22 times more than those who have no respiratory tract infection at time of DKA development 95% CI (1.109, 4.45). The hazard of DKA in children who have a history of the inappropriate placement of insulin at home were 1.36 times more than in children who had a history of appropriate placement of insulin at home 95% CI (1.008, 1.85). Lastly, the hazard of DKA in children who have a history of medication non-adherence was 1.54 times more than in children who have a history of medication adherence 95% CI (1.11, 2.14) (table:3).

Table 3

Cox regression analysis of predictors of DKA development at East and West Gojjam zone referral hospitals, North West Ethiopia, 2019.
Variable			Survival status		CHR (95% CI)	P-value	AHR (95% CI)
Variable			Event	Censor	CHR (95% CI)	P-value	AHR (95% CI)
Age	< 5		59	34	4.58 (3.07, 6.82)	< 0.001*	3.52 (2.25, 5.49)
	5–10		87	61	1.76 (1.18, 2.62)	0.065	1.47 (0.97, 2.24)
	> 10		61	52	1		1
Sex	Male		111	84			1
Sex	Female		96	63	0.83(0.6, 0.097)	0.185	0.82(0.61,1.09)
Missed follow up	Yes		88	48
Missed follow up	No		119	99	0.75(0.57, 0.99)	0.172	0.81(0.61,1.09)
insulin storage	Appropriate		105	142	1		1
insulin storage	Inappropriate		102	5	1.98(1.51, 2.62)	0.044 *	1.36 (1.008,1.85)
Adherence	Yes		61	110	1		1
Adherence	No		146	37	2.18(0.95, 2.95)	0.01*	1.54(1.11,2.14)
Recent acute illness	Pneumonia	Yes	50	3	0.62(0.42, 0 .91)	0.615	1.09 (0.75,1.59)
	Pneumonia	No	157	144	1		1
	upper respiratory tract infection	Yes	13	-	2.44(1.39, 4.31)	0.024*	2.22(1.109, 4.45)
	upper respiratory tract infection	No	194	147	1		1
	Tonsillitis	Yes	3	-	3.06(0.97, 9.64)	0.800	1.29 (0.174, 9.60)
	Tonsillitis	No	204	147	1
	Gastroenteritis	Yes	20	2	1.69(1.06, 2.68)	0.907	1.035 (0.57,1.87)
	Gastroenteritis	No	187	145	1
	urinary tract infection	Yes	43	-	1.61(1.15, 2.25)	0.923	1.73 (0.67,1.41)
	urinary tract infection	No	164	147	1		1
	otitis media	Yes	11	-	1.98(1.08, 3.65)	0.194	1.54 (0.801,2.92)
	otitis media	No	196	147	1		1
	skin fungal infection	Yes	13	-	1.67(0.95, 2.94)	0.096	1.73(0.90,3.30)
	skin fungal infection	No	194	147	1
Preceding infection	tuberculosis	Yes	3	-	2.91(0.92, 0.16)	0.071	3.7(0. 89–15.85)
	tuberculosis	No	204	147	1		1
	Tonsillitis	Yes	5	-	2.67 (1.09, 6.52)	0.498	1.82(0.32,10.39)
	Tonsillitis	No	202	147	1		1
	gastro enteritis	Yes	12	3	2.27 (1.26, 4.09)	0.032*	2.18(1.07, 4.46)
	gastro enteritis	No	195	144	1		1
	urinary tract infection	No	11	3	1.68(0.91, 3.09)	0.189	1.58(0.79, 3.15)
	urinary tract infection	Yes	196	144	1		1
	Meningitis	Yes	1	-	8.28	0.316	0.18(0.006, 5.13)
	Meningitis	No	206	147	1		1
	other infections	Yes	12	6	1.41(0.78, 2.54)	0.446	1.27(0.68, 2.08)
	other infections	No	195	141	1		1
Having sever acute malnutrition		Yes	42	13	1.41(1.004,1.98)	0.901	1.02(0.69, 1.50)
Having sever acute malnutrition		No	165	134	1		1
Keynote * variables which were significant at p-value < 0.05 and - mean 0 observation

At the end of five years follow up, about 207 (58.4%) developed DKA with the overall incidence of 2.27 cases per 100 children per month (27.24 cases per 100 child-years) observation. The incidence rate of DKA in this study is higher than studies done in the US which were 8 per 100 person-years [3], in Sweden 3.2-3.6/100 patient-years [4] , the international society of pediatric and adolescent diabetes 2014 report 1–10% per patient per year [2] and Austria 8.4 to 18.4 per 100,000 per year [19]. Regarding cumulative incidence, this finding is consistent with studies done in north-western Nigeria which was 62.2% [10] and 55.5% in Iran [20]. However, this finding is much higher than studies done in the US which was 25.5% [21], 40.3% in Italy [22], 27% in New Zealand [23], 28% in Poland [24], 40% in southern Iraq [25]. This discrepancy might be due to differences in methodology, lifestyle, culture, economical status, access to health care facilities, and level of education of the general public.

