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Research Article
Min Wei
Jiangsu Province and Chinese Academy of Sciences
Corresponding Author
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This work is licensed under a CC BY 4.0 License. Read Full License
Background: Acanthopanacis Cortex (AC) is a valuable Chinese herbal medicine in Eleutherococcus Maxim., which has the effects of immune inflammatory modulation, anti-stress, anti-fatigue, sedation and analgesia. The functions of herbs from Eleutherococcus Maxim. involve neuroactivity, anti-fatigue, anti-stress and immune inflammatory modulation, and the peripheral functions of which are consistent with AC. However, the central nervous system function of AC has not been clearly illustrated. Since immune inflammatory modulation plays a critical role in the treatment of depression. In this study, we investigated the effect of AC against depression through immune inflammatory modulation.
Methods: Chronic mild stress (CMS)-induced depressive mice were used to evaluate the effect of AC against depression. Behavior study and detection of neurotransmitters, neurotrophic factors and pro-inflammatory cytokines were carried out in the study. Interleukin-17 (IL-17) signaling cascade was involved to further study the underlying mechanism of AC against depression.
Results: AC had a beneficial effect on CMS-induced depressive mice, including improvement in depressive behavior and modulation of the levels of neurotransmitters, neurotrophic factors and pro-inflammatory cytokines. Moreover, AC was able to suppress IL-17-midiated signaling cascade and thereby alleviating neuroinflammation and depression.
Conclusions: Our results revealed that AC showed great effects on anti-depression through immune inflammatory modulation. These findings provide an insight into anti-depression therapy, which will be useful for the development of clinical application of AC.
Keywords
Acanthopanacis Cortex, anti-depression, immune inflammatory modulation, IL-17 signaling
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No competing interests reported.
This is a list of supplementary files associated with this preprint. Click to download.
- Table1.pdf
Table 1 25 identified compounds in AC
- Additionalfile1.docx
Additional file 1. 1589 targets related to depression.
- Additionalfile2.docx
Additional file 2. 91 chemical compounds in AC.
- Additionalfile3.docx
Additional file 3. 340 targets of identified compounds in AC.
- Additonalfile4.docx
Additional file 4. 120 potential targets in AC.
- Additonalfile5.docx
Additional file 5. IL-17 signaling pathway in KEGG pathway analysis.
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A new preprint design is coming!
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research Article
Min Wei
Jiangsu Province and Chinese Academy of Sciences
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 19 May, 2021
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Integrative & Complementary Medicine
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Acanthopanacis Cortex (AC) is a valuable Chinese herbal medicine in Eleutherococcus Maxim., which has the effects of immune inflammatory modulation, anti-stress, anti-fatigue, sedation and analgesia. The functions of herbs from Eleutherococcus Maxim. involve neuroactivity, anti-fatigue, anti-stress and immune inflammatory modulation, and the peripheral functions of which are consistent with AC. However, the central nervous system function of AC has not been clearly illustrated. Since immune inflammatory modulation plays a critical role in the treatment of depression. In this study, we investigated the effect of AC against depression through immune inflammatory modulation.
Methods: Chronic mild stress (CMS)-induced depressive mice were used to evaluate the effect of AC against depression. Behavior study and detection of neurotransmitters, neurotrophic factors and pro-inflammatory cytokines were carried out in the study. Interleukin-17 (IL-17) signaling cascade was involved to further study the underlying mechanism of AC against depression.
Results: AC had a beneficial effect on CMS-induced depressive mice, including improvement in depressive behavior and modulation of the levels of neurotransmitters, neurotrophic factors and pro-inflammatory cytokines. Moreover, AC was able to suppress IL-17-midiated signaling cascade and thereby alleviating neuroinflammation and depression.
Conclusions: Our results revealed that AC showed great effects on anti-depression through immune inflammatory modulation. These findings provide an insight into anti-depression therapy, which will be useful for the development of clinical application of AC.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
No competing interests reported.
This is a list of supplementary files associated with this preprint. Click to download.
- Table1.pdf
Table 1 25 identified compounds in AC
- Additionalfile1.docx
Additional file 1. 1589 targets related to depression.
- Additionalfile2.docx
Additional file 2. 91 chemical compounds in AC.
- Additionalfile3.docx
Additional file 3. 340 targets of identified compounds in AC.
- Additonalfile4.docx
Additional file 4. 120 potential targets in AC.
- Additonalfile5.docx
Additional file 5. IL-17 signaling pathway in KEGG pathway analysis.
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