Lack of appropriate patient (and family) education concerning the home self-management [26] may have contributed to a high incidence of DKA in Ethiopia. Thus, insufficient education and resources about self-monitoring and DKA prevention can have a great impact on DKA existence in many patients and contribute to most of the increased morbidity and premature mortality [27, 28]. Furthermore, poor access to health care facilities [29] in our country leads many patients to seek alternative treatments such as consulting traditional healers, using herbal remedies [30] prayers and rituals that encountered a delay in care which further complicating the disease process [31].

Children age <5 years were more likely to develop DKA compared to age >10 years old. This is consistent with other previous studies conducted in the US [21], Italy [22], Southern Iraq [25]. This might be the age group <5-year might be more dependent on their caregiver and more venerable to medication non-adherence. Also, this age group can encounter trouble for lifestyle modifications which are the backbone for preventing the occurrence of DKA such as adhere to a diet, exercise, and self-monitoring of blood glucose level. Also, in our study, children who have medication non-adherence were more likely to develop DKA as compared to children who adhere to medication. This finding is supported by other previous studies conducted in sub-Saharan Africa [32], north India [33], Saudi Arabia [34], New Zealand [23], Southern Iraq [25]. This might be since DM is a chronic illness after taking medication symptoms may disappear for some time so; the children may not take their medication on time.

In this children having a history of inappropriate insulin storage at home were more likely to develop DKA. This might be most of the participants were from rural areas and may not have appropriate storage materials like refrigerators. Besides due to our poor diabetic education services [26] they may have inadequate knowledge about insulin storage during temperature variation and duration of storage. Lastly in this study, children who have preceding gastroenteritis and upper respiratory tract infection at the time of DKA development were more likely to develop DKA as compared to those who have not. This is supported by the study, in Nigeria [10], sub-Saharan Africa [32], Malaysia [35], north India [33], and Saudi Arabia [34]. This might be infection can cause high levels of counteracting hormones mainly cortisol and adrenaline which triggering an episode of DKA. When there is gastroenteritis there will be vomiting and diarrhea-causing dehydration and electrolyte imbalance. This leads to an increase in the stress hormone.

Limitations

Since the data were collected from medical records, patients' charts lost and incomplete data were found. These may affect the outcome of the study. Also, this study did not include the recurrence of diabetic ketoacidosis (trend) and the lack of some variables like parental factors that can't be addressed through card review

In conclusion, the incidence of DKA in known diabetes children was found to be high. Children who have age <5-year, medication none adherence, inappropriate insulin placement at home, presence of upper respiratory tract infections at the time of diabetic ketoacidosis development, and presence of preceding gastroenteritis were predictors of DKA development at East and West Gojjam zone referral hospitals, Northwest Ethiopia. Therefore, Diabetic care clinics need to be strengthened as well as assessing, close monitoring and strengthened diabetic education for patients as well as for caregiver/families/ should be given to children who have age <5 years, non-adherence to medication, inappropriate insulin placement at home, and upper respiratory tract infection and gastroenteritis. Finally, we recommend those variables that cannot be assessed through card review and recurrence diabetic ketoacidosis will be investigated with another study design.

AHR: Adjusted hazard ratio, CHR: crude hazard ratio, DM: Diabetic mellitus, DKA: Diabetic Ketoacidosis, COPD: Chronic obstructive lung disease, HTN: hypertension, SD: Standard deviation, IQR: Interquartile range, CI: Confidence interval, US: United States, URTI: Upper respiratory tract infection, UTI: Urinary tract infection, SAM: Severe acute malnutrition.

Ethical approval and consent to participate

After the approval of the proposal, ethical clearance was obtained from the school of nursing and midwifery, college of health sciences, Addis Ababa University. Then permission letter was written to Debre Markos and Felege Hiwot referrals hospitals for data collection purposes. The confidentiality of the data had been kept. We had taken permission from hospitals medical directors and due to data had taken from chart review only, informed consent was not required

Authors’ contributions

BA and HZ performed the analysis and interpretations. BA wrote the first draft, HZ, RM & KW contributed to the design of the study and substantive revision of the final draft. All

authors read and approved the final manuscript

Funding

The work was supported by Addis Ababa University, college of health sciences. The content is solely the responsibility of the authors and does not necessarily represent the official views of the funders. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Availability of data and materials

All materials and data are available in the man author without any restriction.

Consent for publication

Not applicable

Competing interests

All authors read and approved it. No competing interests between the authors.

Acknowledgement

We would like to express our great thanks to Addis Ababa University, College of health science school of nursing and midwifery for their willingness and support. Next, our great thanks also go to Felege-Hiwot referral hospital and Debre-Markos referral hospital administrators. Lastly, we acknowledge our data collectors, supervisors and friends that support us throughout our work.

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21 Sep, 2020
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Incidence and predictors of diabetic ketoacidosis among children with diabetes in west and east gojjam zone referral hospitals north west Ethiopia, 2019.

Status:

Journal Publication

Version 2

Abstract

Figures

Background

Methods And Materials

Results

Socio-demographic characteristics

Clinical characteristics

Treatment related variables of DM diagnosed children

Incidence of diabetic ketoacidosis after DM diagnosis

Long rank test to compare survival curves

Predictor of Diabetic ketoacidosis

Discussion

Conclusions

Abbreviations

Declarations

References

Status:

Journal Publication

Version 2